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Hypertriglyceridemia 1(HYTG1)

MedGen UID:
1787149
•Concept ID:
C5444012
•
Disease or Syndrome
Synonym: Hypertriglyceridemia, familial
 
Gene (location): APOA5 (11q23.3)
 
Monarch Initiative: MONDO:0007788
OMIM®: 145750

Clinical features

From HPO
Precocious atherosclerosis
MedGen UID:
867292
•Concept ID:
C4021654
•
Pathologic Function
See: Feature record | Search on this feature
Hypopituitarism
MedGen UID:
9386
•Concept ID:
C0020635
•
Disease or Syndrome
A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
See: Feature record | Search on this feature
Glucose intolerance
MedGen UID:
75760
•Concept ID:
C0271650
•
Disease or Syndrome
Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).
See: Feature record | Search on this feature
Hypertriglyceridemia
MedGen UID:
167238
•Concept ID:
C0813230
•
Finding
An abnormal increase in the level of triglycerides in the blood.
See: Feature record | Search on this feature
Increased VLDL cholesterol concentration
MedGen UID:
867364
•Concept ID:
C4021729
•
Finding
An increase in the amount of very-low-density lipoprotein cholesterol in the blood.
See: Feature record | Search on this feature
Atheroeruptive xanthoma
MedGen UID:
871319
•Concept ID:
C4025807
•
Disease or Syndrome
See: Feature record | Search on this feature
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Professional guidelines

PubMed

The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: a review of the literature.
Ito MK
Atherosclerosis 2015 Oct;242(2):647-56. Epub 2015 Jun 11 doi: 10.1016/j.atherosclerosis.2015.06.012. PMID: 26296750
Diagnostic criteria in relation to the pathogenesis of familial combined hyperlipidemia.
de Graaf J, van der Vleuten G, Stalenhoef AF
Semin Vasc Med 2004 Aug;4(3):229-40. doi: 10.1055/s-2004-861490. PMID: 15630632

Recent clinical studies

Etiology

Dyslipemias and pregnancy, an update.
Mauri M, Calmarza P, Ibarretxe D
Clin Investig Arterioscler 2021 Jan-Feb;33(1):41-52. Epub 2020 Dec 9 doi: 10.1016/j.arteri.2020.10.002. PMID: 33309071
Causes and Consequences of Hypertriglyceridemia.
Packard CJ, Boren J, Taskinen MR
Front Endocrinol (Lausanne) 2020;11:252. Epub 2020 May 14 doi: 10.3389/fendo.2020.00252. PMID: 32477261Free PMC Article
Clinical review on triglycerides.
Laufs U, Parhofer KG, Ginsberg HN, Hegele RA
Eur Heart J 2020 Jan 1;41(1):99-109c. doi: 10.1093/eurheartj/ehz785. PMID: 31764986Free PMC Article
Hypertriglyceridemia - Common Causes, Prevention and Treatment Strategies.
Rygiel K
Curr Cardiol Rev 2018 Mar 14;14(1):67-76. doi: 10.2174/1573403X14666180123165542. PMID: 29366425Free PMC Article
Hypertriglyceridemia and atherosclerosis.
Peng J, Luo F, Ruan G, Peng R, Li X
Lipids Health Dis 2017 Dec 6;16(1):233. doi: 10.1186/s12944-017-0625-0. PMID: 29212549Free PMC Article

Diagnosis

Elevated LDL Triglycerides and Atherosclerotic Risk.
Balling M, Afzal S, Davey Smith G, Varbo A, Langsted A, Kamstrup PR, Nordestgaard BG
J Am Coll Cardiol 2023 Jan 17;81(2):136-152. doi: 10.1016/j.jacc.2022.10.019. PMID: 36631208
Triglycerides and Residual Atherosclerotic Risk.
Raposeiras-Roubin S, Rosselló X, Oliva B, Fernández-Friera L, Mendiguren JM, Andrés V, Bueno H, Sanz J, Martínez de Vega V, Abu-Assi E, Iñiguez A, Fernández-Ortiz A, Ibáñez B, Fuster V
J Am Coll Cardiol 2021 Jun 22;77(24):3031-3041. doi: 10.1016/j.jacc.2021.04.059. PMID: 34140107Free PMC Article
Dyslipemias and pregnancy, an update.
Mauri M, Calmarza P, Ibarretxe D
Clin Investig Arterioscler 2021 Jan-Feb;33(1):41-52. Epub 2020 Dec 9 doi: 10.1016/j.arteri.2020.10.002. PMID: 33309071
Hypertriglyceridemia triggered acute pancreatitis in pregnancy - diagnostic approach, management and follow-up care.
Cruciat G, Nemeti G, Goidescu I, Anitan S, Florian A
Lipids Health Dis 2020 Jan 4;19(1):2. doi: 10.1186/s12944-019-1180-7. PMID: 31901241Free PMC Article
Hypertriglyceridemia - Common Causes, Prevention and Treatment Strategies.
Rygiel K
Curr Cardiol Rev 2018 Mar 14;14(1):67-76. doi: 10.2174/1573403X14666180123165542. PMID: 29366425Free PMC Article

