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Aortic valve leaflet calcification

MedGen UID:
1788751
•Concept ID:
C5539738
•
Pathologic Function
Synonyms: Aortic cusp calcification; Aortic valve cusp calcification
 
HPO: HP:0033641

Definition

Deposition of calcium salts in the leaflets (cusps) of the aortic valve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAortic valve leaflet calcification

Professional guidelines

PubMed

Calcific aortic valve disease: mechanisms, prevention and treatment.
Moncla LM, Briend M, Bossé Y, Mathieu P
Nat Rev Cardiol 2023 Aug;20(8):546-559. Epub 2023 Feb 24 doi: 10.1038/s41569-023-00845-7. PMID: 36829083
Current Evidence and Future Perspectives on Pharmacological Treatment of Calcific Aortic Valve Stenosis.
Donato M, Ferri N, Lupo MG, Faggin E, Rattazzi M
Int J Mol Sci 2020 Nov 4;21(21) doi: 10.3390/ijms21218263. PMID: 33158204Free PMC Article
Comprehensive Nursing Management for Valvular Disease.
Lee S
Crit Care Nurs Clin North Am 2019 Mar;31(1):31-38. Epub 2018 Dec 22 doi: 10.1016/j.cnc.2018.11.002. PMID: 30736933

Recent clinical studies

Etiology

Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA
J Am Coll Cardiol 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034. PMID: 33032735
Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.
Minami K, Yoneyama K, Izumo M, Suzuki K, Ogawa Y, Chikaraishi K, Ogawa Y, Kobayashi Y, Furukawa T, Tanabe Y, Akashi YJ
J Cardiovasc Comput Tomogr 2016 Nov-Dec;10(6):485-490. Epub 2016 Aug 23 doi: 10.1016/j.jcct.2016.08.006. PMID: 27597530
ox-LDL induces PiT-1 expression in human aortic valve interstitial cells.
Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA
J Surg Res 2013 Sep;184(1):6-9. Epub 2013 May 25 doi: 10.1016/j.jss.2013.05.001. PMID: 23849774Free PMC Article
Correlation between calcific aortic stenosis diagnosed by two-dimensional echocardiography and cardiac catheterization.
Nair CK, Aronow WS, Sketch MH, Mohiuddin SM, Stokke K, Ryschon K
Clin Cardiol 1984 May;7(5):280-2. doi: 10.1002/clc.4960070505. PMID: 6713747

Diagnosis

Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA
J Am Coll Cardiol 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034. PMID: 33032735
Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.
Minami K, Yoneyama K, Izumo M, Suzuki K, Ogawa Y, Chikaraishi K, Ogawa Y, Kobayashi Y, Furukawa T, Tanabe Y, Akashi YJ
J Cardiovasc Comput Tomogr 2016 Nov-Dec;10(6):485-490. Epub 2016 Aug 23 doi: 10.1016/j.jcct.2016.08.006. PMID: 27597530
Correlation between calcific aortic stenosis diagnosed by two-dimensional echocardiography and cardiac catheterization.
Nair CK, Aronow WS, Sketch MH, Mohiuddin SM, Stokke K, Ryschon K
Clin Cardiol 1984 May;7(5):280-2. doi: 10.1002/clc.4960070505. PMID: 6713747

Therapy

Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA
J Am Coll Cardiol 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034. PMID: 33032735

Prognosis

Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA
J Am Coll Cardiol 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034. PMID: 33032735
Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.
Minami K, Yoneyama K, Izumo M, Suzuki K, Ogawa Y, Chikaraishi K, Ogawa Y, Kobayashi Y, Furukawa T, Tanabe Y, Akashi YJ
J Cardiovasc Comput Tomogr 2016 Nov-Dec;10(6):485-490. Epub 2016 Aug 23 doi: 10.1016/j.jcct.2016.08.006. PMID: 27597530

Clinical prediction guides

Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes.
Zhang B, Salaun E, Côté N, Wu Y, Mahjoub H, Mathieu P, Dahou A, Zenses AS, Clisson M, Pibarot P, Clavel MA
J Am Coll Cardiol 2020 Oct 13;76(15):1737-1748. doi: 10.1016/j.jacc.2020.08.034. PMID: 33032735
Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.
Minami K, Yoneyama K, Izumo M, Suzuki K, Ogawa Y, Chikaraishi K, Ogawa Y, Kobayashi Y, Furukawa T, Tanabe Y, Akashi YJ
J Cardiovasc Comput Tomogr 2016 Nov-Dec;10(6):485-490. Epub 2016 Aug 23 doi: 10.1016/j.jcct.2016.08.006. PMID: 27597530

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