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Thromboinflammation

MedGen UID:
1785620
•Concept ID:
C5544452
•
Disease or Syndrome
Synonym: Immunothrombosis

Definition

Thrombosis with associated inflammation due to crosstalk between HEMOSTASIS and INNATE IMMUNE RESPONSES modulated by PLATELETS. It is associated with many diseases such as COVID-19; SICKLE CELL ANEMIA; and THROMBOPHLEBITIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThromboinflammation

Professional guidelines

PubMed

Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath.
Chiang KC, Rizk JG, Nelson DJ, Krishnamurti L, Subbian S, Imig JD, Khan I, Reddy ST, Gupta A
Expert Opin Ther Targets 2022 Jan;26(1):13-28. Epub 2022 Feb 22 doi: 10.1080/14728222.2022.2031975. PMID: 35068281Free PMC Article
Thrombo-inflammation in acute ischaemic stroke - implications for treatment.
Stoll G, Nieswandt B
Nat Rev Neurol 2019 Aug;15(8):473-481. Epub 2019 Jul 1 doi: 10.1038/s41582-019-0221-1. PMID: 31263257
An emerging role of neutrophils and NETosis in chronic inflammation and fibrosis in systemic lupus erythematosus (SLE) and ANCA-associated vasculitides (AAV): Implications for the pathogenesis and treatment.
Frangou E, Vassilopoulos D, Boletis J, Boumpas DT
Autoimmun Rev 2019 Aug;18(8):751-760. Epub 2019 Jun 8 doi: 10.1016/j.autrev.2019.06.011. PMID: 31181324

Recent clinical studies

Etiology

Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S
Immunity 2022 Dec 13;55(12):2285-2299.e7. Epub 2022 Oct 21 doi: 10.1016/j.immuni.2022.10.001. PMID: 36272416Free PMC Article
The role of neutrophil extracellular traps in acute lung injury.
Scozzi D, Liao F, Krupnick AS, Kreisel D, Gelman AE
Front Immunol 2022;13:953195. Epub 2022 Jul 29 doi: 10.3389/fimmu.2022.953195. PMID: 35967320Free PMC Article
Interplay between inflammation and thrombosis in cardiovascular pathology.
Stark K, Massberg S
Nat Rev Cardiol 2021 Sep;18(9):666-682. Epub 2021 May 6 doi: 10.1038/s41569-021-00552-1. PMID: 33958774Free PMC Article
Cardiovascular Manifestations and Mechanisms in Patients with COVID-19.
Dou Q, Wei X, Zhou K, Yang S, Jia P
Trends Endocrinol Metab 2020 Dec;31(12):893-904. Epub 2020 Oct 16 doi: 10.1016/j.tem.2020.10.001. PMID: 33172748Free PMC Article
Platelet biology and functions: new concepts and clinical perspectives.
van der Meijden PEJ, Heemskerk JWM
Nat Rev Cardiol 2019 Mar;16(3):166-179. doi: 10.1038/s41569-018-0110-0. PMID: 30429532

Diagnosis

Platelet lipid metabolism in vascular thrombo-inflammation.
Manke MC, Ahrends R, Borst O
Pharmacol Ther 2022 Sep;237:108258. Epub 2022 Jul 29 doi: 10.1016/j.pharmthera.2022.108258. PMID: 35908612
Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome.
Knight JS, Kanthi Y
Semin Immunopathol 2022 May;44(3):347-362. Epub 2022 Feb 4 doi: 10.1007/s00281-022-00916-w. PMID: 35122116Free PMC Article
An Update on Antiphospholipid Syndrome.
Xourgia E, Tektonidou MG
Curr Rheumatol Rep 2022 Jan 5;23(12):84. doi: 10.1007/s11926-021-01051-5. PMID: 34985625
Venous Thromboembolism in COVID-19.
Schulman S, Hu Y, Konstantinides S
Thromb Haemost 2020 Dec;120(12):1642-1653. Epub 2020 Oct 24 doi: 10.1055/s-0040-1718532. PMID: 33099284Free PMC Article
Extrapulmonary manifestations of COVID-19.
Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, Bikdeli B, Ahluwalia N, Ausiello JC, Wan EY, Freedberg DE, Kirtane AJ, Parikh SA, Maurer MS, Nordvig AS, Accili D, Bathon JM, Mohan S, Bauer KA, Leon MB, Krumholz HM, Uriel N, Mehra MR, Elkind MSV, Stone GW, Schwartz A, Ho DD, Bilezikian JP, Landry DW
Nat Med 2020 Jul;26(7):1017-1032. Epub 2020 Jul 10 doi: 10.1038/s41591-020-0968-3. PMID: 32651579

Therapy

Pathophysiology of coronavirus-19 disease acute lung injury.
Camporota L, Cronin JN, Busana M, Gattinoni L, Formenti F
Curr Opin Crit Care 2022 Feb 1;28(1):9-16. doi: 10.1097/MCC.0000000000000911. PMID: 34907979Free PMC Article
COVID-19: Thrombosis, thromboinflammation, and anticoagulation considerations.
Levy JH, Iba T, Olson LB, Corey KM, Ghadimi K, Connors JM
Int J Lab Hematol 2021 Jul;43 Suppl 1(Suppl 1):29-35. doi: 10.1111/ijlh.13500. PMID: 34288441Free PMC Article
Interplay between inflammation and thrombosis in cardiovascular pathology.
Stark K, Massberg S
Nat Rev Cardiol 2021 Sep;18(9):666-682. Epub 2021 May 6 doi: 10.1038/s41569-021-00552-1. PMID: 33958774Free PMC Article
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms.
Jackson SP, Darbousset R, Schoenwaelder SM
Blood 2019 Feb 28;133(9):906-918. Epub 2019 Jan 14 doi: 10.1182/blood-2018-11-882993. PMID: 30642917
Platelet biology and functions: new concepts and clinical perspectives.
van der Meijden PEJ, Heemskerk JWM
Nat Rev Cardiol 2019 Mar;16(3):166-179. doi: 10.1038/s41569-018-0110-0. PMID: 30429532

