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Visceral epithelial cell detachment

MedGen UID:
1786195
•Concept ID:
C5539445
•
Finding
Synonyms: Detachment of visceral epithelial cells; Podocyte detachment
 
HPO: HP:0033237

Definition

Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVisceral epithelial cell detachment

Professional guidelines

PubMed

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype.
Ekulu PM, Adebayo OC, Decuypere JP, Bellucci L, Elmonem MA, Nkoy AB, Mekahli D, Bussolati B, van den Heuvel LP, Arcolino FO, Levtchenko EN
Cells 2021 Jul 28;10(8) doi: 10.3390/cells10081914. PMID: 34440683Free PMC Article
Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020.
Ahn W, Bomback AS
Am J Kidney Dis 2020 Jun;75(6):955-964. Epub 2020 Apr 21 doi: 10.1053/j.ajkd.2019.12.019. PMID: 32331832
Podometrics as a Potential Clinical Tool for Glomerular Disease Management.
Kikuchi M, Wickman L, Hodgin JB, Wiggins RC
Semin Nephrol 2015 May;35(3):245-55. doi: 10.1016/j.semnephrol.2015.04.004. PMID: 26215862Free PMC Article

Recent clinical studies

Etiology

Detection of urinary podocytes by flow cytometry in idiopathic membranous nephropathy.
Mella A, Deambrosis I, Mingozzi S, Colla L, Burdese M, Giaretta F, Bruno S, Camussi G, Boaglio E, Dolla C, Clari R, Biancone L
Sci Rep 2020 Oct 1;10(1):16362. doi: 10.1038/s41598-020-73335-2. PMID: 33004982Free PMC Article
Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis.
Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, Tanaka E, Trejo JAO, Yamamoto-Nonaka K, Sasaki Y, Hidaka T, Ueno T, Yanagita M, Suzuki Y, Tomino Y, Asanuma K
Sci Rep 2018 Mar 22;8(1):5061. doi: 10.1038/s41598-018-23278-6. PMID: 29567961Free PMC Article
Next generation sequencing and functional analysis of patient urine renal progenitor-derived podocytes to unravel the diagnosis underlying refractory lupus nephritis.
Romagnani P, Giglio S, Angelotti ML, Provenzano A, Becherucci F, Mazzinghi B, Müller S, Amann K, Weidenbusch M, Romoli S, Lazzeri E, Anders HJ
Nephrol Dial Transplant 2016 Sep;31(9):1541-5. Epub 2016 Jun 19 doi: 10.1093/ndt/gfw234. PMID: 27325253
Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis.
Kachurina N, Chung CF, Benderoff E, Babayeva S, Bitzan M, Goodyer P, Kitzler T, Matar D, Cybulsky AV, Alachkar N, Torban E
Am J Physiol Renal Physiol 2016 May 15;310(10):F1148-56. Epub 2015 Dec 30 doi: 10.1152/ajprenal.00349.2015. PMID: 26719363
Podometrics as a Potential Clinical Tool for Glomerular Disease Management.
Kikuchi M, Wickman L, Hodgin JB, Wiggins RC
Semin Nephrol 2015 May;35(3):245-55. doi: 10.1016/j.semnephrol.2015.04.004. PMID: 26215862Free PMC Article

Diagnosis

Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020.
Ahn W, Bomback AS
Am J Kidney Dis 2020 Jun;75(6):955-964. Epub 2020 Apr 21 doi: 10.1053/j.ajkd.2019.12.019. PMID: 32331832
Podocytes from the diagnostic and therapeutic point of view.
Müller-Deile J, Schiffer M
Pflugers Arch 2017 Aug;469(7-8):1007-1015. Epub 2017 May 16 doi: 10.1007/s00424-017-1993-z. PMID: 28508947
Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis.
Kachurina N, Chung CF, Benderoff E, Babayeva S, Bitzan M, Goodyer P, Kitzler T, Matar D, Cybulsky AV, Alachkar N, Torban E
Am J Physiol Renal Physiol 2016 May 15;310(10):F1148-56. Epub 2015 Dec 30 doi: 10.1152/ajprenal.00349.2015. PMID: 26719363
WT1 immunoenzyme staining using SurePath(™) processed urine cytology helps to detect kidney disease.
Ohsaki H, Sofue T, Kawakami K, Nishijima Y, Hara T, Matsunaga T, Kushida Y, Haba R, Shigematsu Y, Irino S, Norimatsu Y
Cytopathology 2016 Feb;27(1):43-9. Epub 2015 Feb 14 doi: 10.1111/cyt.12227. PMID: 25683486
Nanostructural features of diabetic podocytopathy.
Mandache E, Penescu M
Rom J Morphol Embryol 2012;53(1):23-7. PMID: 22395495

