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Myxoid Pleomorphic Liposarcoma

MedGen UID:
1786865
•Concept ID:
C5447540
•
Neoplastic Process
Synonym: Pleomorphic Myxoid Liposarcoma

Definition

An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyxoid Pleomorphic Liposarcoma

Professional guidelines

PubMed

Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters.
Abaricia S, Hirbe AC
Curr Treat Options Oncol 2018 Oct 25;19(12):64. doi: 10.1007/s11864-018-0590-5. PMID: 30362022
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

Myxoid pleomorphic liposarcoma in the teres minor muscle: A case report.
Choi JH, Lee SH, Kim KS, Choi YD, Hwang JH, Lee SY
Medicine (Baltimore) 2022 Nov 4;101(44):e31360. doi: 10.1097/MD.0000000000031360. PMID: 36343027Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988

Diagnosis

Comprehensive genomic profiling of a unique liposarcoma arising in a patient with Li-Fraumeni syndrome and the novel detection of c-myc amplification: a case report.
Watanabe H, Fujishima F, Motoi T, Aoyama Y, Niihori T, Takahashi M, Umegaki S, Oishi H, Tada H, Ichinohasama R, Sasano H
Diagn Pathol 2022 Dec 13;17(1):93. doi: 10.1186/s13000-022-01264-x. PMID: 36514176Free PMC Article
Myxoid pleomorphic liposarcoma in the teres minor muscle: A case report.
Choi JH, Lee SH, Kim KS, Choi YD, Hwang JH, Lee SY
Medicine (Baltimore) 2022 Nov 4;101(44):e31360. doi: 10.1097/MD.0000000000031360. PMID: 36343027Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Primary liposarcoma of the mediastinum in a child.
Plukker JT, Joosten HJ, Rensing JB, Van Haelst UJ
J Surg Oncol 1988 Apr;37(4):257-63. doi: 10.1002/jso.2930370410. PMID: 3361919

Prognosis

Myxoid pleomorphic liposarcoma in the teres minor muscle: A case report.
Choi JH, Lee SH, Kim KS, Choi YD, Hwang JH, Lee SY
Medicine (Baltimore) 2022 Nov 4;101(44):e31360. doi: 10.1097/MD.0000000000031360. PMID: 36343027Free PMC Article
Liposarcoma in children and young adults: a clinicopathologic and molecular study of 23 cases in one of the largest institutions of China.
Peng R, Li N, Lan T, Chen H, Du T, He X, Chen M, Xie Y, Zhang Z, Zhao W, Zhang H
Virchows Arch 2021 Sep;479(3):537-549. Epub 2021 Mar 18 doi: 10.1007/s00428-021-03076-8. PMID: 33738541
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988

Clinical prediction guides

Myxoid pleomorphic liposarcoma in the teres minor muscle: A case report.
Choi JH, Lee SH, Kim KS, Choi YD, Hwang JH, Lee SY
Medicine (Baltimore) 2022 Nov 4;101(44):e31360. doi: 10.1097/MD.0000000000031360. PMID: 36343027Free PMC Article
Myxoid pleomorphic liposarcoma-a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma.
Creytens D, Folpe AL, Koelsche C, Mentzel T, Ferdinande L, van Gorp JM, Van der Linden M, Raman L, Menten B, Fritchie K, von Deimling A, Van Dorpe J, Flucke U
Mod Pathol 2021 Nov;34(11):2043-2049. Epub 2021 Jun 24 doi: 10.1038/s41379-021-00862-2. PMID: 34168281

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