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Leukocyte migration defect

MedGen UID:
1788791
•Concept ID:
C5539816
•
Finding
Synonyms: Abnormal leukocyte migration; Defects of leukocyte migration
 
HPO: HP:0033797

Definition

Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukocyte migration defect

Professional guidelines

PubMed

Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies.
Tsinti G, Makris D, Germenis AE, Speletas M
J Immunol Res 2020;2020:8317671. Epub 2020 Nov 20 doi: 10.1155/2020/8317671. PMID: 33274244Free PMC Article
The mechanistic impact of CD22 engagement with epratuzumab on B cell function: Implications for the treatment of systemic lupus erythematosus.
Dörner T, Shock A, Goldenberg DM, Lipsky PE
Autoimmun Rev 2015 Dec;14(12):1079-86. Epub 2015 Jul 23 doi: 10.1016/j.autrev.2015.07.013. PMID: 26212727
Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome.
Xu J, Wang D, Liu D, Fan Z, Zhang H, Liu O, Ding G, Gao R, Zhang C, Ding Y, Bromberg JS, Chen W, Sun L, Wang S
Blood 2012 Oct 11;120(15):3142-51. Epub 2012 Aug 27 doi: 10.1182/blood-2011-11-391144. PMID: 22927248Free PMC Article

Recent clinical studies

Etiology

Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
Quin C, DeJong EN, Cook EK, Luo YZ, Vlasschaert C, Sadh S, McNaughton AJ, Buttigieg MM, Breznik JA, Kennedy AE, Zhao K, Mewburn J, Dunham-Snary KJ, Hindmarch CC, Bick AG, Archer SL, Rauh MJ, Bowdish DM
J Clin Invest 2024 Apr 4;134(11) doi: 10.1172/JCI171002. PMID: 38573824Free PMC Article
Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Crohn's disease.
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Diagnosis

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.
Vu LT, Ahmed F, Zhu H, Iu DSH, Fogarty EA, Kwak Y, Chen W, Franconi CJ, Munn PR, Tate AE, Levine SM, Stevens J, Mao X, Shungu DC, Moore GE, Keller BA, Hanson MR, Grenier JK, Grimson A
Cell Rep Med 2024 Jan 16;5(1):101373. doi: 10.1016/j.xcrm.2023.101373. PMID: 38232699Free PMC Article
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Leukocyte adhesion deficiencies.
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
Crohn's disease.
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Therapy

Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Vitiligo Pathogenesis and Emerging Treatments.
Rashighi M, Harris JE
Dermatol Clin 2017 Apr;35(2):257-265. doi: 10.1016/j.det.2016.11.014. PMID: 28317534Free PMC Article
Dopamine, T cells and multiple sclerosis (MS).
Levite M, Marino F, Cosentino M
J Neural Transm (Vienna) 2017 May;124(5):525-542. Epub 2017 Mar 10 doi: 10.1007/s00702-016-1640-4. PMID: 28283756
Immunosenescence of ageing.
Gruver AL, Hudson LL, Sempowski GD
J Pathol 2007 Jan;211(2):144-56. doi: 10.1002/path.2104. PMID: 17200946Free PMC Article
Chronic mucocutaneous candidiasis.
Kirkpatrick CH
J Am Acad Dermatol 1994 Sep;31(3 Pt 2):S14-7. doi: 10.1016/s0190-9622(08)81260-1. PMID: 8077500

Prognosis

Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy.
Yang Y, Qin S, Yang M, Wang T, Feng R, Zhang C, Zheng E, Li Q, Xiang P, Ning S, Xu X, Zuo X, Zhang S, Yun X, Zhou X, Wang Y, He L, Shang Y, Sun L, Liu H
Clin Cancer Res 2024 Sep 13;30(18):4201-4214. doi: 10.1158/1078-0432.CCR-24-0352. PMID: 39024031Free PMC Article
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Leukocyte adhesion deficiencies.
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
The neutrophil.
Haslett C, Savill JS, Meagher L
Curr Opin Immunol 1989 Oct;2(1):10-8. doi: 10.1016/0952-7915(89)90091-5. PMID: 2514726

Clinical prediction guides

Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy.
Yang Y, Qin S, Yang M, Wang T, Feng R, Zhang C, Zheng E, Li Q, Xiang P, Ning S, Xu X, Zuo X, Zhang S, Yun X, Zhou X, Wang Y, He L, Shang Y, Sun L, Liu H
Clin Cancer Res 2024 Sep 13;30(18):4201-4214. doi: 10.1158/1078-0432.CCR-24-0352. PMID: 39024031Free PMC Article
Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges.
Indini A, Massi D, Pirro M, Roila F, Grossi F, Sahebkar A, Glodde N, Bald T, Mandalà M
Semin Cancer Biol 2022 Nov;86(Pt 2):477-490. Epub 2022 Jun 22 doi: 10.1016/j.semcancer.2022.06.005. PMID: 35752398
The neutrophil.
Haslett C, Savill JS, Meagher L
Curr Opin Immunol 1989 Oct;2(1):10-8. doi: 10.1016/0952-7915(89)90091-5. PMID: 2514726

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