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Neuroinflammatory Diseases

MedGen UID:
1787585
•Concept ID:
C5544451
•
Disease or Syndrome
Synonyms: Disease, Neuroinflammatory; Disorder, Neuroinflammatory; Neuroinflammatory Disease; Neuroinflammatory Disorder; Neuroinflammatory Disorders

Definition

Diseases characterized by inflammation of the nervous tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroinflammatory Diseases

Professional guidelines

PubMed

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease.
Aili M, Zhou K, Zhan J, Zheng H, Luo F
J Mater Chem B 2023 Sep 20;11(36):8605-8621. doi: 10.1039/d3tb01023f. PMID: 37615596
Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.
Menculini G, Chipi E, Paolini Paoletti F, Gaetani L, Nigro P, Simoni S, Mancini A, Tambasco N, Di Filippo M, Tortorella A, Parnetti L
Int J Mol Sci 2021 Apr 23;22(9) doi: 10.3390/ijms22094440. PMID: 33922780Free PMC Article
Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.
Lombardi VC, De Meirleir KL, Subramanian K, Nourani SM, Dagda RK, Delaney SL, Palotás A
J Nutr Biochem 2018 Nov;61:1-16. Epub 2018 Apr 19 doi: 10.1016/j.jnutbio.2018.04.004. PMID: 29886183Free PMC Article

Recent clinical studies

Etiology

APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease.
Parhizkar S, Holtzman DM
Semin Immunol 2022 Jan;59:101594. Epub 2022 Feb 26 doi: 10.1016/j.smim.2022.101594. PMID: 35232622Free PMC Article
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K
Gut 2022 Nov;71(11):2233-2252. Epub 2022 Jan 11 doi: 10.1136/gutjnl-2021-326269. PMID: 35017199
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies.
Jurcau A, Simion A
Int J Mol Sci 2021 Dec 21;23(1) doi: 10.3390/ijms23010014. PMID: 35008440Free PMC Article
Maternal immune activation and neuroinflammation in human neurodevelopmental disorders.
Han VX, Patel S, Jones HF, Dale RC
Nat Rev Neurol 2021 Sep;17(9):564-579. Epub 2021 Aug 2 doi: 10.1038/s41582-021-00530-8. PMID: 34341569
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676

Diagnosis

Biomarker of Neuroinflammation in Parkinson's Disease.
Liu TW, Chen CM, Chang KH
Int J Mol Sci 2022 Apr 8;23(8) doi: 10.3390/ijms23084148. PMID: 35456966Free PMC Article
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.
Candelario-Jalil E, Dijkhuizen RM, Magnus T
Stroke 2022 May;53(5):1473-1486. Epub 2022 Apr 7 doi: 10.1161/STROKEAHA.122.036946. PMID: 35387495Free PMC Article
Toward noninvasive brain stimulation 2.0 in Alzheimer's disease.
Menardi A, Rossi S, Koch G, Hampel H, Vergallo A, Nitsche MA, Stern Y, Borroni B, Cappa SF, Cotelli M, Ruffini G, El-Fakhri G, Rossini PM, Dickerson B, Antal A, Babiloni C, Lefaucheur JP, Dubois B, Deco G, Ziemann U, Pascual-Leone A, Santarnecchi E
Ageing Res Rev 2022 Mar;75:101555. Epub 2021 Dec 30 doi: 10.1016/j.arr.2021.101555. PMID: 34973457Free PMC Article
PET Imaging of Neuroinflammation in Alzheimer's Disease.
Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R
Front Immunol 2021;12:739130. Epub 2021 Sep 16 doi: 10.3389/fimmu.2021.739130. PMID: 34603323Free PMC Article
Immunoneuropsychiatry - novel perspectives on brain disorders.
Pape K, Tamouza R, Leboyer M, Zipp F
Nat Rev Neurol 2019 Jun;15(6):317-328. doi: 10.1038/s41582-019-0174-4. PMID: 30988501

Therapy

Beneficial effects of natural flavonoids on neuroinflammation.
Chen Y, Peng F, Xing Z, Chen J, Peng C, Li D
Front Immunol 2022;13:1006434. Epub 2022 Oct 24 doi: 10.3389/fimmu.2022.1006434. PMID: 36353622Free PMC Article
The role of the gut microbiota in multiple sclerosis.
Correale J, Hohlfeld R, Baranzini SE
Nat Rev Neurol 2022 Sep;18(9):544-558. Epub 2022 Aug 5 doi: 10.1038/s41582-022-00697-8. PMID: 35931825
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases.
Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladâcenco O, Roza E, Costăchescu B, Grumezescu AM, Teleanu RI
Int J Mol Sci 2022 May 25;23(11) doi: 10.3390/ijms23115938. PMID: 35682615Free PMC Article
NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Hou Y, Wei Y, Lautrup S, Yang B, Wang Y, Cordonnier S, Mattson MP, Croteau DL, Bohr VA
Proc Natl Acad Sci U S A 2021 Sep 14;118(37) doi: 10.1073/pnas.2011226118. PMID: 34497121Free PMC Article
Early glycolytic reprogramming controls microglial inflammatory activation.
Cheng J, Zhang R, Xu Z, Ke Y, Sun R, Yang H, Zhang X, Zhen X, Zheng LT
J Neuroinflammation 2021 Jun 9;18(1):129. doi: 10.1186/s12974-021-02187-y. PMID: 34107997Free PMC Article