Prognosis

C-reactive protein, immunothrombosis and venous thromboembolism.
Dix C, Zeller J, Stevens H, Eisenhardt SU, Shing KSCT, Nero TL, Morton CJ, Parker MW, Peter K, McFadyen JD
Front Immunol 2022;13:1002652. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.1002652. PMID: 36177015Free PMC Article
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship.
D'Ardes D, Boccatonda A, Cocco G, Fabiani S, Rossi I, Bucci M, Guagnano MT, Schiavone C, Cipollone F
World J Gastroenterol 2022 Mar 21;28(11):1102-1112. doi: 10.3748/wjg.v28.i11.1102. PMID: 35431501Free PMC Article
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
An Update on Antiphospholipid Syndrome.
Xourgia E, Tektonidou MG
Curr Rheumatol Rep 2022 Jan 5;23(12):84. doi: 10.1007/s11926-021-01051-5. PMID: 34985625
Venous Thromboembolism in COVID-19.
Schulman S, Hu Y, Konstantinides S
Thromb Haemost 2020 Dec;120(12):1642-1653. Epub 2020 Oct 24 doi: 10.1055/s-0040-1718532. PMID: 33099284Free PMC Article

Clinical prediction guides

Thromboinflammation in Sepsis and Heparin: A Review of Literature and Pathophysiology.
Vagionas D, Papadakis DD, Politou M, Koutsoukou A, Vasileiadis I
In Vivo 2022 Nov-Dec;36(6):2542-2557. doi: 10.21873/invivo.12991. PMID: 36309378Free PMC Article
C-reactive protein, immunothrombosis and venous thromboembolism.
Dix C, Zeller J, Stevens H, Eisenhardt SU, Shing KSCT, Nero TL, Morton CJ, Parker MW, Peter K, McFadyen JD
Front Immunol 2022;13:1002652. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.1002652. PMID: 36177015Free PMC Article
Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity.
Iwamura C, Hirahara K, Kiuchi M, Ikehara S, Azuma K, Shimada T, Kuriyama S, Ohki S, Yamamoto E, Inaba Y, Shiko Y, Aoki A, Kokubo K, Hirasawa R, Hishiya T, Tsuji K, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Tsukamoto T, Nakamura S, Urushibara T, Kaneda S, Sakao S, Tobiume M, Suzuki Y, Tsujiwaki M, Kubo T, Hasegawa T, Nakase H, Nishida O, Takahashi K, Baba K, Iizumi Y, Okazaki T, Kimura MY, Yoshino I, Igari H, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Ikehara Y, Yokote K, Nakayama T
Proc Natl Acad Sci U S A 2022 Aug 16;119(33):e2203437119. Epub 2022 Jul 27 doi: 10.1073/pnas.2203437119. PMID: 35895716Free PMC Article
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship.
D'Ardes D, Boccatonda A, Cocco G, Fabiani S, Rossi I, Bucci M, Guagnano MT, Schiavone C, Cipollone F
World J Gastroenterol 2022 Mar 21;28(11):1102-1112. doi: 10.3748/wjg.v28.i11.1102. PMID: 35431501Free PMC Article
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article

Recent systematic reviews

Deciphering the role of monocyte and monocyte distribution width (MDW) in COVID-19: an updated systematic review and meta-analysis.
Ligi D, Lo Sasso B, Henry BM, Ciaccio M, Lippi G, Plebani M, Mannello F
Clin Chem Lab Med 2023 May 25;61(6):960-973. Epub 2023 Jan 11 doi: 10.1515/cclm-2022-0936. PMID: 36626568
Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review.
Cho J, Lee J, Sia CH, Koo CS, Tan BYQ, Hong W, Choi E, Goh X, Chai L, Chandran NS, Chua HR, L Chan BP, Muthiah M, Low TT, Yap ES, Lahiri M
Singapore Med J 2023 Jun;64(6):349-365. doi: 10.11622/smedj.2021100. PMID: 34544216Free PMC Article
What is the impact of circulating histones in COVID-19: a systematic review.
Ligi D, Giglio RV, Henry BM, Lippi G, Ciaccio M, Plebani M, Mannello F
Clin Chem Lab Med 2022 Sep 27;60(10):1506-1517. Epub 2022 Jul 19 doi: 10.1515/cclm-2022-0574. PMID: 35852070
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics.
Garred P, Tenner AJ, Mollnes TE
Pharmacol Rev 2021 Apr;73(2):792-827. doi: 10.1124/pharmrev.120.000072. PMID: 33687995Free PMC Article
Cardiovascular Manifestations and Mechanisms in Patients with COVID-19.
Dou Q, Wei X, Zhou K, Yang S, Jia P
Trends Endocrinol Metab 2020 Dec;31(12):893-904. Epub 2020 Oct 16 doi: 10.1016/j.tem.2020.10.001. PMID: 33172748Free PMC Article

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