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Mesangial fibrillary deposits

MedGen UID:
1787157
Concept ID:
C5539671
Finding
HPO: HP:0033545

Definition

Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesangial fibrillary deposits

Recent clinical studies

Etiology

Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C
J Nephrol 2021 Jun;34(3):883-892. Epub 2020 Jun 18 doi: 10.1007/s40620-020-00783-4. PMID: 32557205
Sethi S, Fervenza FC
Nephrol Dial Transplant 2019 Feb 1;34(2):193-199. doi: 10.1093/ndt/gfy220. PMID: 30124958
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD
Kidney Int 2003 Apr;63(4):1450-61. doi: 10.1046/j.1523-1755.2003.00853.x. PMID: 12631361
Hvala A, Kobenter T, Ferluga D
Wien Klin Wochenschr 2000 Aug 25;112(15-16):711-5. PMID: 11020962
Duffy JL, Khurana E, Susin M, Gomez-Leon G, Churg J
Am J Pathol 1983 Dec;113(3):279-90. PMID: 6359891Free PMC Article

Diagnosis

Hattori K, Shimizu R, Tanaka S, Terashima T, Hiramatsu M, Shimomura T, Ito T, Morinaga T, Terasaki M, Shimizu A, Morozumi K, Tamai H
CEN Case Rep 2022 Nov;11(4):412-416. Epub 2022 Feb 23 doi: 10.1007/s13730-022-00693-3. PMID: 35199316Free PMC Article
Chalkia A, Alexakou Z, Kourniotis D, Mpora M, Gakiopoulou H, Petras D
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1820-1825. doi: 10.4103/1319-2442.352448. PMID: 35946300
Said SM, Rocha AB, Royal V, Valeri AM, Larsen CP, Theis JD, Vrana JA, McPhail ED, Bandi L, Safabakhsh S, Barnes C, Cornell LD, Fidler ME, Alexander MP, Leung N, Nasr SH
Am J Kidney Dis 2021 Mar;77(3):454-458. Epub 2020 Jul 23 doi: 10.1053/j.ajkd.2020.04.015. PMID: 32711071
Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C
J Nephrol 2021 Jun;34(3):883-892. Epub 2020 Jun 18 doi: 10.1007/s40620-020-00783-4. PMID: 32557205
Sethi S, Fervenza FC
Nephrol Dial Transplant 2019 Feb 1;34(2):193-199. doi: 10.1093/ndt/gfy220. PMID: 30124958

Therapy

Chalkia A, Alexakou Z, Kourniotis D, Mpora M, Gakiopoulou H, Petras D
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1820-1825. doi: 10.4103/1319-2442.352448. PMID: 35946300
Said SM, Rocha AB, Royal V, Valeri AM, Larsen CP, Theis JD, Vrana JA, McPhail ED, Bandi L, Safabakhsh S, Barnes C, Cornell LD, Fidler ME, Alexander MP, Leung N, Nasr SH
Am J Kidney Dis 2021 Mar;77(3):454-458. Epub 2020 Jul 23 doi: 10.1053/j.ajkd.2020.04.015. PMID: 32711071
Javaugue V, Karras A, Glowacki F, McGregor B, Lacombe C, Goujon JM, Ragot S, Aucouturier P, Touchard G, Bridoux F
Am J Kidney Dis 2013 Oct;62(4):679-90. Epub 2013 Jun 4 doi: 10.1053/j.ajkd.2013.03.031. PMID: 23759297
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD
Kidney Int 2003 Apr;63(4):1450-61. doi: 10.1046/j.1523-1755.2003.00853.x. PMID: 12631361
Fogo A, Qureshi N, Horn RG
Am J Kidney Dis 1993 Sep;22(3):367-77. doi: 10.1016/s0272-6386(12)70138-5. PMID: 8372831

Prognosis

Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C
J Nephrol 2021 Jun;34(3):883-892. Epub 2020 Jun 18 doi: 10.1007/s40620-020-00783-4. PMID: 32557205
Touzot M, Terrier CS, Faguer S, Masson I, François H, Couzi L, Hummel A, Quellard N, Touchard G, Jourde-Chiche N, Goujon JM, Daugas E; Groupe Coopératif sur le Lupus Rénal (GCLR)
Medicine (Baltimore) 2017 Dec;96(48):e9017. doi: 10.1097/MD.0000000000009017. PMID: 29310419Free PMC Article
Javaugue V, Karras A, Glowacki F, McGregor B, Lacombe C, Goujon JM, Ragot S, Aucouturier P, Touchard G, Bridoux F
Am J Kidney Dis 2013 Oct;62(4):679-90. Epub 2013 Jun 4 doi: 10.1053/j.ajkd.2013.03.031. PMID: 23759297
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD
Kidney Int 2003 Apr;63(4):1450-61. doi: 10.1046/j.1523-1755.2003.00853.x. PMID: 12631361
Fogo A, Qureshi N, Horn RG
Am J Kidney Dis 1993 Sep;22(3):367-77. doi: 10.1016/s0272-6386(12)70138-5. PMID: 8372831

Clinical prediction guides

Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C
J Nephrol 2021 Jun;34(3):883-892. Epub 2020 Jun 18 doi: 10.1007/s40620-020-00783-4. PMID: 32557205
Touzot M, Terrier CS, Faguer S, Masson I, François H, Couzi L, Hummel A, Quellard N, Touchard G, Jourde-Chiche N, Goujon JM, Daugas E; Groupe Coopératif sur le Lupus Rénal (GCLR)
Medicine (Baltimore) 2017 Dec;96(48):e9017. doi: 10.1097/MD.0000000000009017. PMID: 29310419Free PMC Article
Hara S, Tsukaguchi H, Oka T, Kusabe M, Mizui M, Joh K
Ultrastruct Pathol 2017 Jul-Aug;41(4):301-307. Epub 2017 Jun 19 doi: 10.1080/01913123.2017.1336189. PMID: 28628381
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD
Kidney Int 2003 Apr;63(4):1450-61. doi: 10.1046/j.1523-1755.2003.00853.x. PMID: 12631361
Moulin B, Ronco PM, Mougenot B, Francois A, Fillastre JP, Mignon F
Kidney Int 1992 Jul;42(1):127-35. doi: 10.1038/ki.1992.270. PMID: 1635342

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