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Hypertriglyceridemia 1(HYTG1)

MedGen UID:
1787149
•Concept ID:
C5444012
•
Disease or Syndrome
Synonym: Hypertriglyceridemia, familial
 
Gene (location): APOA5 (11q23.3)
 
Monarch Initiative: MONDO:0007788
OMIM®: 145750

Clinical features

From HPO
Precocious atherosclerosis
MedGen UID:
867292
•Concept ID:
C4021654
•
Pathologic Function
See: Feature record | Search on this feature
Hypopituitarism
MedGen UID:
9386
•Concept ID:
C0020635
•
Disease or Syndrome
A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
See: Feature record | Search on this feature
Glucose intolerance
MedGen UID:
75760
•Concept ID:
C0271650
•
Disease or Syndrome
Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).
See: Feature record | Search on this feature
Hypertriglyceridemia
MedGen UID:
167238
•Concept ID:
C0813230
•
Finding
An abnormal increase in the level of triglycerides in the blood.
See: Feature record | Search on this feature
Increased VLDL cholesterol concentration
MedGen UID:
867364
•Concept ID:
C4021729
•
Finding
An increase in the amount of very-low-density lipoprotein cholesterol in the blood.
See: Feature record | Search on this feature
Atheroeruptive xanthoma
MedGen UID:
871319
•Concept ID:
C4025807
•
Disease or Syndrome
See: Feature record | Search on this feature
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Professional guidelines

PubMed

The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: a review of the literature.
Ito MK
Atherosclerosis 2015 Oct;242(2):647-56. Epub 2015 Jun 11 doi: 10.1016/j.atherosclerosis.2015.06.012. PMID: 26296750
Diagnostic criteria in relation to the pathogenesis of familial combined hyperlipidemia.
de Graaf J, van der Vleuten G, Stalenhoef AF
Semin Vasc Med 2004 Aug;4(3):229-40. doi: 10.1055/s-2004-861490. PMID: 15630632

Recent clinical studies

Etiology

Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.
Tardif JC, Karwatowska-Prokopczuk E, Amour ES, Ballantyne CM, Shapiro MD, Moriarty PM, Baum SJ, Hurh E, Bartlett VJ, Kingsbury J, Figueroa AL, Alexander VJ, Tami J, Witztum JL, Geary RS, O'Dea LSL, Tsimikas S, Gaudet D
Eur Heart J 2022 Apr 6;43(14):1401-1412. doi: 10.1093/eurheartj/ehab820. PMID: 35025993Free PMC Article
Genomics of hypertriglyceridemia.
Tada H, Takamura M, Kawashiri MA
Adv Clin Chem 2020;97:141-169. Epub 2020 Feb 14 doi: 10.1016/bs.acc.2019.12.005. PMID: 32448433
Is hypertriglyceridemia atherogenic?
Roubille F, Sultan A, Huet F, Leclercq F, Macia JC, Gervasoni R, Delseny D, Akodad M, Roubille C
Presse Med 2018 Sep;47(9):757-763. Epub 2018 Sep 24 doi: 10.1016/j.lpm.2018.08.009. PMID: 30262206
Hypertriglyceridemia and atherosclerosis.
Peng J, Luo F, Ruan G, Peng R, Li X
Lipids Health Dis 2017 Dec 6;16(1):233. doi: 10.1186/s12944-017-0625-0. PMID: 29212549Free PMC Article
Pathophysiology of hypertriglyceridemia.
Hassing HC, Surendran RP, Mooij HL, Stroes ES, Nieuwdorp M, Dallinga-Thie GM
Biochim Biophys Acta 2012 May;1821(5):826-32. Epub 2011 Dec 10 doi: 10.1016/j.bbalip.2011.11.010. PMID: 22179026

Diagnosis

Hypertriglyceridaemia: a commentary.
Ryan A, Simpson WG, Twomey P
J Clin Pathol 2023 Jan;76(1):2-4. Epub 2022 Sep 27 doi: 10.1136/jcp-2022-208513. PMID: 36167730
Emerging Fixed-Dose Combination Treatments for Hyperlipidemia.
Pappa E, Rizos CV, Filippatos TD, Elisaf MS
J Cardiovasc Pharmacol Ther 2019 Jul;24(4):315-322. Epub 2019 Mar 25 doi: 10.1177/1074248419838506. PMID: 30909733
Congenital lipodystrophies and dyslipidemias.
Prieur X, Le May C, Magré J, Cariou B
Curr Atheroscler Rep 2014 Sep;16(9):437. doi: 10.1007/s11883-014-0437-x. PMID: 25047893
Primary and secondary hypertriglyceridaemia.
Kolovou GD, Anagnostopoulou KK, Kostakou PM, Bilianou H, Mikhailidis DP
Curr Drug Targets 2009 Apr;10(4):336-43. doi: 10.2174/138945009787846452. PMID: 19355858
Hypertriglyceridemia: impact and treatment.
Goldberg IJ
Endocrinol Metab Clin North Am 2009 Mar;38(1):137-49. doi: 10.1016/j.ecl.2008.11.005. PMID: 19217516

