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Thromboinflammation

MedGen UID:
1785620
Concept ID:
C5544452
Disease or Syndrome
Synonym: Immunothrombosis

Definition

Thrombosis with associated inflammation due to crosstalk between HEMOSTASIS and INNATE IMMUNE RESPONSES modulated by PLATELETS. It is associated with many diseases such as COVID-19; SICKLE CELL ANEMIA; and THROMBOPHLEBITIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThromboinflammation

Professional guidelines

PubMed

Dobie G
Clin Lab 2023 Jul 1;69(7) doi: 10.7754/Clin.Lab.2023.221006. PMID: 37436376
Chiang KC, Rizk JG, Nelson DJ, Krishnamurti L, Subbian S, Imig JD, Khan I, Reddy ST, Gupta A
Expert Opin Ther Targets 2022 Jan;26(1):13-28. Epub 2022 Feb 22 doi: 10.1080/14728222.2022.2031975. PMID: 35068281Free PMC Article
Ten Cate H, Guzik TJ, Eikelboom J, Spronk HMH
Cardiovasc Res 2021 Jul 27;117(9):2030-2044. doi: 10.1093/cvr/cvaa263. PMID: 32931586Free PMC Article

Recent clinical studies

Etiology

Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S
Immunity 2022 Dec 13;55(12):2285-2299.e7. Epub 2022 Oct 21 doi: 10.1016/j.immuni.2022.10.001. PMID: 36272416Free PMC Article
Dix C, Zeller J, Stevens H, Eisenhardt SU, Shing KSCT, Nero TL, Morton CJ, Parker MW, Peter K, McFadyen JD
Front Immunol 2022;13:1002652. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.1002652. PMID: 36177015Free PMC Article
Scozzi D, Liao F, Krupnick AS, Kreisel D, Gelman AE
Front Immunol 2022;13:953195. Epub 2022 Jul 29 doi: 10.3389/fimmu.2022.953195. PMID: 35967320Free PMC Article
Stark K, Massberg S
Nat Rev Cardiol 2021 Sep;18(9):666-682. Epub 2021 May 6 doi: 10.1038/s41569-021-00552-1. PMID: 33958774Free PMC Article
van der Meijden PEJ, Heemskerk JWM
Nat Rev Cardiol 2019 Mar;16(3):166-179. doi: 10.1038/s41569-018-0110-0. PMID: 30429532

Diagnosis

Cervia-Hasler C, Brüningk SC, Hoch T, Fan B, Muzio G, Thompson RC, Ceglarek L, Meledin R, Westermann P, Emmenegger M, Taeschler P, Zurbuchen Y, Pons M, Menges D, Ballouz T, Cervia-Hasler S, Adamo S, Merad M, Charney AW, Puhan M, Brodin P, Nilsson J, Aguzzi A, Raeber ME, Messner CB, Beckmann ND, Borgwardt K, Boyman O
Science 2024 Jan 19;383(6680):eadg7942. doi: 10.1126/science.adg7942. PMID: 38236961
Marsh PL, Moore EE, Moore HB, Bunch CM, Aboukhaled M, Condon SM 2nd, Al-Fadhl MD, Thomas SJ, Larson JR, Bower CW, Miller CB, Pearson ML, Twilling CL, Reser DW, Kim GS, Troyer BM, Yeager D, Thomas SG, Srikureja DP, Patel SS, Añón SL, Thomas AV, Miller JB, Van Ryn DE, Pamulapati SV, Zimmerman D, Wells B, Martin PL, Seder CW, Aversa JG, Greene RB, March RJ, Kwaan HC, Fulkerson DH, Vande Lune SA, Mollnes TE, Nielsen EW, Storm BS, Walsh MM
Front Immunol 2023;14:1230049. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1230049. PMID: 37795086Free PMC Article
Knight JS, Kanthi Y
Semin Immunopathol 2022 May;44(3):347-362. Epub 2022 Feb 4 doi: 10.1007/s00281-022-00916-w. PMID: 35122116Free PMC Article
Xourgia E, Tektonidou MG
Curr Rheumatol Rep 2022 Jan 5;23(12):84. doi: 10.1007/s11926-021-01051-5. PMID: 34985625
Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, Bikdeli B, Ahluwalia N, Ausiello JC, Wan EY, Freedberg DE, Kirtane AJ, Parikh SA, Maurer MS, Nordvig AS, Accili D, Bathon JM, Mohan S, Bauer KA, Leon MB, Krumholz HM, Uriel N, Mehra MR, Elkind MSV, Stone GW, Schwartz A, Ho DD, Bilezikian JP, Landry DW
Nat Med 2020 Jul;26(7):1017-1032. Epub 2020 Jul 10 doi: 10.1038/s41591-020-0968-3. PMID: 32651579