Therapy

Elevated LDL Triglycerides and Atherosclerotic Risk.
Balling M, Afzal S, Davey Smith G, Varbo A, Langsted A, Kamstrup PR, Nordestgaard BG
J Am Coll Cardiol 2023 Jan 17;81(2):136-152. doi: 10.1016/j.jacc.2022.10.019. PMID: 36631208
Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease.
Duran EK, Pradhan AD
Clin Chem 2021 Jan 8;67(1):183-196. doi: 10.1093/clinchem/hvaa296. PMID: 33409533
Hypertriglyceridemia triggered acute pancreatitis in pregnancy - diagnostic approach, management and follow-up care.
Cruciat G, Nemeti G, Goidescu I, Anitan S, Florian A
Lipids Health Dis 2020 Jan 4;19(1):2. doi: 10.1186/s12944-019-1180-7. PMID: 31901241Free PMC Article
Hypertriglyceridemia - Common Causes, Prevention and Treatment Strategies.
Rygiel K
Curr Cardiol Rev 2018 Mar 14;14(1):67-76. doi: 10.2174/1573403X14666180123165542. PMID: 29366425Free PMC Article
Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study.
Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, Azizi F
Horm Metab Res 2017 Mar;49(3):192-200. Epub 2017 Mar 28 doi: 10.1055/s-0042-117279. PMID: 28351085

Prognosis

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.
Liang YY, Chen J, Peng M, Zhou J, Chen X, Tan X, Wang N, Ma H, Guo L, Zhang J, Wing YK, Geng Q, Ai S
J Transl Med 2023 Feb 7;21(1):90. doi: 10.1186/s12967-023-03920-2. PMID: 36747249Free PMC Article
A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia.
Sampson M, Ling C, Sun Q, Harb R, Ashmaig M, Warnick R, Sethi A, Fleming JK, Otvos JD, Meeusen JW, Delaney SR, Jaffe AS, Shamburek R, Amar M, Remaley AT
JAMA Cardiol 2020 May 1;5(5):540-548. doi: 10.1001/jamacardio.2020.0013. PMID: 32101259Free PMC Article
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators
N Engl J Med 2019 Jan 3;380(1):11-22. Epub 2018 Nov 10 doi: 10.1056/NEJMoa1812792. PMID: 30415628
Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study.
Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, Azizi F
Horm Metab Res 2017 Mar;49(3):192-200. Epub 2017 Mar 28 doi: 10.1055/s-0042-117279. PMID: 28351085
Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology.
Nordestgaard BG
Circ Res 2016 Feb 19;118(4):547-63. doi: 10.1161/CIRCRESAHA.115.306249. PMID: 26892957

Clinical prediction guides

Mechanisms linking hypertriglyceridemia to acute pancreatitis.
Kiss L, Fűr G, Pisipati S, Rajalingamgari P, Ewald N, Singh V, Rakonczay Z Jr
Acta Physiol (Oxf) 2023 Mar;237(3):e13916. Epub 2023 Jan 13 doi: 10.1111/apha.13916. PMID: 36599412
Incidence and clinical characteristics of hypertriglyceridemic acute pancreatitis: A retrospective single-center study.
Lin XY, Zeng Y, Zhang ZC, Lin ZH, Chen LC, Ye ZS
World J Gastroenterol 2022 Aug 7;28(29):3946-3959. doi: 10.3748/wjg.v28.i29.3946. PMID: 36157550Free PMC Article
Triglycerides and Residual Atherosclerotic Risk.
Raposeiras-Roubin S, Rosselló X, Oliva B, Fernández-Friera L, Mendiguren JM, Andrés V, Bueno H, Sanz J, Martínez de Vega V, Abu-Assi E, Iñiguez A, Fernández-Ortiz A, Ibáñez B, Fuster V
J Am Coll Cardiol 2021 Jun 22;77(24):3031-3041. doi: 10.1016/j.jacc.2021.04.059. PMID: 34140107Free PMC Article
Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid Study.
Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, Azizi F
Horm Metab Res 2017 Mar;49(3):192-200. Epub 2017 Mar 28 doi: 10.1055/s-0042-117279. PMID: 28351085
Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology.
Nordestgaard BG
Circ Res 2016 Feb 19;118(4):547-63. doi: 10.1161/CIRCRESAHA.115.306249. PMID: 26892957

Recent systematic reviews

Insulin or blood purification treatment for hypertriglyceridaemia-associated acute pancreatitis: A systematic review and meta-analysis.
He W, Cai W, Yang X, Camilleri G, Zheng X, Wang Q, Li Y, Mukherjee R, Huang W, Sutton R
Pancreatology 2022 Nov;22(7):846-857. Epub 2022 Aug 1 doi: 10.1016/j.pan.2022.07.013. PMID: 35981949
Chia seed (Salvia hispanica L.) consumption and lipid profile: a systematic review and meta-analysis.
Silva LA, Verneque BJF, Mota APL, Duarte CK
Food Funct 2021 Oct 4;12(19):8835-8849. doi: 10.1039/d1fo01287h. PMID: 34378609
Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.
Bálint ER, Fűr G, Kiss L, Németh DI, Soós A, Hegyi P, Szakács Z, Tinusz B, Varjú P, Vincze Á, Erőss B, Czimmer J, Szepes Z, Varga G, Rakonczay Z Jr
Sci Rep 2020 Oct 21;10(1):17936. doi: 10.1038/s41598-020-74943-8. PMID: 33087766Free PMC Article
Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis.
Kotwal A, Cortes T, Genere N, Hamidi O, Jasim S, Newman CB, Prokop LJ, Murad MH, Alahdab F
J Clin Endocrinol Metab 2020 Dec 1;105(12) doi: 10.1210/clinem/dgaa672. PMID: 32954428
Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders--a systematic review and meta-analysis.
Mitchell AJ, Vancampfort D, Sweers K, van Winkel R, Yu W, De Hert M
Schizophr Bull 2013 Mar;39(2):306-18. Epub 2011 Dec 29 doi: 10.1093/schbul/sbr148. PMID: 22207632Free PMC Article

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