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Locally Recurrent Anal Canal Squamous Cell Carcinoma

MedGen UID:
1787609
•Concept ID:
C5446471
•
Neoplastic Process

Definition

The reemergence of anal canal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Recurrent Anal Canal Squamous Cell Carcinoma

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
Experimental and investigational drugs for the treatment of anal cancer.
Jacome AA, Eng C
Expert Opin Investig Drugs 2018 Dec;27(12):941-950. Epub 2018 Nov 8 doi: 10.1080/13543784.2018.1543659. PMID: 30381968
Treatment of the Primary Tumor in Anal Canal Cancers.
Glynne-Jones R, Rao S
Surg Oncol Clin N Am 2017 Jan;26(1):73-90. doi: 10.1016/j.soc.2016.07.003. PMID: 27889038

Recent clinical studies

Etiology

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Locally Recurrent Disease Related to Anal Canal Cancers.
Sammour T, Rodriguez-Bigas MA, Skibber JM
Surg Oncol Clin N Am 2017 Jan;26(1):115-125. doi: 10.1016/j.soc.2016.07.006. PMID: 27889030

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Experimental and investigational drugs for the treatment of anal cancer.
Jacome AA, Eng C
Expert Opin Investig Drugs 2018 Dec;27(12):941-950. Epub 2018 Nov 8 doi: 10.1080/13543784.2018.1543659. PMID: 30381968
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Anal squamous cell carcinoma: are we improving outcomes?
Mackowski A, Levitt M, Makin G, Salama P, Tan P, Penter C, Platell C
ANZ J Surg 2018 Oct;88(10):1013-1016. Epub 2018 Aug 29 doi: 10.1111/ans.14745. PMID: 30159994
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Anal squamous cell carcinoma: are we improving outcomes?
Mackowski A, Levitt M, Makin G, Salama P, Tan P, Penter C, Platell C
ANZ J Surg 2018 Oct;88(10):1013-1016. Epub 2018 Aug 29 doi: 10.1111/ans.14745. PMID: 30159994
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma.
Mouw KW, Cleary JM, Reardon B, Pike J, Braunstein LZ, Kim J, Amin-Mansour A, Miao D, Damish A, Chin J, Ott PA, Fuchs CS, Martin NE, Getz G, Carter S, Mamon HJ, Hornick JL, Van Allen EM, D'Andrea AD
Clin Cancer Res 2017 Jun 15;23(12):3214-3222. Epub 2016 Nov 16 doi: 10.1158/1078-0432.CCR-16-2017. PMID: 27852700Free PMC Article

Recent systematic reviews

Outcome following local excision of T1 anal cancers-a systematic review.
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458

Supplemental Content

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