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Elevated circulating amyloid A concentration

MedGen UID:
1788190
Concept ID:
C5539521
Finding
Synonym: Elevated circulating amyloid A
 
HPO: HP:0033332

Definition

The concentration of serum amyloid A in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating amyloid A concentration

Conditions with this feature

Familial Mediterranean fever
MedGen UID:
45811
Concept ID:
C0031069
Disease or Syndrome
Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to renal failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.
Immunodeficiency 94 with autoinflammation and dysmorphic facies
MedGen UID:
1802872
Concept ID:
C5676918
Disease or Syndrome
Immunodeficiency-94 with autoinflammation and dysmorphic facies (IMD94) is a systemic immunologic disorder with onset in early infancy. Primary features include lymphadenopathy, autoinflammation, immunodeficiency with hypogammaglobulinemia, and dysmorphic facial features. Intellectual development is normal and serum IgE is not elevated. The disease results from constitutive activation of the IL6 signaling cascade, resulting in immune dysregulation and a hyperinflammatory state (summary by Materna-Kiryluk et al., 2021).

Recent clinical studies

Etiology

Stenberg K, Gensby L, Cremer SE, Nielsen MM, Bjørnvad CR
Acta Vet Scand 2022 Sep 5;64(1):22. doi: 10.1186/s13028-022-00640-3. PMID: 36064726Free PMC Article
Menschikowski M, Hagelgans A, Fuessel S, Mareninova OA, Asatryan L, Wirth MP, Siegert G
Inflamm Res 2013 Dec;62(12):1063-72. Epub 2013 Sep 24 doi: 10.1007/s00011-013-0665-5. PMID: 24061501
Gómez-Ambrosi J, Azcona C, Patiño-García A, Frühbeck G
J Pediatr 2008 Jul;153(1):71-5. Epub 2008 Mar 7 doi: 10.1016/j.jpeds.2008.01.006. PMID: 18571540
Smith CC, Betteridge DJ
Neurosci Lett 2004 Aug 26;367(1):48-50. doi: 10.1016/j.neulet.2004.05.081. PMID: 15308295
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V
Atherosclerosis 2000 Feb;148(2):209-14. doi: 10.1016/s0021-9150(99)00463-3. PMID: 10657556

Diagnosis

Stenberg K, Gensby L, Cremer SE, Nielsen MM, Bjørnvad CR
Acta Vet Scand 2022 Sep 5;64(1):22. doi: 10.1186/s13028-022-00640-3. PMID: 36064726Free PMC Article
Uhde M, Ajamian M, Li X, Wormser GP, Marques A, Alaedini A
Clin Infect Dis 2016 Dec 1;63(11):1399-1404. Epub 2016 Sep 1 doi: 10.1093/cid/ciw599. PMID: 27585799Free PMC Article
Mengus C, Le Magnen C, Trella E, Yousef K, Bubendorf L, Provenzano M, Bachmann A, Heberer M, Spagnoli GC, Wyler S
J Transl Med 2011 Sep 26;9:162. doi: 10.1186/1479-5876-9-162. PMID: 21943235Free PMC Article
Biasucci LM, Liuzzo G, Angiolillo DJ, Sperti G, Maseri A
Herz 2000 Mar;25(2):108-12. doi: 10.1007/pl00001947. PMID: 10829249
Benson MD, Eyanson S, Fineberg NS
Cancer 1986 May 1;57(9):1783-7. doi: 10.1002/1097-0142(19860501)57:9<1783::aid-cncr2820570912>3.0.co;2-l. PMID: 3006907

Therapy

Pace A, Villamediana P, Rezamand P, Skibiel AL
J Anim Sci 2023 Jan 3;101 doi: 10.1093/jas/skad246. PMID: 37465977Free PMC Article
Uhde M, Ajamian M, Li X, Wormser GP, Marques A, Alaedini A
Clin Infect Dis 2016 Dec 1;63(11):1399-1404. Epub 2016 Sep 1 doi: 10.1093/cid/ciw599. PMID: 27585799Free PMC Article
Villaseñor A, Ambs A, Ballard-Barbash R, Baumgartner KB, McTiernan A, Ulrich CM, Neuhouser ML
Breast Cancer Res Treat 2011 Sep;129(2):485-94. Epub 2011 Apr 1 doi: 10.1007/s10549-011-1474-6. PMID: 21455669Free PMC Article
Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P
Circulation 2004 Feb 24;109(7):849-54. Epub 2004 Feb 2 doi: 10.1161/01.CIR.0000116762.77804.FC. PMID: 14757687
Biasucci LM, Liuzzo G, Angiolillo DJ, Sperti G, Maseri A
Herz 2000 Mar;25(2):108-12. doi: 10.1007/pl00001947. PMID: 10829249

Prognosis

Menschikowski M, Hagelgans A, Fuessel S, Mareninova OA, Asatryan L, Wirth MP, Siegert G
Inflamm Res 2013 Dec;62(12):1063-72. Epub 2013 Sep 24 doi: 10.1007/s00011-013-0665-5. PMID: 24061501
Gómez-Ambrosi J, Azcona C, Patiño-García A, Frühbeck G
J Pediatr 2008 Jul;153(1):71-5. Epub 2008 Mar 7 doi: 10.1016/j.jpeds.2008.01.006. PMID: 18571540
Biasucci LM, Liuzzo G, Angiolillo DJ, Sperti G, Maseri A
Herz 2000 Mar;25(2):108-12. doi: 10.1007/pl00001947. PMID: 10829249
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V
Atherosclerosis 2000 Feb;148(2):209-14. doi: 10.1016/s0021-9150(99)00463-3. PMID: 10657556
Benson MD, Eyanson S, Fineberg NS
Cancer 1986 May 1;57(9):1783-7. doi: 10.1002/1097-0142(19860501)57:9<1783::aid-cncr2820570912>3.0.co;2-l. PMID: 3006907

Clinical prediction guides

Menschikowski M, Hagelgans A, Fuessel S, Mareninova OA, Asatryan L, Wirth MP, Siegert G
Inflamm Res 2013 Dec;62(12):1063-72. Epub 2013 Sep 24 doi: 10.1007/s00011-013-0665-5. PMID: 24061501
Gómez-Ambrosi J, Azcona C, Patiño-García A, Frühbeck G
J Pediatr 2008 Jul;153(1):71-5. Epub 2008 Mar 7 doi: 10.1016/j.jpeds.2008.01.006. PMID: 18571540
Smith CC, Betteridge DJ
Neurosci Lett 2004 Aug 26;367(1):48-50. doi: 10.1016/j.neulet.2004.05.081. PMID: 15308295
Biasucci LM, Liuzzo G, Angiolillo DJ, Sperti G, Maseri A
Herz 2000 Mar;25(2):108-12. doi: 10.1007/pl00001947. PMID: 10829249
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V
Atherosclerosis 2000 Feb;148(2):209-14. doi: 10.1016/s0021-9150(99)00463-3. PMID: 10657556

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