Prognosis

Adult-Onset Genetic Central Nervous System Disorders Masquerading as Acquired Neuroinflammatory Disorders: A Review.
Ayrignac X, Carra-Dallière C, Marelli C, Taïeb G, Labauge P
JAMA Neurol 2022 Oct 1;79(10):1069-1078. doi: 10.1001/jamaneurol.2022.2141. PMID: 35969413
The role of the gut microbiota in multiple sclerosis.
Correale J, Hohlfeld R, Baranzini SE
Nat Rev Neurol 2022 Sep;18(9):544-558. Epub 2022 Aug 5 doi: 10.1038/s41582-022-00697-8. PMID: 35931825
Toward noninvasive brain stimulation 2.0 in Alzheimer's disease.
Menardi A, Rossi S, Koch G, Hampel H, Vergallo A, Nitsche MA, Stern Y, Borroni B, Cappa SF, Cotelli M, Ruffini G, El-Fakhri G, Rossini PM, Dickerson B, Antal A, Babiloni C, Lefaucheur JP, Dubois B, Deco G, Ziemann U, Pascual-Leone A, Santarnecchi E
Ageing Res Rev 2022 Mar;75:101555. Epub 2021 Dec 30 doi: 10.1016/j.arr.2021.101555. PMID: 34973457Free PMC Article
Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade.
Przykaza Ł
Front Immunol 2021;12:782569. Epub 2021 Nov 15 doi: 10.3389/fimmu.2021.782569. PMID: 34868060Free PMC Article
PET Imaging of Neuroinflammation in Alzheimer's Disease.
Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R
Front Immunol 2021;12:739130. Epub 2021 Sep 16 doi: 10.3389/fimmu.2021.739130. PMID: 34603323Free PMC Article

Clinical prediction guides

PET Imaging of Neuroinflammation in Alzheimer's Disease.
Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R
Front Immunol 2021;12:739130. Epub 2021 Sep 16 doi: 10.3389/fimmu.2021.739130. PMID: 34603323Free PMC Article
NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Hou Y, Wei Y, Lautrup S, Yang B, Wang Y, Cordonnier S, Mattson MP, Croteau DL, Bohr VA
Proc Natl Acad Sci U S A 2021 Sep 14;118(37) doi: 10.1073/pnas.2011226118. PMID: 34497121Free PMC Article
MCP-1: Function, regulation, and involvement in disease.
Singh S, Anshita D, Ravichandiran V
Int Immunopharmacol 2021 Dec;101(Pt B):107598. Epub 2021 May 20 doi: 10.1016/j.intimp.2021.107598. PMID: 34233864Free PMC Article
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676
Cytokine networks in neuroinflammation.
Becher B, Spath S, Goverman J
Nat Rev Immunol 2017 Jan;17(1):49-59. Epub 2016 Dec 5 doi: 10.1038/nri.2016.123. PMID: 27916979

Recent systematic reviews

The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation.
Xin Y, Tian M, Deng S, Li J, Yang M, Gao J, Pei X, Wang Y, Tan J, Zhao F, Gao Y, Gong Y
Mol Neurobiol 2023 Mar;60(3):1369-1390. Epub 2022 Nov 29 doi: 10.1007/s12035-022-03148-z. PMID: 36445634Free PMC Article
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury.
Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, Mei Z, Wang G, Ge J
Front Immunol 2022;13:930171. Epub 2022 Oct 7 doi: 10.3389/fimmu.2022.930171. PMID: 36275741Free PMC Article
Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis.
Ineichen BV, Tsagkas C, Absinta M, Reich DS
Neuroimage Clin 2022;33:102939. Epub 2022 Jan 10 doi: 10.1016/j.nicl.2022.102939. PMID: 35026625Free PMC Article
Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies.
Zamani R, Pouremamali R, Rezaei N
Rev Neurosci 2022 Jun 27;33(4):397-412. Epub 2021 Sep 17 doi: 10.1515/revneuro-2021-0082. PMID: 34536341
The Amyloid-β Pathway in Alzheimer's Disease.
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A
Mol Psychiatry 2021 Oct;26(10):5481-5503. Epub 2021 Aug 30 doi: 10.1038/s41380-021-01249-0. PMID: 34456336Free PMC Article

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