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Decreased circulating fetuin A concentration

MedGen UID:
1785570
•Concept ID:
C5539501
•
Finding
HPO: HP:0033306

Definition

A reduction below normal of fetuin A in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating fetuin A concentration

Recent clinical studies

Etiology

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Is fetuin-A a biomarker of dialysis access dysfunction?
Roca-Tey R, Ramírez de Arellano M, González-Oliva JC, Roda A, Samon R, Ibrik O, Ugalde-Altamirano J, Viladoms J, Calls J
J Vasc Access 2023 May;24(3):458-464. Epub 2021 Jul 29 doi: 10.1177/11297298211035846. PMID: 34325543
Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes mellitus.
Šimják P, Cinkajzlová A, Anderlová K, Kloučková J, Kratochvílová H, Lacinová Z, Kaválková P, Krejčí H, Mráz M, Pařízek A, Kršek M, Haluzík M
Physiol Res 2018 Nov 28;67(Suppl 3):S531-S542. doi: 10.33549/physiolres.934017. PMID: 30484680
Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus.
Kralisch S, Hoffmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Fasshauer M, Ebert T
Metabolism 2017 Mar;68:88-94. Epub 2016 Dec 9 doi: 10.1016/j.metabol.2016.11.017. PMID: 28183456
Association between dietary factors and plasma fetuin-A concentrations in the general population.
Nimptsch K, Janke J, Pischon T, Linseisen J
Br J Nutr 2015 Oct 28;114(8):1278-85. Epub 2015 Aug 28 doi: 10.1017/S0007114515002639. PMID: 26316198

Diagnosis

Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes mellitus.
Šimják P, Cinkajzlová A, Anderlová K, Kloučková J, Kratochvílová H, Lacinová Z, Kaválková P, Krejčí H, Mráz M, Pařízek A, Kršek M, Haluzík M
Physiol Res 2018 Nov 28;67(Suppl 3):S531-S542. doi: 10.33549/physiolres.934017. PMID: 30484680
Comparative effects of metformin and pioglitazone on fetuin-A and osteoprotegerin concentrations in patients with newly diagnosed diabetes: A randomized clinical trial.
Esteghamati A, Afarideh M, Feyzi S, Noshad S, Nakhjavani M
Diabetes Metab Syndr 2015 Oct-Dec;9(4):258-65. Epub 2014 Oct 14 doi: 10.1016/j.dsx.2014.09.009. PMID: 25450818
Serum fetuin-A concentration and fetuin-A-containing calciprotein particles in patients with chronic inflammatory disease and renal failure.
Smith ER, Cai MM, McMahon LP, Pedagogos E, Toussaint ND, Brumby C, Holt SG
Nephrology (Carlton) 2013 Mar;18(3):215-21. doi: 10.1111/nep.12021. PMID: 23231493
Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome.
Kaushik SV, Plaisance EP, Kim T, Huang EY, Mahurin AJ, Grandjean PW, Mathews ST
Diabetes Metab Res Rev 2009 Jul;25(5):427-34. doi: 10.1002/dmrr.967. PMID: 19405044
Fetuin-A induces cytokine expression and suppresses adiponectin production.
Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N
PLoS One 2008 Mar 12;3(3):e1765. doi: 10.1371/journal.pone.0001765. PMID: 18335040Free PMC Article

