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Circulating nucleated red blood cells

MedGen UID:
1785393
•Concept ID:
C5539477
•
Finding
HPO: HP:0033281

Definition

The presence of nucleated red blood cells in the peripheral blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCirculating nucleated red blood cells

Conditions with this feature

Congenital dyserythropoietic anemia type 4
MedGen UID:
462276
•Concept ID:
C3150926
•
Disease or Syndrome
Congenital dyserythropoietic anemia type IV (CDAN4) is an autosomal dominant red blood cell disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDAN4 also have increased levels of fetal hemoglobin (summary by Arnaud et al., 2010). For a discussion of genetic heterogeneity of congenital dyserythropoietic anemia, see CDAN1 (224120).
See: Condition Record
Congenital dyserythropoietic anemia type 4

Professional guidelines

PubMed

Frequency-enhanced transferrin receptor antibody-labelled microfluidic chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis.
Zhang H, Yang Y, Li X, Shi Y, Hu B, An Y, Zhu Z, Hong G, Yang CJ
Lab Chip 2018 Sep 11;18(18):2749-2756. doi: 10.1039/c8lc00650d. PMID: 30123896

Recent clinical studies

Etiology

Nucleated red blood cells as a biomarker for mortality in infants and neonates requiring veno-arterial extracorporeal membrane oxygenation for cardiac disease.
Piggott KD, Norlin C, Laviolette C, Turner J, Lewis L, Soliman A, Hebert D, Pettitt T
Perfusion 2023 Mar;38(2):299-304. Epub 2021 Oct 12 doi: 10.1177/02676591211050607. PMID: 34636269
Iron deficiency as promoter of heavy metals-induced acute myeloid leukemia.
Cirovic A, Cirovic A
Leuk Res 2022 Jan;112:106755. Epub 2021 Nov 22 doi: 10.1016/j.leukres.2021.106755. PMID: 34844140
Peripheral Nucleated Red Blood Cells and Mortality in Critically Ill Children.
Pedersen SJV, Chok R, McKillop S, Rojas-Vasquez M, Duff JP, Szkotak A, Bruce AA
J Pediatr Hematol Oncol 2022 Apr 1;44(3):79-83. doi: 10.1097/MPH.0000000000002294. PMID: 34486569
Nucleated red blood cells as a biomarker for mortality in neonates following cardiac surgery.
Piggott KD, Maqsood S, Warner CL, Pettitt T, Yang S, Turner J, Soliman A, Norlin C, Lewis L, Bhatia A
Cardiol Young 2022 Jul;32(7):1048-1052. Epub 2021 Aug 31 doi: 10.1017/S1047951121003577. PMID: 34462029
Reticulocytes in sports medicine: an update.
Lombardi G, Colombini A, Lanteri P, Banfi G
Adv Clin Chem 2013;59:125-53. doi: 10.1016/b978-0-12-405211-6.00005-x. PMID: 23461135

Diagnosis

Diagnostic Value and Prognostic Significance of Nucleated Red Blood Cells (NRBCs) in Selected Medical Conditions.
Pikora K, Krętowska-Grunwald A, Krawczuk-Rybak M, Sawicka-Żukowska M
Cells 2023 Jul 9;12(14) doi: 10.3390/cells12141817. PMID: 37508482Free PMC Article
Aptamer-Mediated Enrichment of Rare Circulating Fetal Nucleated Red Blood Cells for Noninvasive Prenatal Diagnosis.
Li X, Wang T, Xie T, Dai J, Zhang Y, Ling N, Guo J, Li C, Sun X, Zhang X, Peng Y, Wang H, Peng T, Ye M, Tan W
Anal Chem 2023 Mar 28;95(12):5419-5427. Epub 2023 Mar 15 doi: 10.1021/acs.analchem.3c00115. PMID: 36920371
Nucleated red blood cells as a biomarker for mortality in neonates following cardiac surgery.
Piggott KD, Maqsood S, Warner CL, Pettitt T, Yang S, Turner J, Soliman A, Norlin C, Lewis L, Bhatia A
Cardiol Young 2022 Jul;32(7):1048-1052. Epub 2021 Aug 31 doi: 10.1017/S1047951121003577. PMID: 34462029
Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases.
Poz D, De Falco E, Pisano C, Madonna R, Ferdinandy P, Balistreri CR
Rejuvenation Res 2019 Apr;22(2):146-162. Epub 2018 Oct 13 doi: 10.1089/rej.2018.2094. PMID: 30132390
Using fetal cells for prenatal diagnosis: History and recent progress.
Beaudet AL
Am J Med Genet C Semin Med Genet 2016 Jun;172(2):123-7. Epub 2016 May 2 doi: 10.1002/ajmg.c.31487. PMID: 27133782

