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Perifissural pulmonary nodule

MedGen UID:
1785333
•Concept ID:
C5539720
•
Finding
HPO: HP:0033613

Definition

Solid, homogenous nodules characterized by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes. [from HPO]

Professional guidelines

PubMed

ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.
Christensen J, Prosper AE, Wu CC, Chung J, Lee E, Elicker B, Hunsaker AR, Petranovic M, Sandler KL, Stiles B, Mazzone P, Yankelevitz D, Aberle D, Chiles C, Kazerooni E
Chest 2024 Mar;165(3):738-753. Epub 2024 Jan 30 doi: 10.1016/j.chest.2023.10.028. PMID: 38300206
ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.
Christensen J, Prosper AE, Wu CC, Chung J, Lee E, Elicker B, Hunsaker AR, Petranovic M, Sandler KL, Stiles B, Mazzone P, Yankelevitz D, Aberle D, Chiles C, Kazerooni E
J Am Coll Radiol 2024 Mar;21(3):473-488. Epub 2023 Oct 10 doi: 10.1016/j.jacr.2023.09.009. PMID: 37820837

Recent clinical studies

Etiology

Strategies for Reducing False-Positive Screening Results for Intermediate-Size Nodules Evaluated Using Lung-RADS: A Secondary Analysis of National Lung Screening Trial Data.
Hammer MM, Hunsaker AR
AJR Am J Roentgenol 2022 Sep;219(3):397-405. Epub 2022 Mar 23 doi: 10.2214/AJR.22.27595. PMID: 35319912Free PMC Article
Evaluation of a novel deep learning-based classifier for perifissural nodules.
Han D, Heuvelmans M, Rook M, Dorrius M, van Houten L, Price NW, Pickup LC, Novotny P, Oudkerk M, Declerck J, Gleeson F, van Ooijen P, Vliegenthart R
Eur Radiol 2021 Jun;31(6):4023-4030. Epub 2020 Dec 2 doi: 10.1007/s00330-020-07509-x. PMID: 33269413Free PMC Article
Classification of CT Pulmonary Opacities as Perifissural Nodules: Reader Variability.
Schreuder A, van Ginneken B, Scholten ET, Jacobs C, Prokop M, Sverzellati N, Desai SR, Devaraj A, Schaefer-Prokop CM
Radiology 2018 Sep;288(3):867-875. Epub 2018 Jul 3 doi: 10.1148/radiol.2018172771. PMID: 29969076
Incidental perifissural nodules on routine chest computed tomography: lung cancer or not?
Mets OM, Chung K, Scholten ET, Veldhuis WB, Prokop M, van Ginneken B, Schaefer-Prokop CM, de Jong PA
Eur Radiol 2018 Mar;28(3):1095-1101. Epub 2017 Oct 6 doi: 10.1007/s00330-017-5055-x. PMID: 28986629Free PMC Article
The Lung Reporting and Data System (LU-RADS): a proposal for computed tomography screening.
Manos D, Seely JM, Taylor J, Borgaonkar J, Roberts HC, Mayo JR
Can Assoc Radiol J 2014 May;65(2):121-34. doi: 10.1016/j.carj.2014.03.004. PMID: 24758919

Diagnosis

Strategies for Reducing False-Positive Screening Results for Intermediate-Size Nodules Evaluated Using Lung-RADS: A Secondary Analysis of National Lung Screening Trial Data.
Hammer MM, Hunsaker AR
AJR Am J Roentgenol 2022 Sep;219(3):397-405. Epub 2022 Mar 23 doi: 10.2214/AJR.22.27595. PMID: 35319912Free PMC Article
Evaluation of a novel deep learning-based classifier for perifissural nodules.
Han D, Heuvelmans M, Rook M, Dorrius M, van Houten L, Price NW, Pickup LC, Novotny P, Oudkerk M, Declerck J, Gleeson F, van Ooijen P, Vliegenthart R
Eur Radiol 2021 Jun;31(6):4023-4030. Epub 2020 Dec 2 doi: 10.1007/s00330-020-07509-x. PMID: 33269413Free PMC Article
Classification of CT Pulmonary Opacities as Perifissural Nodules: Reader Variability.
Schreuder A, van Ginneken B, Scholten ET, Jacobs C, Prokop M, Sverzellati N, Desai SR, Devaraj A, Schaefer-Prokop CM
Radiology 2018 Sep;288(3):867-875. Epub 2018 Jul 3 doi: 10.1148/radiol.2018172771. PMID: 29969076
Incidental perifissural nodules on routine chest computed tomography: lung cancer or not?
Mets OM, Chung K, Scholten ET, Veldhuis WB, Prokop M, van Ginneken B, Schaefer-Prokop CM, de Jong PA
Eur Radiol 2018 Mar;28(3):1095-1101. Epub 2017 Oct 6 doi: 10.1007/s00330-017-5055-x. PMID: 28986629Free PMC Article
Initial LDCT appearance of incident lung cancers in the ITALUNG trial.
Mascalchi M, Picozzi G, Falchini M, Vella A, Diciotti S, Carrozzi L, Pegna AL, Falaschi F
Eur J Radiol 2014 Nov;83(11):2080-6. Epub 2014 Aug 12 doi: 10.1016/j.ejrad.2014.07.019. PMID: 25174775

