U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VGLL2 Gene Rearrangement

MedGen UID:
1785686
•Concept ID:
C5446900
•
Cell or Molecular Dysfunction
Synonyms: Vestigial Like Family Member 2 Gene Rearrangement; VGL-2 Gene Rearrangement; VGL2 Gene Rearrangement; VGLL2 Rearrangement; VITO1 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the VGLL2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVGLL2 Gene Rearrangement

Recent clinical studies

Etiology

Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease: A Study of 4 Aggressive Cases With Clinical, Pathologic, Molecular, and Radiologic Findings.
Cyrta J, Gauthier A, Karanian M, Vieira AF, Cardoen L, Jehanno N, Bouvet M, Bouvier C, Komuta M, Le Loarer F, Orbach D, Rome A, Minard-Colin V, Brichard B, Pluchart C, Thebaud E, Renard M, Pannier S, Brisse H, Petit P, Benoist C, Schleiermacher G, Geoerger B, Vincent-Salomon A, Fréneaux P, Pierron G
Am J Surg Pathol 2021 Jun 1;45(6):854-867. doi: 10.1097/PAS.0000000000001702. PMID: 33949344
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.
Alaggio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, Zin A, Agaram NP, LaQuaglia MP, Wexler LH, Antonescu CR
Am J Surg Pathol 2016 Feb;40(2):224-35. doi: 10.1097/PAS.0000000000000538. PMID: 26501226Free PMC Article

Diagnosis

Congenital spindle cell rhabdomyosarcoma: An international cooperative analysis.
Whittle S, Venkatramani R, Schönstein A, Pack SD, Alaggio R, Vokuhl C, Rudzinski ER, Wulf AL, Zin A, Gruver JR, Arnold MA, Merks JHM, Hettmer S, Koscielniak E, Barr FG, Hawkins DS, Bisogno G, Sparber-Sauer M
Eur J Cancer 2022 Jun;168:56-64. Epub 2022 Apr 19 doi: 10.1016/j.ejca.2022.03.022. PMID: 35452896Free PMC Article
Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease: A Study of 4 Aggressive Cases With Clinical, Pathologic, Molecular, and Radiologic Findings.
Cyrta J, Gauthier A, Karanian M, Vieira AF, Cardoen L, Jehanno N, Bouvet M, Bouvier C, Komuta M, Le Loarer F, Orbach D, Rome A, Minard-Colin V, Brichard B, Pluchart C, Thebaud E, Renard M, Pannier S, Brisse H, Petit P, Benoist C, Schleiermacher G, Geoerger B, Vincent-Salomon A, Fréneaux P, Pierron G
Am J Surg Pathol 2021 Jun 1;45(6):854-867. doi: 10.1097/PAS.0000000000001702. PMID: 33949344

Prognosis

Congenital spindle cell rhabdomyosarcoma: An international cooperative analysis.
Whittle S, Venkatramani R, Schönstein A, Pack SD, Alaggio R, Vokuhl C, Rudzinski ER, Wulf AL, Zin A, Gruver JR, Arnold MA, Merks JHM, Hettmer S, Koscielniak E, Barr FG, Hawkins DS, Bisogno G, Sparber-Sauer M
Eur J Cancer 2022 Jun;168:56-64. Epub 2022 Apr 19 doi: 10.1016/j.ejca.2022.03.022. PMID: 35452896Free PMC Article
Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease: A Study of 4 Aggressive Cases With Clinical, Pathologic, Molecular, and Radiologic Findings.
Cyrta J, Gauthier A, Karanian M, Vieira AF, Cardoen L, Jehanno N, Bouvet M, Bouvier C, Komuta M, Le Loarer F, Orbach D, Rome A, Minard-Colin V, Brichard B, Pluchart C, Thebaud E, Renard M, Pannier S, Brisse H, Petit P, Benoist C, Schleiermacher G, Geoerger B, Vincent-Salomon A, Fréneaux P, Pierron G
Am J Surg Pathol 2021 Jun 1;45(6):854-867. doi: 10.1097/PAS.0000000000001702. PMID: 33949344
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.
Alaggio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, Zin A, Agaram NP, LaQuaglia MP, Wexler LH, Antonescu CR
Am J Surg Pathol 2016 Feb;40(2):224-35. doi: 10.1097/PAS.0000000000000538. PMID: 26501226Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...