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Irreversible airflow obstruction

MedGen UID:
1787242
Concept ID:
C5539669
Finding
Synonym: Irreversible pulmonary obstruction
 
HPO: HP:0033541

Definition

Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIrreversible airflow obstruction

Professional guidelines

PubMed

Williamson A, Martineau AR, Jolliffe D, Sheikh A, Janssens W, Sluyter J, Rafiq R, de Jongh R, Griffiths CJ
Cochrane Database Syst Rev 2024 Sep 27;9(9):CD013284. doi: 10.1002/14651858.CD013284.pub2. PMID: 39329240Free PMC Article
Amore E, Manca ML, Ferraro M, Valenti D, La Parola V, Di Vincenzo S, Gjomarkaj M, Giammona G, Bondì ML, Pace E
Int J Pharm 2019 May 1;562:351-358. Epub 2019 Mar 29 doi: 10.1016/j.ijpharm.2019.03.059. PMID: 30935915
Martinez FD
J Allergy Clin Immunol 1999 Oct;104(4 Pt 2):169-74. doi: 10.1016/s0091-6749(99)70058-8. PMID: 10518843

Recent clinical studies

Therapy

Li S, Huang Q, He B
Lung 2023 Apr;201(2):201-215. Epub 2023 Feb 15 doi: 10.1007/s00408-023-00607-9. PMID: 36790647
Varricchi G, Ferri S, Pepys J, Poto R, Spadaro G, Nappi E, Paoletti G, Virchow JC, Heffler E, Canonica WG
Allergy 2022 Dec;77(12):3538-3552. Epub 2022 Aug 23 doi: 10.1111/all.15473. PMID: 35950646Free PMC Article
Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Strek ME
Proc Am Thorac Soc 2006;3(1):116-23. doi: 10.1513/pats.200510-115JH. PMID: 16493159

Prognosis

Tramontano A, Palange P
Nutrients 2023 Apr 6;15(7) doi: 10.3390/nu15071786. PMID: 37049625Free PMC Article
Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Strek ME
Proc Am Thorac Soc 2006;3(1):116-23. doi: 10.1513/pats.200510-115JH. PMID: 16493159
van den Toorn LM, Overbeek SE, Prins JB, Hoogsteden HC, de Jongste JC
Curr Opin Pulm Med 2003 Jan;9(1):15-20. doi: 10.1097/00063198-200301000-00003. PMID: 12476079

Clinical prediction guides

Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Sumi Y, Hamid Q
Allergol Int 2007 Dec;56(4):341-8. Epub 2007 Nov 1 doi: 10.2332/allergolint.R-07-153. PMID: 17965577
Saha S, Brightling CE
Int J Chron Obstruct Pulmon Dis 2006;1(1):39-47. doi: 10.2147/copd.2006.1.1.39. PMID: 18046901Free PMC Article
Fish JE, Peters SP
J Allergy Clin Immunol 1999 Sep;104(3 Pt 1):509-16. doi: 10.1016/s0091-6749(99)70315-5. PMID: 10482819

Recent systematic reviews

Williamson A, Martineau AR, Jolliffe D, Sheikh A, Janssens W, Sluyter J, Rafiq R, de Jongh R, Griffiths CJ
Cochrane Database Syst Rev 2024 Sep 27;9(9):CD013284. doi: 10.1002/14651858.CD013284.pub2. PMID: 39329240Free PMC Article

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