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Glycogen-rich clear cell breast carcinoma

MedGen UID:
1785052
•Concept ID:
C2012261
•
Neoplastic Process
Synonyms: Breast Glycogen-Rich Carcinoma; Breast Glycogen-Rich, Clear Cell Carcinoma; glycogen-rich clear cell breast carcinoma; Glycogen-Rich, Clear Cell Breast Carcinoma; glycogen-rich, clear cell breast carcinoma
 
Monarch Initiative: MONDO:0003390

Definition

An uncommon, usually aggressive adenocarcinoma of the breast characterized by the presence of clear cells that contain glycogen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlycogen-rich clear cell breast carcinoma

Recent clinical studies

Etiology

Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
Kuo KL, Lo CS, Lee LY, Yang CH, Kuo TT
J Am Acad Dermatol 2019 Mar;80(3):749-755. Epub 2018 Dec 14 doi: 10.1016/j.jaad.2016.07.032. PMID: 30558902
Clinicopathologic characteristics and prognosis of glycogen-rich clear cell carcinoma of the breast.
Ma X, Han Y, Fan Y, Cao X, Wang X
Breast J 2014 Mar-Apr;20(2):166-73. Epub 2014 Jan 9 doi: 10.1111/tbj.12231. PMID: 24400866
Fine needle aspiration cytology of glycogen-rich clear cell carcinoma of the breast: review of 37 cases with histologic correlation.
Akbulut M, Zekioglu O, Kapkac M, Erhan Y, Ozdemir N
Acta Cytol 2008 Jan-Feb;52(1):65-71. doi: 10.1159/000325436. PMID: 18323277
Clear cell 'sugar' tumor of the breast: another extrapulmonary site and review of the literature.
Govender D, Sabaratnam RM, Essa AS
Am J Surg Pathol 2002 May;26(5):670-5. doi: 10.1097/00000478-200205000-00014. PMID: 11979098
Glycogen-rich clear cell carcinomas of the breast. A clinicopathologic and ultrastructural study.
Hull MT, Warfel KA
Am J Surg Pathol 1986 Aug;10(8):553-9. doi: 10.1097/00000478-198608000-00005. PMID: 3017138

Diagnosis

Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review.
Vranic S, Skenderi F, Beslagic V, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):655-660. doi: 10.1097/PAI.0000000000000850. PMID: 32167940
Clinicopathologic characteristics and prognosis of glycogen-rich clear cell carcinoma of the breast.
Ma X, Han Y, Fan Y, Cao X, Wang X
Breast J 2014 Mar-Apr;20(2):166-73. Epub 2014 Jan 9 doi: 10.1111/tbj.12231. PMID: 24400866
Clinical and pathological features of glycogen-rich clear cell carcinoma of the breast.
Kuroda H, Sakamoto G, Ohnisi K, Itoyama S
Breast Cancer 2005;12(3):189-95. doi: 10.2325/jbcs.12.189. PMID: 16110288
Glycogen-rich clear cell mammary malignant myoepithelioma.
Son HJ, Jung SH, Lee SY, Moon WS
Breast 2004 Dec;13(6):506-9. doi: 10.1016/j.breast.2004.07.003. PMID: 15563859
Glycogen-rich clear-cell carcinoma of the breast: a clinicopathologic and flow cytometric study.
Toikkanen S, Joensuu H
Hum Pathol 1991 Jan;22(1):81-3. doi: 10.1016/0046-8177(91)90066-x. PMID: 1985082

Therapy

Glycogen-rich carcinomas of the breast display unique characteristics with respect to proliferation and the frequency of oligonucleosomal fragments.
Varga Z, Caduff R
Breast Cancer Res Treat 1999 Sep;57(2):215-9. doi: 10.1023/a:1006285819701. PMID: 10598049
Clear cell myoepithelial neoplasm of the breast.
Cartagena N Jr, Cabello-Inchausti B, Willis I, Poppiti R Jr
Hum Pathol 1988 Oct;19(10):1239-43. doi: 10.1016/s0046-8177(88)80159-x. PMID: 2844648

Prognosis

Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review.
Vranic S, Skenderi F, Beslagic V, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):655-660. doi: 10.1097/PAI.0000000000000850. PMID: 32167940
Invasive Mammary Carcinoma With Mixed Invasive Papillary and Glycogen Rich Clear Cell Features.
Solanki MH, Derylo AF, Jorns JM
Int J Surg Pathol 2018 Sep;26(6):569-572. Epub 2018 Mar 27 doi: 10.1177/1066896918765651. PMID: 29580112
Clinicopathologic characteristics and prognosis of glycogen-rich clear cell carcinoma of the breast.
Ma X, Han Y, Fan Y, Cao X, Wang X
Breast J 2014 Mar-Apr;20(2):166-73. Epub 2014 Jan 9 doi: 10.1111/tbj.12231. PMID: 24400866
Immunophenotypes of glycogen rich clear cell carcinoma.
Kim SE, Koo JS, Jung WH
Yonsei Med J 2012 Nov 1;53(6):1142-6. doi: 10.3349/ymj.2012.53.6.1142. PMID: 23074114Free PMC Article
Clinical and pathological features of glycogen-rich clear cell carcinoma of the breast.
Kuroda H, Sakamoto G, Ohnisi K, Itoyama S
Breast Cancer 2005;12(3):189-95. doi: 10.2325/jbcs.12.189. PMID: 16110288

Clinical prediction guides

Clinicopathological characteristics of breast sebaceous adenocarcinoma.
Heng C, Wei T, Yingbing T, Hanzhong L
Pol J Pathol 2018;69(3):226-233. doi: 10.5114/pjp.2018.79542. PMID: 30509049
Clinicopathologic characteristics and prognosis of glycogen-rich clear cell carcinoma of the breast.
Ma X, Han Y, Fan Y, Cao X, Wang X
Breast J 2014 Mar-Apr;20(2):166-73. Epub 2014 Jan 9 doi: 10.1111/tbj.12231. PMID: 24400866
Histopathological and immunohistochemical findings in a case of glycogen-rich clear cell carcinoma of the breast.
Takekawa Y, Kubo A, Morita T, Kameda K, Kimura M, Sakakibara M, Yoshii R, Yamashita Y
Rinsho Byori 2006 Jan;54(1):27-30. PMID: 16499226
Cytology of glycogen-rich (clear cell) carcinoma of the breast. A report of two cases.
Kern SB, Andera L
Acta Cytol 1997 Mar-Apr;41(2):556-60. doi: 10.1159/000332556. PMID: 9100798
Intralobular growth of myoepithelial cell carcinoma of the breast.
Soares J, Tomasic G, Bucciarelli E, Eusebi V
Virchows Arch 1994;425(2):205-10. doi: 10.1007/BF00230358. PMID: 7952505

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