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Fibrocellular crescent

MedGen UID:
1785763
•Concept ID:
C5539511
•
Finding
HPO: HP:0033318

Definition

A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrocellular crescent

Professional guidelines

PubMed

Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510

Recent clinical studies

Etiology

Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510
Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.
Mohd R, Mohammad Kazmin NE, Abdul Cader R, Abd Shukor N, Wong YP, Shah SA, Alfian N
PLoS One 2021;16(4):e0249592. Epub 2021 Apr 8 doi: 10.1371/journal.pone.0249592. PMID: 33831052Free PMC Article
A validation study of crescents in predicting ESRD in patients with IgA nephropathy.
Zhang X, Shi S, Ouyang Y, Yang M, Shi M, Pan X, Lv J, Wang Z, Ren H, Shen P, Wang W, Zhang H, Xie J, Chen N
J Transl Med 2018 May 3;16(1):115. doi: 10.1186/s12967-018-1488-5. PMID: 29724226Free PMC Article
Immunosuppressive therapy for active IgA nephropathy is effective and safe, even in "elderly" patients.
Fukuda M, Hotta O, Mizuno M, Ogiyama Y, Ohte N
Clin Exp Nephrol 2016 Dec;20(6):832-834. Epub 2016 Jul 21 doi: 10.1007/s10157-016-1314-4. PMID: 27443481
Clinicopathological features and risk factors analysis of IgA nephropathy associated with acute kidney injury.
Zhang L, Li J, Yang S, Huang N, Zhou Q, Yang Q, Yu X
Ren Fail 2016 Jun;38(5):799-805. Epub 2016 Apr 6 doi: 10.3109/0886022X.2016.1163153. PMID: 27050722

Diagnosis

Coagulation potential in pediatric patients with immunoglobulin A nephropathy.
Omae T, Ishikawa T, Nakajima Y, Nogami K
Pediatr Int 2022 Jan;64(1):e15042. doi: 10.1111/ped.15042. PMID: 34699659
Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510
Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.
Mohd R, Mohammad Kazmin NE, Abdul Cader R, Abd Shukor N, Wong YP, Shah SA, Alfian N
PLoS One 2021;16(4):e0249592. Epub 2021 Apr 8 doi: 10.1371/journal.pone.0249592. PMID: 33831052Free PMC Article
A validation study of crescents in predicting ESRD in patients with IgA nephropathy.
Zhang X, Shi S, Ouyang Y, Yang M, Shi M, Pan X, Lv J, Wang Z, Ren H, Shen P, Wang W, Zhang H, Xie J, Chen N
J Transl Med 2018 May 3;16(1):115. doi: 10.1186/s12967-018-1488-5. PMID: 29724226Free PMC Article
Monoclonal IgG1κ anti-glomerular basement membrane disease: a case report.
Coley SM, Shirazian S, Radhakrishnan J, D'Agati VD
Am J Kidney Dis 2015 Feb;65(2):322-6. Epub 2014 Oct 22 doi: 10.1053/j.ajkd.2014.08.022. PMID: 25446021

Therapy

Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510
Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.
Mohd R, Mohammad Kazmin NE, Abdul Cader R, Abd Shukor N, Wong YP, Shah SA, Alfian N
PLoS One 2021;16(4):e0249592. Epub 2021 Apr 8 doi: 10.1371/journal.pone.0249592. PMID: 33831052Free PMC Article
A validation study of crescents in predicting ESRD in patients with IgA nephropathy.
Zhang X, Shi S, Ouyang Y, Yang M, Shi M, Pan X, Lv J, Wang Z, Ren H, Shen P, Wang W, Zhang H, Xie J, Chen N
J Transl Med 2018 May 3;16(1):115. doi: 10.1186/s12967-018-1488-5. PMID: 29724226Free PMC Article
Immunosuppressive therapy for active IgA nephropathy is effective and safe, even in "elderly" patients.
Fukuda M, Hotta O, Mizuno M, Ogiyama Y, Ohte N
Clin Exp Nephrol 2016 Dec;20(6):832-834. Epub 2016 Jul 21 doi: 10.1007/s10157-016-1314-4. PMID: 27443481
Myeloperoxidase-antineutrophil cytoplasmic antibody-related crescentic glomerulonephritis after treatment for clinically amyopathic dermatomyositis: a coincidental combination or not?
Kawai H, Kitagawa W, Suzuki N, Maeda K, Suzuki K, Miura N, Morita H, Banno S, Yamamura M, Imai H
Clin Exp Nephrol 2011 Aug;15(4):577-81. Epub 2011 Mar 25 doi: 10.1007/s10157-011-0432-2. PMID: 21431898