Therapy

Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article
Clinical and non-clinical safety of artemisinin derivatives in pregnancy.
Gomes C, Boareto AC, Dalsenter PR
Reprod Toxicol 2016 Oct;65:194-203. Epub 2016 Aug 6 doi: 10.1016/j.reprotox.2016.08.003. PMID: 27506918
Estimating the nucleated red blood cell 'emergence time' in neonates.
Christensen RD, Lambert DK, Richards DS
J Perinatol 2014 Feb;34(2):116-9. Epub 2013 Sep 12 doi: 10.1038/jp.2013.113. PMID: 24030675
Erythropoiesis and iron.
Cavill I
Best Pract Res Clin Haematol 2002 Jun;15(2):399-409. doi: 10.1016/s1521-6926(02)90004-6. PMID: 12401314
Nucleated red blood cells in infants of smoking mothers.
Yeruchimovich M, Dollberg S, Green DW, Mimouni FB
Obstet Gynecol 1999 Mar;93(3):403-6. doi: 10.1016/s0029-7844(98)00442-6. PMID: 10074988

Prognosis

Diagnostic Value and Prognostic Significance of Nucleated Red Blood Cells (NRBCs) in Selected Medical Conditions.
Pikora K, Krętowska-Grunwald A, Krawczuk-Rybak M, Sawicka-Żukowska M
Cells 2023 Jul 9;12(14) doi: 10.3390/cells12141817. PMID: 37508482Free PMC Article
Peripheral Nucleated Red Blood Cells and Mortality in Critically Ill Children.
Pedersen SJV, Chok R, McKillop S, Rojas-Vasquez M, Duff JP, Szkotak A, Bruce AA
J Pediatr Hematol Oncol 2022 Apr 1;44(3):79-83. doi: 10.1097/MPH.0000000000002294. PMID: 34486569
Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases.
Monteiro Júnior JGM, de Oliveira Cipriano Torres D, Filho DCS
Curr Cardiol Rev 2019;15(4):274-282. doi: 10.2174/1573403X15666190225123544. PMID: 30799790Free PMC Article
Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases.
Poz D, De Falco E, Pisano C, Madonna R, Ferdinandy P, Balistreri CR
Rejuvenation Res 2019 Apr;22(2):146-162. Epub 2018 Oct 13 doi: 10.1089/rej.2018.2094. PMID: 30132390
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression.
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang L, Wang Q, Yu Y, Li N, Cao X
Cell 2018 Apr 19;173(3):634-648.e12. Epub 2018 Mar 29 doi: 10.1016/j.cell.2018.02.061. PMID: 29606356

Clinical prediction guides

Diagnostic Value and Prognostic Significance of Nucleated Red Blood Cells (NRBCs) in Selected Medical Conditions.
Pikora K, Krętowska-Grunwald A, Krawczuk-Rybak M, Sawicka-Żukowska M
Cells 2023 Jul 9;12(14) doi: 10.3390/cells12141817. PMID: 37508482Free PMC Article
Peripheral Nucleated Red Blood Cells and Mortality in Critically Ill Children.
Pedersen SJV, Chok R, McKillop S, Rojas-Vasquez M, Duff JP, Szkotak A, Bruce AA
J Pediatr Hematol Oncol 2022 Apr 1;44(3):79-83. doi: 10.1097/MPH.0000000000002294. PMID: 34486569
Cellular Basis of Embryonic Hematopoiesis and Its Implications in Prenatal Erythropoiesis.
Yamane T
Int J Mol Sci 2020 Dec 8;21(24) doi: 10.3390/ijms21249346. PMID: 33302450Free PMC Article
Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases.
Monteiro Júnior JGM, de Oliveira Cipriano Torres D, Filho DCS
Curr Cardiol Rev 2019;15(4):274-282. doi: 10.2174/1573403X15666190225123544. PMID: 30799790Free PMC Article
Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases.
Poz D, De Falco E, Pisano C, Madonna R, Ferdinandy P, Balistreri CR
Rejuvenation Res 2019 Apr;22(2):146-162. Epub 2018 Oct 13 doi: 10.1089/rej.2018.2094. PMID: 30132390

Recent systematic reviews

Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.
Di Girolamo R, Khalil A, Alameddine S, D'Angelo E, Galliani C, Matarrelli B, Buca D, Liberati M, Rizzo G, D'Antonio F
Am J Obstet Gynecol MFM 2021 Nov;3(6):100468. Epub 2021 Aug 21 doi: 10.1016/j.ajogmf.2021.100468. PMID: 34425296Free PMC Article

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