Therapy

Apolipoprotein C-III Inhibition - Killing Two Birds with One Stone?
Kraaijenhof JM, Stroes ESG
NEJM Evid 2023 Dec;2(12):EVIDe2300239. Epub 2023 Nov 28 doi: 10.1056/EVIDe2300239. PMID: 38320505
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.
Tardif JC, Karwatowska-Prokopczuk E, Amour ES, Ballantyne CM, Shapiro MD, Moriarty PM, Baum SJ, Hurh E, Bartlett VJ, Kingsbury J, Figueroa AL, Alexander VJ, Tami J, Witztum JL, Geary RS, O'Dea LSL, Tsimikas S, Gaudet D
Eur Heart J 2022 Apr 6;43(14):1401-1412. doi: 10.1093/eurheartj/ehab820. PMID: 35025993Free PMC Article
Genomics of hypertriglyceridemia.
Tada H, Takamura M, Kawashiri MA
Adv Clin Chem 2020;97:141-169. Epub 2020 Feb 14 doi: 10.1016/bs.acc.2019.12.005. PMID: 32448433
Is hypertriglyceridemia atherogenic?
Roubille F, Sultan A, Huet F, Leclercq F, Macia JC, Gervasoni R, Delseny D, Akodad M, Roubille C
Presse Med 2018 Sep;47(9):757-763. Epub 2018 Sep 24 doi: 10.1016/j.lpm.2018.08.009. PMID: 30262206
Cognition and nutrition.
Morley JE
Curr Opin Clin Nutr Metab Care 2014 Jan;17(1):1-4. doi: 10.1097/MCO.0000000000000005. PMID: 24310052

Prognosis

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.
Liang YY, Chen J, Peng M, Zhou J, Chen X, Tan X, Wang N, Ma H, Guo L, Zhang J, Wing YK, Geng Q, Ai S
J Transl Med 2023 Feb 7;21(1):90. doi: 10.1186/s12967-023-03920-2. PMID: 36747249Free PMC Article
Recent developments in pharmacotherapy for hypertriglyceridemia: what's the current state of the art?
Florentin M, Kostapanos MS, Anagnostis P, Liamis G
Expert Opin Pharmacother 2020 Jan;21(1):107-120. Epub 2019 Nov 18 doi: 10.1080/14656566.2019.1691523. PMID: 31738617
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators
N Engl J Med 2019 Jan 3;380(1):11-22. Epub 2018 Nov 10 doi: 10.1056/NEJMoa1812792. PMID: 30415628
Diabetic Ketoacidosis and the Domino Effect.
Shaikh BH, Sohaib M, Alshantti R, Barrera F, Faridi FS, Murvelashvili N
Am J Case Rep 2018 Nov 10;19:1342-1344. doi: 10.12659/AJCR.911747. PMID: 30413682Free PMC Article
HIV therapy, metabolic syndrome, and cardiovascular risk.
Pao V, Lee GA, Grunfeld C
Curr Atheroscler Rep 2008 Feb;10(1):61-70. doi: 10.1007/s11883-008-0010-6. PMID: 18366987Free PMC Article

Clinical prediction guides

Apolipoprotein C-III Inhibition - Killing Two Birds with One Stone?
Kraaijenhof JM, Stroes ESG
NEJM Evid 2023 Dec;2(12):EVIDe2300239. Epub 2023 Nov 28 doi: 10.1056/EVIDe2300239. PMID: 38320505
Mechanisms linking hypertriglyceridemia to acute pancreatitis.
Kiss L, Fűr G, Pisipati S, Rajalingamgari P, Ewald N, Singh V, Rakonczay Z Jr
Acta Physiol (Oxf) 2023 Mar;237(3):e13916. Epub 2023 Jan 13 doi: 10.1111/apha.13916. PMID: 36599412
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.
Tardif JC, Karwatowska-Prokopczuk E, Amour ES, Ballantyne CM, Shapiro MD, Moriarty PM, Baum SJ, Hurh E, Bartlett VJ, Kingsbury J, Figueroa AL, Alexander VJ, Tami J, Witztum JL, Geary RS, O'Dea LSL, Tsimikas S, Gaudet D
Eur Heart J 2022 Apr 6;43(14):1401-1412. doi: 10.1093/eurheartj/ehab820. PMID: 35025993Free PMC Article
Emerging Fixed-Dose Combination Treatments for Hyperlipidemia.
Pappa E, Rizos CV, Filippatos TD, Elisaf MS
J Cardiovasc Pharmacol Ther 2019 Jul;24(4):315-322. Epub 2019 Mar 25 doi: 10.1177/1074248419838506. PMID: 30909733
Pathophysiology of hypertriglyceridemia.
Hassing HC, Surendran RP, Mooij HL, Stroes ES, Nieuwdorp M, Dallinga-Thie GM
Biochim Biophys Acta 2012 May;1821(5):826-32. Epub 2011 Dec 10 doi: 10.1016/j.bbalip.2011.11.010. PMID: 22179026

Recent systematic reviews

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials.
Dadkhah Tehrani S, Shojaei M, Bagherniya M, Pirro M, Sahebkar A
Phytother Res 2023 Apr;37(4):1640-1662. Epub 2023 Feb 9 doi: 10.1002/ptr.7763. PMID: 36756995
Hypertriglyceridemia-Associated Drug-Induced Acute Pancreatitis.
Elkhouly MA, Salazar MJ, Simons-Linares CR
Pancreas 2019 Jan;48(1):22-35. doi: 10.1097/MPA.0000000000001190. PMID: 30531242
Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials.
Hadi A, Mohammadi H, Hadi Z, Roshanravan N, Kafeshani M
Phytother Res 2018 Nov;32(11):2146-2154. Epub 2018 Aug 8 doi: 10.1002/ptr.6162. PMID: 30088304
Bipolar disorder and metabolic syndrome: a systematic review.
Czepielewski L, Daruy Filho L, Brietzke E, Grassi-Oliveira R
Braz J Psychiatry 2013 Mar;35(1):88-93. doi: 10.1016/j.rbp.2012.07.004. PMID: 23567607
Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials.
Wycherley TP, Moran LJ, Clifton PM, Noakes M, Brinkworth GD
Am J Clin Nutr 2012 Dec;96(6):1281-98. Epub 2012 Oct 24 doi: 10.3945/ajcn.112.044321. PMID: 23097268

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