U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mesonephric-Like Adenocarcinoma

MedGen UID:
1785088
•Concept ID:
C5548439
•
Neoplastic Process
Synonym: Mesonephric-like adenocarcinoma
SNOMED CT: Mesonephric-like adenocarcinoma (1157183001)

Definition

An exceedingly rare adenocarcinoma that arises from the uterine corpus and ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesonephric-Like Adenocarcinoma

Professional guidelines

PubMed

Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.
Brambs CE, Horn LC, Hiller R, Krücken I, Braun C, Christmann C, Monecke A, Höhn AK
J Cancer Res Clin Oncol 2023 Nov;149(17):15727-15736. Epub 2023 Sep 5 doi: 10.1007/s00432-023-05306-9. PMID: 37668797Free PMC Article

Recent clinical studies

Etiology

Mesonephric-like adenocarcinoma harbours characteristic copy number variations and a distinct DNA methylation signature closely related to mesonephric adenocarcinoma of the cervix.
Kommoss FK, Lee CH, Tessier-Cloutier B, Gilks CB, Stewart CJ, von Deimling A, Köbel M
J Pathol 2024 Jan;262(1):4-9. Epub 2023 Oct 18 doi: 10.1002/path.6217. PMID: 37850576
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma Cases.
Kim HG, Kim H, Yeo MK, Won KY, Kim YS, Han GH, Kim HS, Na K
Cancer Genomics Proteomics 2022 Jul-Aug;19(4):526-539. doi: 10.21873/cgp.20338. PMID: 35732320Free PMC Article
Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors.
Buza N
Semin Diagn Pathol 2022 Jan;39(1):58-77. Epub 2021 Nov 3 doi: 10.1053/j.semdp.2021.10.006. PMID: 34750021
Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma.
Choi KH, Kim H, Bae GE, Lee SH, Woo HY, Kim HS
Anticancer Res 2021 Sep;41(9):4587-4601. doi: 10.21873/anticanres.15272. PMID: 34475087
Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract: A Multi-institutional Study.
Pors J, Segura S, Chiu DS, Almadani N, Ren H, Fix DJ, Howitt BE, Kolin D, McCluggage WG, Mirkovic J, Gilks B, Park KJ, Hoang L
Am J Surg Pathol 2021 Apr 1;45(4):498-506. doi: 10.1097/PAS.0000000000001612. PMID: 33165093Free PMC Article

Diagnosis

Mesonephric-like adenocarcinoma of the ovary.
Yang Y, Zhao M, Jia Q, Tang H, Xing T, Li Y, Tang B, Xu L, Wei W, Zheng H, Shi R, Xia B, Chen J
J Ovarian Res 2024 Mar 5;17(1):57. doi: 10.1186/s13048-024-01383-7. PMID: 38444000Free PMC Article
Cytological features of mesonephric-like adenocarcinoma of the uterine corpus.
Seo Y, Park E, Kim HS
Diagn Cytopathol 2023 May;51(5):294-306. Epub 2023 Feb 8 doi: 10.1002/dc.25111. PMID: 36756667
Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors.
Buza N
Semin Diagn Pathol 2022 Jan;39(1):58-77. Epub 2021 Nov 3 doi: 10.1053/j.semdp.2021.10.006. PMID: 34750021
Mesonephric-like adenocarcinoma of the ovary: A case report and a review of the literature.
Chen Q, Shen Y, Xie C
Medicine (Baltimore) 2020 Nov 25;99(48):e23450. doi: 10.1097/MD.0000000000023450. PMID: 33235131Free PMC Article
Mesonephric proliferations of the female genital tract.
Howitt BE, Nucci MR
Pathology 2018 Feb;50(2):141-150. Epub 2017 Dec 19 doi: 10.1016/j.pathol.2017.11.084. PMID: 29269124

Therapy

Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Prognosis

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Clinicopathological and Prognostic Significance of L1 Cell Adhesion Molecule (L1CAM) Over-expression.
Park S, Cho Y, Kim HS
Anticancer Res 2023 Oct;43(10):4559-4571. doi: 10.21873/anticanres.16650. PMID: 37772557
Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.
Brambs CE, Horn LC, Hiller R, Krücken I, Braun C, Christmann C, Monecke A, Höhn AK
J Cancer Res Clin Oncol 2023 Nov;149(17):15727-15736. Epub 2023 Sep 5 doi: 10.1007/s00432-023-05306-9. PMID: 37668797Free PMC Article
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma Cases.
Kim HG, Kim H, Yeo MK, Won KY, Kim YS, Han GH, Kim HS, Na K
Cancer Genomics Proteomics 2022 Jul-Aug;19(4):526-539. doi: 10.21873/cgp.20338. PMID: 35732320Free PMC Article
Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors.
Buza N
Semin Diagn Pathol 2022 Jan;39(1):58-77. Epub 2021 Nov 3 doi: 10.1053/j.semdp.2021.10.006. PMID: 34750021
Mesonephric-like adenocarcinoma of the ovary: A case report and a review of the literature.
Chen Q, Shen Y, Xie C
Medicine (Baltimore) 2020 Nov 25;99(48):e23450. doi: 10.1097/MD.0000000000023450. PMID: 33235131Free PMC Article

Clinical prediction guides

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comparison Between Mismatch Repair Protein Immunostaining and Microsatellite Instability Testing.
Kim H, Kim HS
Anticancer Res 2023 Apr;43(4):1785-1795. doi: 10.21873/anticanres.16332. PMID: 36974792
Mesonephric-like adenocarcinoma of the female genital tract: novel observations and detailed molecular characterisation of mixed tumours and mesonephric-like carcinosarcomas.
Mirkovic J, Olkhov-Mitsel E, Amemiya Y, Al-Hussaini M, Nofech-Mozes S, Djordjevic B, Kupets R, Seth A, McCluggage WG
Histopathology 2023 Jun;82(7):978-990. Epub 2023 Mar 31 doi: 10.1111/his.14892. PMID: 36860193
Cytological features of mesonephric-like adenocarcinoma of the uterine corpus.
Seo Y, Park E, Kim HS
Diagn Cytopathol 2023 May;51(5):294-306. Epub 2023 Feb 8 doi: 10.1002/dc.25111. PMID: 36756667
Mesonephric-like Adenocarcinoma of the Female Genital Tract: From Morphologic Observations to a Well-characterized Carcinoma With Aggressive Clinical Behavior.
McCluggage WG
Adv Anat Pathol 2022 Jul 1;29(4):208-216. Epub 2022 Apr 7 doi: 10.1097/PAP.0000000000000342. PMID: 35384888
Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors.
Buza N
Semin Diagn Pathol 2022 Jan;39(1):58-77. Epub 2021 Nov 3 doi: 10.1053/j.semdp.2021.10.006. PMID: 34750021

Recent systematic reviews

Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...