Prognosis

Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510
Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.
Mohd R, Mohammad Kazmin NE, Abdul Cader R, Abd Shukor N, Wong YP, Shah SA, Alfian N
PLoS One 2021;16(4):e0249592. Epub 2021 Apr 8 doi: 10.1371/journal.pone.0249592. PMID: 33831052Free PMC Article
A validation study of crescents in predicting ESRD in patients with IgA nephropathy.
Zhang X, Shi S, Ouyang Y, Yang M, Shi M, Pan X, Lv J, Wang Z, Ren H, Shen P, Wang W, Zhang H, Xie J, Chen N
J Transl Med 2018 May 3;16(1):115. doi: 10.1186/s12967-018-1488-5. PMID: 29724226Free PMC Article
Monoclonal IgG1κ anti-glomerular basement membrane disease: a case report.
Coley SM, Shirazian S, Radhakrishnan J, D'Agati VD
Am J Kidney Dis 2015 Feb;65(2):322-6. Epub 2014 Oct 22 doi: 10.1053/j.ajkd.2014.08.022. PMID: 25446021
Glomerular density in renal biopsy specimens predicts the long-term prognosis of IgA nephropathy.
Tsuboi N, Kawamura T, Koike K, Okonogi H, Hirano K, Hamaguchi A, Miyazaki Y, Ogura M, Joh K, Utsunomiya Y, Hosoya T
Clin J Am Soc Nephrol 2010 Jan;5(1):39-44. Epub 2009 Nov 19 doi: 10.2215/CJN.04680709. PMID: 19965542Free PMC Article

Clinical prediction guides

Coagulation potential in pediatric patients with immunoglobulin A nephropathy.
Omae T, Ishikawa T, Nakajima Y, Nogami K
Pediatr Int 2022 Jan;64(1):e15042. doi: 10.1111/ped.15042. PMID: 34699659
Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy.
Nagai M, Kobayashi N, Izumi N, Ohbayashi T, Hotta O, Hamano T
J Nephrol 2022 Mar;35(2):441-449. Epub 2021 May 20 doi: 10.1007/s40620-021-01064-4. PMID: 34014510
Long term outcome of immunoglobulin A (IgA) nephropathy: A single center experience.
Mohd R, Mohammad Kazmin NE, Abdul Cader R, Abd Shukor N, Wong YP, Shah SA, Alfian N
PLoS One 2021;16(4):e0249592. Epub 2021 Apr 8 doi: 10.1371/journal.pone.0249592. PMID: 33831052Free PMC Article
A validation study of crescents in predicting ESRD in patients with IgA nephropathy.
Zhang X, Shi S, Ouyang Y, Yang M, Shi M, Pan X, Lv J, Wang Z, Ren H, Shen P, Wang W, Zhang H, Xie J, Chen N
J Transl Med 2018 May 3;16(1):115. doi: 10.1186/s12967-018-1488-5. PMID: 29724226Free PMC Article
Clinicopathological features and risk factors analysis of IgA nephropathy associated with acute kidney injury.
Zhang L, Li J, Yang S, Huang N, Zhou Q, Yang Q, Yu X
Ren Fail 2016 Jun;38(5):799-805. Epub 2016 Apr 6 doi: 10.3109/0886022X.2016.1163153. PMID: 27050722

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