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Leukocyte migration defect

MedGen UID:
1788791
Concept ID:
C5539816
Finding
Synonyms: Abnormal leukocyte migration; Defects of leukocyte migration
 
HPO: HP:0033797

Definition

Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukocyte migration defect

Professional guidelines

PubMed

Tsinti G, Makris D, Germenis AE, Speletas M
J Immunol Res 2020;2020:8317671. Epub 2020 Nov 20 doi: 10.1155/2020/8317671. PMID: 33274244Free PMC Article
Xu J, Wang D, Liu D, Fan Z, Zhang H, Liu O, Ding G, Gao R, Zhang C, Ding Y, Bromberg JS, Chen W, Sun L, Wang S
Blood 2012 Oct 11;120(15):3142-51. Epub 2012 Aug 27 doi: 10.1182/blood-2011-11-391144. PMID: 22927248Free PMC Article
Fitzhugh DJ, Shan S, Dewhirst MW, Hale LP
Clin Immunol 2008 Jul;128(1):66-74. Epub 2008 May 14 doi: 10.1016/j.clim.2008.02.015. PMID: 18482869Free PMC Article

Recent clinical studies

Etiology

Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Piltonen TT
Best Pract Res Clin Obstet Gynaecol 2016 Nov;37:66-79. Epub 2016 Apr 1 doi: 10.1016/j.bpobgyn.2016.03.008. PMID: 27156350
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Diagnosis

Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Milenkovic VM, Stanton EH, Nothdurfter C, Rupprecht R, Wetzel CH
Int J Mol Sci 2019 May 9;20(9) doi: 10.3390/ijms20092283. PMID: 31075818Free PMC Article
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Therapy

Belchamber KBR, Donnelly LE
Pharmacol Ther 2020 May;209:107500. Epub 2020 Feb 13 doi: 10.1016/j.pharmthera.2020.107500. PMID: 32061706
Danikowski KM, Jayaraman S, Prabhakar BS
J Neuroinflammation 2017 Jun 9;14(1):117. doi: 10.1186/s12974-017-0892-8. PMID: 28599652Free PMC Article
Rashighi M, Harris JE
Dermatol Clin 2017 Apr;35(2):257-265. doi: 10.1016/j.det.2016.11.014. PMID: 28317534Free PMC Article
Levite M, Marino F, Cosentino M
J Neural Transm (Vienna) 2017 May;124(5):525-542. Epub 2017 Mar 10 doi: 10.1007/s00702-016-1640-4. PMID: 28283756
Gruver AL, Hudson LL, Sempowski GD
J Pathol 2007 Jan;211(2):144-56. doi: 10.1002/path.2104. PMID: 17200946Free PMC Article

Prognosis

Rey-Barroso J, Munaretto A, Rouquié N, Mougel A, Chassan M, Gadat S, Dewingle O, Poincloux R, Cadot S, Ysebaert L, Quillet-Mary A, Dupré L
Haematologica 2024 Mar 1;109(3):809-823. doi: 10.3324/haematol.2022.282466. PMID: 37381758Free PMC Article
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
Haslett C, Savill JS, Meagher L
Curr Opin Immunol 1989 Oct;2(1):10-8. doi: 10.1016/0952-7915(89)90091-5. PMID: 2514726

Clinical prediction guides

Rey-Barroso J, Munaretto A, Rouquié N, Mougel A, Chassan M, Gadat S, Dewingle O, Poincloux R, Cadot S, Ysebaert L, Quillet-Mary A, Dupré L
Haematologica 2024 Mar 1;109(3):809-823. doi: 10.3324/haematol.2022.282466. PMID: 37381758Free PMC Article
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Indini A, Massi D, Pirro M, Roila F, Grossi F, Sahebkar A, Glodde N, Bald T, Mandalà M
Semin Cancer Biol 2022 Nov;86(Pt 2):477-490. Epub 2022 Jun 22 doi: 10.1016/j.semcancer.2022.06.005. PMID: 35752398
Valverde A, Nares S, Naqvi AR
Biochim Biophys Acta Gene Regul Mech 2020 Nov;1863(11):194628. Epub 2020 Sep 24 doi: 10.1016/j.bbagrm.2020.194628. PMID: 32979559Free PMC Article
Haslett C, Savill JS, Meagher L
Curr Opin Immunol 1989 Oct;2(1):10-8. doi: 10.1016/0952-7915(89)90091-5. PMID: 2514726

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