Therapy

Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants.
Menon R, Otto EA, Berthier CC, Nair V, Farkash EA, Hodgin JB, Yang Y, Luo J, Woodside KJ, Zamani H, Norman SP, Wiggins RC, Kretzler M, Naik AS
Kidney Int 2022 Apr;101(4):779-792. Epub 2021 Dec 22 doi: 10.1016/j.kint.2021.11.031. PMID: 34952098Free PMC Article
Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
Feng D, Kumar M, Muntel J, Gurley SB, Birrane G, Stillman IE, Ding L, Wang M, Ahmed S, Schlondorff J, Alper SL, Ferrante T, Marquez SL, Ng CF, Novak R, Ingber DE, Steen H, Pollak MR
J Am Soc Nephrol 2020 Jul;31(7):1479-1495. Epub 2020 Jun 15 doi: 10.1681/ASN.2019101032. PMID: 32540856Free PMC Article
Direct Effects of Immunomodulatory Agents on Podocytes in Immune-Mediated Glomerular Diseases.
Manabe S, Nitta K, Nagata M
Contrib Nephrol 2018;195:131-142. Epub 2018 May 7 doi: 10.1159/000486943. PMID: 29734158
Assessment of detached podocytes in the Bowman's space as a marker of disease activity in lupus nephritis.
Moustafa FE, Soliman NA, Bakr AM, El Shwaf IM
Lupus 2014 Feb;23(2):146-50. Epub 2013 Dec 4 doi: 10.1177/0961203313514125. PMID: 24306541
A case of recurrent focal segmental glomerulosclerosis (FSGS) involving massive proteinuria (>50 g/day) immediately after renal transplantation.
Okamoto M, Koshino K, Sakai K, Nobori S, Matsuyama M, Ushigome H, Okajima H, Masuzawa N, Yoshimura N
Clin Transplant 2011 Jul;25 Suppl 23:53-8. doi: 10.1111/j.1399-0012.2011.01455.x. PMID: 21623916

Prognosis

Urinary Markers of Podocyte Dysfunction in Chronic Glomerulonephritis.
Chebotareva N, Bobkova I, Lysenko L, Moiseev S
Adv Exp Med Biol 2021;1306:81-99. doi: 10.1007/978-3-030-63908-2_6. PMID: 33959907
Detection of urinary podocytes by flow cytometry in idiopathic membranous nephropathy.
Mella A, Deambrosis I, Mingozzi S, Colla L, Burdese M, Giaretta F, Bruno S, Camussi G, Boaglio E, Dolla C, Clari R, Biancone L
Sci Rep 2020 Oct 1;10(1):16362. doi: 10.1038/s41598-020-73335-2. PMID: 33004982Free PMC Article
Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy.
Dai H, Liu Q, Liu B
J Diabetes Res 2017;2017:2615286. Epub 2017 Jul 16 doi: 10.1155/2017/2615286. PMID: 28791309Free PMC Article
Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy.
Fall B, Scott CR, Mauer M, Shankland S, Pippin J, Jefferson JA, Wallace E, Warnock D, Najafian B
PLoS One 2016;11(12):e0168346. Epub 2016 Dec 16 doi: 10.1371/journal.pone.0168346. PMID: 27992580Free PMC Article
Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis.
Kachurina N, Chung CF, Benderoff E, Babayeva S, Bitzan M, Goodyer P, Kitzler T, Matar D, Cybulsky AV, Alachkar N, Torban E
Am J Physiol Renal Physiol 2016 May 15;310(10):F1148-56. Epub 2015 Dec 30 doi: 10.1152/ajprenal.00349.2015. PMID: 26719363

Clinical prediction guides

Morphologic Analysis of Urinary Podocytes in Focal Segmental Glomerulosclerosis.
Shirai Y, Miura K, Yokoyama T, Horita S, Nakayama H, Seino H, Ando T, Shiratori A, Yabuuchi T, Kaneko N, Ishiwa S, Ishizuka K, Hara M, Hattori M
Kidney360 2021 Mar 25;2(3):477-486. Epub 2020 Dec 1 doi: 10.34067/KID.0005612020. PMID: 35369007Free PMC Article
Detection of urinary podocytes by flow cytometry in idiopathic membranous nephropathy.
Mella A, Deambrosis I, Mingozzi S, Colla L, Burdese M, Giaretta F, Bruno S, Camussi G, Boaglio E, Dolla C, Clari R, Biancone L
Sci Rep 2020 Oct 1;10(1):16362. doi: 10.1038/s41598-020-73335-2. PMID: 33004982Free PMC Article
Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis.
Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, Tanaka E, Trejo JAO, Yamamoto-Nonaka K, Sasaki Y, Hidaka T, Ueno T, Yanagita M, Suzuki Y, Tomino Y, Asanuma K
Sci Rep 2018 Mar 22;8(1):5061. doi: 10.1038/s41598-018-23278-6. PMID: 29567961Free PMC Article
Role of c-Abl and nephrin in podocyte cytoskeletal remodeling induced by angiotensin II.
Ma Y, Yang Q, Zhong Z, Liang W, Zhang L, Yang Y, Ding G
Cell Death Dis 2018 Feb 7;9(2):185. doi: 10.1038/s41419-017-0225-y. PMID: 29416010Free PMC Article
The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.
Sundararajan V, Gengenbacher N, Stemmler MP, Kleemann JA, Brabletz T, Brabletz S
Oncotarget 2015 Sep 29;6(29):27083-96. doi: 10.18632/oncotarget.4807. PMID: 26334100Free PMC Article

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