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Elevated circulating myoglobin concentration

MedGen UID:
1787040
•Concept ID:
C5539591
•
Finding
HPO: HP:0033438

Definition

An increased blood concentration of myoglobin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating myoglobin concentration

Recent clinical studies

Etiology

Effect of a 2000-m running test on antioxidant and cytokine response in plasma and circulating cells.
Carrera-Quintanar L, Funes L, Sánchez-Martos M, Martinez-Peinado P, Sempere JM, Pons A, Micol V, Roche E
J Physiol Biochem 2017 Nov;73(4):523-530. Epub 2017 Jul 20 doi: 10.1007/s13105-017-0575-z. PMID: 28730509
Acute protease supplementation effects on muscle damage and recovery across consecutive days of cycle racing.
Shing CM, Chong S, Driller MW, Fell JW
Eur J Sport Sci 2016;16(2):206-12. Epub 2015 Jan 21 doi: 10.1080/17461391.2014.1001878. PMID: 25604346
Evaluation and comparison of soluble transferrin receptor in thalassemia carriers and iron deficient patients.
Khatami S, Dehnabeh SR, Mostafavi E, Kamalzadeh N, Yaghmaei P, Saeedi P, Shariat F, Bagheriyan H, Zeinali S, Akbari MT
Hemoglobin 2013;37(4):387-95. Epub 2013 Apr 12 doi: 10.3109/03630269.2013.780248. PMID: 23581600
Topical cooling (icing) delays recovery from eccentric exercise-induced muscle damage.
Tseng CY, Lee JP, Tsai YS, Lee SD, Kao CL, Liu TC, Lai C, Harris MB, Kuo CH
J Strength Cond Res 2013 May;27(5):1354-61. doi: 10.1519/JSC.0b013e318267a22c. PMID: 22820210
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538

Diagnosis

Evaluation and comparison of soluble transferrin receptor in thalassemia carriers and iron deficient patients.
Khatami S, Dehnabeh SR, Mostafavi E, Kamalzadeh N, Yaghmaei P, Saeedi P, Shariat F, Bagheriyan H, Zeinali S, Akbari MT
Hemoglobin 2013;37(4):387-95. Epub 2013 Apr 12 doi: 10.3109/03630269.2013.780248. PMID: 23581600
B-type natriuretic peptide signal peptide circulates in human blood: evaluation as a potential biomarker of cardiac ischemia.
Siriwardena M, Kleffmann T, Ruygrok P, Cameron VA, Yandle TG, Nicholls MG, Richards AM, Pemberton CJ
Circulation 2010 Jul 20;122(3):255-64. Epub 2010 Jul 6 doi: 10.1161/CIRCULATIONAHA.109.909937. PMID: 20606123
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein.
Van Nieuwenhoven FA, Kleine AH, Wodzig WH, Hermens WT, Kragten HA, Maessen JG, Punt CD, Van Dieijen MP, Van der Vusse GJ, Glatz JF
Circulation 1995 Nov 15;92(10):2848-54. doi: 10.1161/01.cir.92.10.2848. PMID: 7586251
Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time-activity curves for early assessment of coronary artery reperfusion after intravenous thrombolysis.
Zabel M, Hohnloser SH, Köster W, Prinz M, Kasper W, Just H
Circulation 1993 May;87(5):1542-50. doi: 10.1161/01.cir.87.5.1542. PMID: 8491009

