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Cellular crescent

MedGen UID:
1788506
•Concept ID:
C5539510
•
Finding
HPO: HP:0033317

Definition

A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular crescent

Professional guidelines

PubMed

Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis.
Ikezumi Y, Kondoh T, Matsumoto Y, Kumagai N, Kaneko M, Hasegawa H, Yamada T, Kaneko U, Nikolic-Paterson DJ
Pediatr Nephrol 2021 Feb;36(2):349-359. Epub 2020 Sep 1 doi: 10.1007/s00467-020-04734-w. PMID: 32870362

Recent clinical studies

Etiology

Correlation of Red Blood Cell Casts With Renal Dysfunction in Patients With Infection-Related Glomerulonephritis.
Kitamura M, Biederman L, Ibrahim D, Nadasdy T, Brodsky SV, Satoskar AA
Arch Pathol Lab Med 2024 May 1;148(5):545-552. doi: 10.5858/arpa.2022-0514-OA. PMID: 37622459
Relationship between Renal Damage and Serum Complement C3 in Children with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zhang P, Yang X, He X, Hu J, Gao CL, Xia ZK
Nephron 2021;145(6):633-641. Epub 2021 Jul 1 doi: 10.1159/000516533. PMID: 34198299
Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis.
Ikezumi Y, Kondoh T, Matsumoto Y, Kumagai N, Kaneko M, Hasegawa H, Yamada T, Kaneko U, Nikolic-Paterson DJ
Pediatr Nephrol 2021 Feb;36(2):349-359. Epub 2020 Sep 1 doi: 10.1007/s00467-020-04734-w. PMID: 32870362
ANCA-associated vasculitis with renal involvement.
Binda V, Moroni G, Messa P
J Nephrol 2018 Apr;31(2):197-208. Epub 2017 May 30 doi: 10.1007/s40620-017-0412-z. PMID: 28560688
Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Zeng Y, Wang X, Xie F, Zheng Z
Pathol Res Pract 2017 Aug;213(8):982-986. Epub 2017 Apr 20 doi: 10.1016/j.prp.2017.04.006. PMID: 28595914

Diagnosis

Correlation of Red Blood Cell Casts With Renal Dysfunction in Patients With Infection-Related Glomerulonephritis.
Kitamura M, Biederman L, Ibrahim D, Nadasdy T, Brodsky SV, Satoskar AA
Arch Pathol Lab Med 2024 May 1;148(5):545-552. doi: 10.5858/arpa.2022-0514-OA. PMID: 37622459
Rapidly progressive glomerulonephritis in a patient with angioimmunoblastic T-cell lymphoma: a rare autopsy case showing IgA vasculitis and cylinder-like deposits.
Watanabe H, Fujishima F, Inokura K, Makino R, Daikoku K, Sasaki R, Ichinohasama R, Sato H, Joh K, Sasano H
Med Mol Morphol 2022 Sep;55(3):267-273. Epub 2022 Jun 3 doi: 10.1007/s00795-022-00325-w. PMID: 35657412
Revised ISN/RPS 2018 classification of lupus renal pathology predict clinical remission.
Krassanairawiwong K, Charoenpitakchai M, Supasyndh O, Satirapoj B
Int Urol Nephrol 2021 Jul;53(7):1391-1398. Epub 2021 Mar 8 doi: 10.1007/s11255-020-02732-3. PMID: 33682052
Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report.
Maroz N, Field H
J Med Case Rep 2015 Dec 14;9:282. doi: 10.1186/s13256-015-0764-8. PMID: 26651490Free PMC Article
A case of IgA nephropathy and renal hemosiderosis associated with primary hemochromatosis.
Nakayama M, Kaizu Y, Uesugi N, Nakashita S, Suehiro T
Ren Fail 2008;30(8):813-7. doi: 10.1080/08860220802249033. PMID: 18791957