Therapy

Strategies for Reducing False-Positive Screening Results for Intermediate-Size Nodules Evaluated Using Lung-RADS: A Secondary Analysis of National Lung Screening Trial Data.
Hammer MM, Hunsaker AR
AJR Am J Roentgenol 2022 Sep;219(3):397-405. Epub 2022 Mar 23 doi: 10.2214/AJR.22.27595. PMID: 35319912Free PMC Article
New Fissure-Attached Nodules in Lung Cancer Screening: A Brief Report From The NELSON Study.
Han D, Heuvelmans MA, van der Aalst CM, van Smoorenburg LH, Dorrius MD, Rook M, Nackaerts K, Walter JE, Groen HJM, Vliegenthart R, de Koning HJ, Oudkerk M
J Thorac Oncol 2020 Jan;15(1):125-129. Epub 2019 Oct 10 doi: 10.1016/j.jtho.2019.09.193. PMID: 31606605
Initial LDCT appearance of incident lung cancers in the ITALUNG trial.
Mascalchi M, Picozzi G, Falchini M, Vella A, Diciotti S, Carrozzi L, Pegna AL, Falaschi F
Eur J Radiol 2014 Nov;83(11):2080-6. Epub 2014 Aug 12 doi: 10.1016/j.ejrad.2014.07.019. PMID: 25174775
The Lung Reporting and Data System (LU-RADS): a proposal for computed tomography screening.
Manos D, Seely JM, Taylor J, Borgaonkar J, Roberts HC, Mayo JR
Can Assoc Radiol J 2014 May;65(2):121-34. doi: 10.1016/j.carj.2014.03.004. PMID: 24758919
Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of malignancy.
de Hoop B, van Ginneken B, Gietema H, Prokop M
Radiology 2012 Nov;265(2):611-6. Epub 2012 Aug 28 doi: 10.1148/radiol.12112351. PMID: 22929331

Prognosis

Clinical significance of perifissural nodules in the oncologic population.
Golia Pernicka JS, Hayes SA, Schor-Bardach R, Sharma R, Zheng J, Moskowitz C, Ginsberg MS
Clin Imaging 2019 Sep-Oct;57:110-114. Epub 2019 May 31 doi: 10.1016/j.clinimag.2019.05.017. PMID: 31207563Free PMC Article
Dendriform Pulmonary Ossification in the Absence of Usual Interstitial Pneumonia: CT Features and Possible Association With Recurrent Acid Aspiration.
Gruden JF, Green DB, Legasto AC, Jensen EA, Panse PM
AJR Am J Roentgenol 2017 Dec;209(6):1209-1215. Epub 2017 Oct 5 doi: 10.2214/AJR.17.18063. PMID: 28981359
Initial LDCT appearance of incident lung cancers in the ITALUNG trial.
Mascalchi M, Picozzi G, Falchini M, Vella A, Diciotti S, Carrozzi L, Pegna AL, Falaschi F
Eur J Radiol 2014 Nov;83(11):2080-6. Epub 2014 Aug 12 doi: 10.1016/j.ejrad.2014.07.019. PMID: 25174775
Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of malignancy.
de Hoop B, van Ginneken B, Gietema H, Prokop M
Radiology 2012 Nov;265(2):611-6. Epub 2012 Aug 28 doi: 10.1148/radiol.12112351. PMID: 22929331
Perifissural nodules seen at CT screening for lung cancer.
Ahn MI, Gleeson TG, Chan IH, McWilliams AM, Macdonald SL, Lam S, Atkar-Khattra S, Mayo JR
Radiology 2010 Mar;254(3):949-56. doi: 10.1148/radiol.09090031. PMID: 20177105

Clinical prediction guides

Clinical significance of perifissural nodules in the oncologic population.
Golia Pernicka JS, Hayes SA, Schor-Bardach R, Sharma R, Zheng J, Moskowitz C, Ginsberg MS
Clin Imaging 2019 Sep-Oct;57:110-114. Epub 2019 May 31 doi: 10.1016/j.clinimag.2019.05.017. PMID: 31207563Free PMC Article
Classification of CT Pulmonary Opacities as Perifissural Nodules: Reader Variability.
Schreuder A, van Ginneken B, Scholten ET, Jacobs C, Prokop M, Sverzellati N, Desai SR, Devaraj A, Schaefer-Prokop CM
Radiology 2018 Sep;288(3):867-875. Epub 2018 Jul 3 doi: 10.1148/radiol.2018172771. PMID: 29969076
Frequency and characteristics of pulmonary nodules in children at computed tomography.
Samim A, Littooij AS, van den Heuvel-Eibrink MM, Wessels FJ, Nievelstein RAJ, de Jong PA
Pediatr Radiol 2017 Dec;47(13):1751-1758. Epub 2017 Sep 4 doi: 10.1007/s00247-017-3946-2. PMID: 28871322Free PMC Article
Initial LDCT appearance of incident lung cancers in the ITALUNG trial.
Mascalchi M, Picozzi G, Falchini M, Vella A, Diciotti S, Carrozzi L, Pegna AL, Falaschi F
Eur J Radiol 2014 Nov;83(11):2080-6. Epub 2014 Aug 12 doi: 10.1016/j.ejrad.2014.07.019. PMID: 25174775
Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of malignancy.
de Hoop B, van Ginneken B, Gietema H, Prokop M
Radiology 2012 Nov;265(2):611-6. Epub 2012 Aug 28 doi: 10.1148/radiol.12112351. PMID: 22929331

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