Therapy

Iba T, Helms J, Levi M, Levy JH
J Thromb Haemost 2024 Jan;22(1):7-22. Epub 2023 Aug 3 doi: 10.1016/j.jtha.2023.07.020. PMID: 37541590
Greinacher A, Warkentin TE
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):1-10. doi: 10.1182/hematology.2023000503. PMID: 38066843Free PMC Article
Stark K, Massberg S
Nat Rev Cardiol 2021 Sep;18(9):666-682. Epub 2021 May 6 doi: 10.1038/s41569-021-00552-1. PMID: 33958774Free PMC Article
Jackson SP, Darbousset R, Schoenwaelder SM
Blood 2019 Feb 28;133(9):906-918. Epub 2019 Jan 14 doi: 10.1182/blood-2018-11-882993. PMID: 30642917
van der Meijden PEJ, Heemskerk JWM
Nat Rev Cardiol 2019 Mar;16(3):166-179. doi: 10.1038/s41569-018-0110-0. PMID: 30429532

Prognosis

Marsh PL, Moore EE, Moore HB, Bunch CM, Aboukhaled M, Condon SM 2nd, Al-Fadhl MD, Thomas SJ, Larson JR, Bower CW, Miller CB, Pearson ML, Twilling CL, Reser DW, Kim GS, Troyer BM, Yeager D, Thomas SG, Srikureja DP, Patel SS, Añón SL, Thomas AV, Miller JB, Van Ryn DE, Pamulapati SV, Zimmerman D, Wells B, Martin PL, Seder CW, Aversa JG, Greene RB, March RJ, Kwaan HC, Fulkerson DH, Vande Lune SA, Mollnes TE, Nielsen EW, Storm BS, Walsh MM
Front Immunol 2023;14:1230049. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1230049. PMID: 37795086Free PMC Article
Maneta E, Aivalioti E, Tual-Chalot S, Emini Veseli B, Gatsiou A, Stamatelopoulos K, Stellos K
Front Immunol 2023;14:1144229. Epub 2023 Apr 4 doi: 10.3389/fimmu.2023.1144229. PMID: 37081895Free PMC Article
Dix C, Zeller J, Stevens H, Eisenhardt SU, Shing KSCT, Nero TL, Morton CJ, Parker MW, Peter K, McFadyen JD
Front Immunol 2022;13:1002652. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.1002652. PMID: 36177015Free PMC Article
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
Xourgia E, Tektonidou MG
Curr Rheumatol Rep 2022 Jan 5;23(12):84. doi: 10.1007/s11926-021-01051-5. PMID: 34985625

Clinical prediction guides

Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K
JCI Insight 2023 Nov 22;8(22) doi: 10.1172/jci.insight.171054. PMID: 37991024Free PMC Article
Vagionas D, Papadakis DD, Politou M, Koutsoukou A, Vasileiadis I
In Vivo 2022 Nov-Dec;36(6):2542-2557. doi: 10.21873/invivo.12991. PMID: 36309378Free PMC Article
Dix C, Zeller J, Stevens H, Eisenhardt SU, Shing KSCT, Nero TL, Morton CJ, Parker MW, Peter K, McFadyen JD
Front Immunol 2022;13:1002652. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.1002652. PMID: 36177015Free PMC Article
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
Ribes A, Vardon-Bounes F, Mémier V, Poette M, Au-Duong J, Garcia C, Minville V, Sié P, Bura-Rivière A, Voisin S, Payrastre B
Adv Biol Regul 2020 Aug;77:100735. Epub 2020 Jun 17 doi: 10.1016/j.jbior.2020.100735. PMID: 32773098Free PMC Article

Recent systematic reviews

Ligi D, Della Franca C, Notarte KI, Goldrich N, Kavteladze D, Henry BM, Mannello F
Clin Chem Lab Med 2024 Feb 26;62(3):385-395. Epub 2023 Sep 20 doi: 10.1515/cclm-2023-0625. PMID: 37725416
Ligi D, Lo Sasso B, Henry BM, Ciaccio M, Lippi G, Plebani M, Mannello F
Clin Chem Lab Med 2023 May 25;61(6):960-973. Epub 2023 Jan 11 doi: 10.1515/cclm-2022-0936. PMID: 36626568
Ligi D, Giglio RV, Henry BM, Lippi G, Ciaccio M, Plebani M, Mannello F
Clin Chem Lab Med 2022 Sep 27;60(10):1506-1517. Epub 2022 Jul 19 doi: 10.1515/cclm-2022-0574. PMID: 35852070
Garred P, Tenner AJ, Mollnes TE
Pharmacol Rev 2021 Apr;73(2):792-827. doi: 10.1124/pharmrev.120.000072. PMID: 33687995Free PMC Article
Dou Q, Wei X, Zhou K, Yang S, Jia P
Trends Endocrinol Metab 2020 Dec;31(12):893-904. Epub 2020 Oct 16 doi: 10.1016/j.tem.2020.10.001. PMID: 33172748Free PMC Article

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