Therapy

A Kidney Transplant Recipient with Recurrent Henoch-Schönlein Purpura Nephritis Successfully Treated with Steroid Pulse Therapy and Epipharyngeal Abrasive Therapy.
Fujimoto M, Katayama K, Nishikawa K, Mizoguchi S, Oda K, Hirabayashi Y, Suzuki Y, Haruki A, Ito T, Murata T, Ishikawa E, Sugimura Y, Ito M
Nephron 2020;144 Suppl 1:54-58. Epub 2020 Nov 20 doi: 10.1159/000511166. PMID: 33221802
Therapeutic Mechanism of Glucocorticoids on Cellular Crescent Formation in Patients With Antiglomerular Basement Membrane Disease.
Wu X, Zhang M, Huang X, Zhang L, Zeng C, Zhang J, Liu Z, Tang Z
Am J Med Sci 2017 Aug;354(2):145-151. Epub 2017 Apr 25 doi: 10.1016/j.amjms.2017.04.015. PMID: 28864372
Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report.
Maroz N, Field H
J Med Case Rep 2015 Dec 14;9:282. doi: 10.1186/s13256-015-0764-8. PMID: 26651490Free PMC Article
Myeloperoxidase anti-cytoplasmic antibody related crescentic glomerulonephritis in a patient with IgG3λ monoclonal immunoglobulin deposition disease with membranous features.
Ito A, Miura N, Kimura Y, Maeda S, Suzuki K, Kitagawa W, Morita H, Banno S, Imai H
Intern Med 2012;51(17):2393-7. Epub 2012 Sep 1 doi: 10.2169/internalmedicine.51.7900. PMID: 22975555
Plasma exchange combined with immunosuppressive treatment in a child with rapidly progressive IgA nephropathy.
Fujinaga S, Ohtomo Y, Umino D, Mochizuki H, Murakami H, Shimizu T, Yamashiro Y, Kaneko K
Pediatr Nephrol 2007 Jun;22(6):899-902. Epub 2007 Feb 7 doi: 10.1007/s00467-006-0428-4. PMID: 17285293

Prognosis

Revised ISN/RPS 2018 classification of lupus renal pathology predict clinical remission.
Krassanairawiwong K, Charoenpitakchai M, Supasyndh O, Satirapoj B
Int Urol Nephrol 2021 Jul;53(7):1391-1398. Epub 2021 Mar 8 doi: 10.1007/s11255-020-02732-3. PMID: 33682052
ANCA-associated vasculitis with renal involvement.
Binda V, Moroni G, Messa P
J Nephrol 2018 Apr;31(2):197-208. Epub 2017 May 30 doi: 10.1007/s40620-017-0412-z. PMID: 28560688
The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn's disease.
Terasaka T, Uchida HA, Umebayashi R, Tsukamoto K, Tanaka K, Kitagawa M, Sugiyama H, Tanioka H, Wada J
BMC Nephrol 2016 Sep 5;17(1):122. doi: 10.1186/s12882-016-0344-1. PMID: 27596164Free PMC Article
A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss.
Yamashita H, Takahashi Y, Kaneko H, Kano T, Mimori A
Intern Med 2014;53(7):801-4. Epub 2012 Mar 1 doi: 10.2169/internalmedicine.53.1599. PMID: 24694501
Plasma exchange combined with immunosuppressive treatment in a child with rapidly progressive IgA nephropathy.
Fujinaga S, Ohtomo Y, Umino D, Mochizuki H, Murakami H, Shimizu T, Yamashiro Y, Kaneko K
Pediatr Nephrol 2007 Jun;22(6):899-902. Epub 2007 Feb 7 doi: 10.1007/s00467-006-0428-4. PMID: 17285293

Clinical prediction guides

Rapidly progressive glomerulonephritis in a patient with angioimmunoblastic T-cell lymphoma: a rare autopsy case showing IgA vasculitis and cylinder-like deposits.
Watanabe H, Fujishima F, Inokura K, Makino R, Daikoku K, Sasaki R, Ichinohasama R, Sato H, Joh K, Sasano H
Med Mol Morphol 2022 Sep;55(3):267-273. Epub 2022 Jun 3 doi: 10.1007/s00795-022-00325-w. PMID: 35657412
Revised ISN/RPS 2018 classification of lupus renal pathology predict clinical remission.
Krassanairawiwong K, Charoenpitakchai M, Supasyndh O, Satirapoj B
Int Urol Nephrol 2021 Jul;53(7):1391-1398. Epub 2021 Mar 8 doi: 10.1007/s11255-020-02732-3. PMID: 33682052
ANCA-associated vasculitis with renal involvement.
Binda V, Moroni G, Messa P
J Nephrol 2018 Apr;31(2):197-208. Epub 2017 May 30 doi: 10.1007/s40620-017-0412-z. PMID: 28560688
Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Zeng Y, Wang X, Xie F, Zheng Z
Pathol Res Pract 2017 Aug;213(8):982-986. Epub 2017 Apr 20 doi: 10.1016/j.prp.2017.04.006. PMID: 28595914
A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss.
Yamashita H, Takahashi Y, Kaneko H, Kano T, Mimori A
Intern Med 2014;53(7):801-4. Epub 2012 Mar 1 doi: 10.2169/internalmedicine.53.1599. PMID: 24694501

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