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Podocyte infolding

MedGen UID:
1784713
•Concept ID:
C5539633
•
Finding
HPO: HP:0033483

Definition

Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM. [from HPO]

Recent clinical studies

Etiology

Subepithelial deposits with microspherular structures in membranous glomerulonephritis.
Choung HYG, Jean-Gilles J, Goldman B
Ultrastruct Pathol 2022 Jul 4;46(4):377-387. Epub 2022 Jun 16 doi: 10.1080/01913123.2022.2090646. PMID: 35709324

Diagnosis

Systemic lupus erythematosus with podocyte infolding glomerulopathy: A case report and literature review.
Zhang H, Lin J, Lu H, Zhong Y, Deng L, Kuang B, Li Q
Medicine (Baltimore) 2024 Oct 25;103(43):e39809. doi: 10.1097/MD.0000000000039809. PMID: 39470480Free PMC Article
Subepithelial deposits with microspherular structures in membranous glomerulonephritis.
Choung HYG, Jean-Gilles J, Goldman B
Ultrastruct Pathol 2022 Jul 4;46(4):377-387. Epub 2022 Jun 16 doi: 10.1080/01913123.2022.2090646. PMID: 35709324
Podocytic infolding in Schimke immuno-osseous dysplasia with novel SMARCAL1 mutations: a case report.
Xiong S, Shuai L, Li X, Dang X, Wu X, He Q
BMC Nephrol 2020 May 11;21(1):170. doi: 10.1186/s12882-020-01809-6. PMID: 32393263Free PMC Article
Podocyte infolding glomerulopathy; report of the first case in Latin America and review of the literature.
Malvar A, Davila P, Ferrari M, Delgado P, Iscoff P, Lococo B, Alberton V
Nefrologia (Engl Ed) 2020 Jul-Aug;40(4):469-473. Epub 2020 Jan 14 doi: 10.1016/j.nefro.2019.09.010. PMID: 31952852
Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.
Wöstmann F, Müller RU, Göbel H, Benzing T, Becker JU, Bartram MP
BMC Nephrol 2019 Aug 22;20(1):326. doi: 10.1186/s12882-019-1478-8. PMID: 31438874Free PMC Article

Therapy

Systemic lupus erythematosus with podocyte infolding glomerulopathy: A case report and literature review.
Zhang H, Lin J, Lu H, Zhong Y, Deng L, Kuang B, Li Q
Medicine (Baltimore) 2024 Oct 25;103(43):e39809. doi: 10.1097/MD.0000000000039809. PMID: 39470480Free PMC Article

Prognosis

Podocyte infolding glomerulopathy; report of the first case in Latin America and review of the literature.
Malvar A, Davila P, Ferrari M, Delgado P, Iscoff P, Lococo B, Alberton V
Nefrologia (Engl Ed) 2020 Jul-Aug;40(4):469-473. Epub 2020 Jan 14 doi: 10.1016/j.nefro.2019.09.010. PMID: 31952852
Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.
Wöstmann F, Müller RU, Göbel H, Benzing T, Becker JU, Bartram MP
BMC Nephrol 2019 Aug 22;20(1):326. doi: 10.1186/s12882-019-1478-8. PMID: 31438874Free PMC Article

Clinical prediction guides

Podocyte infolding glomerulopathy; report of the first case in Latin America and review of the literature.
Malvar A, Davila P, Ferrari M, Delgado P, Iscoff P, Lococo B, Alberton V
Nefrologia (Engl Ed) 2020 Jul-Aug;40(4):469-473. Epub 2020 Jan 14 doi: 10.1016/j.nefro.2019.09.010. PMID: 31952852
Podocyte Infolding Glomerulopathy (PIG) in a Patient With Undifferentiated Connective Tissue Disease: A Case Report.
Matthai SM, Mohapatra A, Mathew AJ, Roy S, Varughese S, Danda D, Tamilarasi V
Am J Kidney Dis 2018 Jul;72(1):149-153. Epub 2018 Feb 1 doi: 10.1053/j.ajkd.2017.11.023. PMID: 29395482
Invagination and infolding of podocytes in glomerular basement membrane in the cases of primary membranous nephropathy.
Masuda Y, Mii A, Shimizu A, Fujita E, Aki K, Ishikawa K, Ishizaki M, Sato S, Hayama N, Iino Y, Katayama Y, Fukuda Y
Clin Exp Nephrol 2008 Dec;12(6):440-9. Epub 2008 Nov 8 doi: 10.1007/s10157-008-0100-3. PMID: 18998049

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