Therapy

Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction.
Mohammad MA, Koul S, Egerstedt A, Smith JG, Noc M, Lang I, Holzer M, Clemmensen P, Gidlöf O, Metzler B, Engstrøm T, Erlinge D
Sci Rep 2020 Oct 29;10(1):18663. doi: 10.1038/s41598-020-75399-6. PMID: 33122738Free PMC Article
Effects of low-load resistance exercise with blood flow restriction on intramuscular hemodynamics, oxygenation level and water content.
Yanagisawa O, Fukutani A
J Sports Med Phys Fitness 2018 Jun;58(6):793-801. Epub 2017 May 9 doi: 10.23736/S0022-4707.17.07463-1. PMID: 28488836
Acute protease supplementation effects on muscle damage and recovery across consecutive days of cycle racing.
Shing CM, Chong S, Driller MW, Fell JW
Eur J Sport Sci 2016;16(2):206-12. Epub 2015 Jan 21 doi: 10.1080/17461391.2014.1001878. PMID: 25604346
Topical cooling (icing) delays recovery from eccentric exercise-induced muscle damage.
Tseng CY, Lee JP, Tsai YS, Lee SD, Kao CL, Liu TC, Lai C, Harris MB, Kuo CH
J Strength Cond Res 2013 May;27(5):1354-61. doi: 10.1519/JSC.0b013e318267a22c. PMID: 22820210
Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein.
Van Nieuwenhoven FA, Kleine AH, Wodzig WH, Hermens WT, Kragten HA, Maessen JG, Punt CD, Van Dieijen MP, Van der Vusse GJ, Glatz JF
Circulation 1995 Nov 15;92(10):2848-54. doi: 10.1161/01.cir.92.10.2848. PMID: 7586251

Prognosis

Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction.
Mohammad MA, Koul S, Egerstedt A, Smith JG, Noc M, Lang I, Holzer M, Clemmensen P, Gidlöf O, Metzler B, Engstrøm T, Erlinge D
Sci Rep 2020 Oct 29;10(1):18663. doi: 10.1038/s41598-020-75399-6. PMID: 33122738Free PMC Article
Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model.
Liu Y, Buerk DG, Barbee KA, Jaron D
Microvasc Res 2017 Jul;112:79-86. Epub 2017 Mar 28 doi: 10.1016/j.mvr.2017.03.009. PMID: 28363495Free PMC Article
The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy.
Li X, Luo R, Jiang R, Kong H, Tang Y, Shu Y, Hua W
Heart Lung 2014 May-Jun;43(3):219-24. doi: 10.1016/j.hrtlng.2014.03.001. PMID: 24794782
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time-activity curves for early assessment of coronary artery reperfusion after intravenous thrombolysis.
Zabel M, Hohnloser SH, Köster W, Prinz M, Kasper W, Just H
Circulation 1993 May;87(5):1542-50. doi: 10.1161/01.cir.87.5.1542. PMID: 8491009

Clinical prediction guides

Examination of Cognitive Function, Neurotrophin Concentrations, and both Brain and Systemic Inflammatory Markers Following a Simulated Game of American Football.
Hoffman JR, Ostfeld I, Zamir A, Amedi R, Fonville TR, Horstemeyer MF, Gepner Y
J Strength Cond Res 2022 Mar 1;36(3):686-694. doi: 10.1519/JSC.0000000000004218. PMID: 35180187
Effects of low-load resistance exercise with blood flow restriction on intramuscular hemodynamics, oxygenation level and water content.
Yanagisawa O, Fukutani A
J Sports Med Phys Fitness 2018 Jun;58(6):793-801. Epub 2017 May 9 doi: 10.23736/S0022-4707.17.07463-1. PMID: 28488836
Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model.
Liu Y, Buerk DG, Barbee KA, Jaron D
Microvasc Res 2017 Jul;112:79-86. Epub 2017 Mar 28 doi: 10.1016/j.mvr.2017.03.009. PMID: 28363495Free PMC Article
Evaluation and comparison of soluble transferrin receptor in thalassemia carriers and iron deficient patients.
Khatami S, Dehnabeh SR, Mostafavi E, Kamalzadeh N, Yaghmaei P, Saeedi P, Shariat F, Bagheriyan H, Zeinali S, Akbari MT
Hemoglobin 2013;37(4):387-95. Epub 2013 Apr 12 doi: 10.3109/03630269.2013.780248. PMID: 23581600
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538

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