Therapy

Is fetuin-A a biomarker of dialysis access dysfunction?
Roca-Tey R, Ramírez de Arellano M, González-Oliva JC, Roda A, Samon R, Ibrik O, Ugalde-Altamirano J, Viladoms J, Calls J
J Vasc Access 2023 May;24(3):458-464. Epub 2021 Jul 29 doi: 10.1177/11297298211035846. PMID: 34325543
Identifying early pathogenic events during vascular calcification in uremic rats.
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316
Association between dietary factors and plasma fetuin-A concentrations in the general population.
Nimptsch K, Janke J, Pischon T, Linseisen J
Br J Nutr 2015 Oct 28;114(8):1278-85. Epub 2015 Aug 28 doi: 10.1017/S0007114515002639. PMID: 26316198
Comparative effects of metformin and pioglitazone on fetuin-A and osteoprotegerin concentrations in patients with newly diagnosed diabetes: A randomized clinical trial.
Esteghamati A, Afarideh M, Feyzi S, Noshad S, Nakhjavani M
Diabetes Metab Syndr 2015 Oct-Dec;9(4):258-65. Epub 2014 Oct 14 doi: 10.1016/j.dsx.2014.09.009. PMID: 25450818
Decreased levels of circulating alpha2-Heremans-Schmid glycoprotein/Fetuin-A (AHSG) in patients with rheumatoid arthritis.
Sato H, Kazama JJ, Wada Y, Kuroda T, Narita I, Gejyo F, Gao P, Yamashita H
Intern Med 2007;46(20):1685-91. Epub 2007 Oct 15 doi: 10.2169/internalmedicine.46.6269. PMID: 17938521

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus.
Kralisch S, Hoffmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Fasshauer M, Ebert T
Metabolism 2017 Mar;68:88-94. Epub 2016 Dec 9 doi: 10.1016/j.metabol.2016.11.017. PMID: 28183456
Serum levels of fetuin A are increased in women with gestational diabetes mellitus.
Iyidir OT, Degertekin CK, Yilmaz BA, Altinova AE, Toruner FB, Bozkurt N, Ayvaz G, Akturk M
Arch Gynecol Obstet 2015 Apr;291(4):933-7. Epub 2014 Sep 27 doi: 10.1007/s00404-014-3490-3. PMID: 25260988
Serum fetuin-A concentration and fetuin-A-containing calciprotein particles in patients with chronic inflammatory disease and renal failure.
Smith ER, Cai MM, McMahon LP, Pedagogos E, Toussaint ND, Brumby C, Holt SG
Nephrology (Carlton) 2013 Mar;18(3):215-21. doi: 10.1111/nep.12021. PMID: 23231493
Circulating fetuin-A predicts early mortality in chronic hemodialysis patients.
Bláha V, Mistrík E, Dusilová-Sulková S, Kalousová M, Andrýs C, Bláha M, Sobotka L
Clin Biochem 2009 Jul;42(10-11):996-1000. Epub 2009 Mar 31 doi: 10.1016/j.clinbiochem.2009.03.021. PMID: 19341719

Clinical prediction guides

Identifying early pathogenic events during vascular calcification in uremic rats.
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316
Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus.
Kralisch S, Hoffmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Fasshauer M, Ebert T
Metabolism 2017 Mar;68:88-94. Epub 2016 Dec 9 doi: 10.1016/j.metabol.2016.11.017. PMID: 28183456
Serum levels of fetuin A are increased in women with gestational diabetes mellitus.
Iyidir OT, Degertekin CK, Yilmaz BA, Altinova AE, Toruner FB, Bozkurt N, Ayvaz G, Akturk M
Arch Gynecol Obstet 2015 Apr;291(4):933-7. Epub 2014 Sep 27 doi: 10.1007/s00404-014-3490-3. PMID: 25260988
Serum fetuin-A concentration and fetuin-A-containing calciprotein particles in patients with chronic inflammatory disease and renal failure.
Smith ER, Cai MM, McMahon LP, Pedagogos E, Toussaint ND, Brumby C, Holt SG
Nephrology (Carlton) 2013 Mar;18(3):215-21. doi: 10.1111/nep.12021. PMID: 23231493
Circulating fetuin-A predicts early mortality in chronic hemodialysis patients.
Bláha V, Mistrík E, Dusilová-Sulková S, Kalousová M, Andrýs C, Bláha M, Sobotka L
Clin Biochem 2009 Jul;42(10-11):996-1000. Epub 2009 Mar 31 doi: 10.1016/j.clinbiochem.2009.03.021. PMID: 19341719

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