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Bone Cement Implantation Syndrome

MedGen UID:
1788799
•Concept ID:
C5442630
•
Disease or Syndrome

Definition

A rare and potentially fatal perioperative complication of cemented bone surgery, characterized by hypotension, hypoxia, cardiac dysrhythmias, and in severe cases cardiac arrest. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Cement Implantation Syndrome

Professional guidelines

PubMed

Peri-operative cardiac arrest: management and outcomes of patients analysed in the 7th National Audit Project of the Royal College of Anaesthetists.
Armstrong RA, Cook TM, Kane AD, Kursumovic E, Nolan JP, Oglesby FC, Cortes L, Taylor C, Moppett IK, Agarwal S, Cordingley J, Davies MT, Dorey J, Finney SJ, Kendall S, Kunst G, Lucas DN, Mouton R, Nickols G, Pappachan VJ, Patel B, Plaat F, Scholefield BR, Smith JH, Varney L, Wain E, Soar J; collaborators
Anaesthesia 2024 Jan;79(1):31-42. Epub 2023 Nov 16 doi: 10.1111/anae.16157. PMID: 37972480
Guideline for the management of hip fractures 2020: Guideline by the Association of Anaesthetists.
Griffiths R, Babu S, Dixon P, Freeman N, Hurford D, Kelleher E, Moppett I, Ray D, Sahota O, Shields M, White S
Anaesthesia 2021 Feb;76(2):225-237. Epub 2020 Dec 2 doi: 10.1111/anae.15291. PMID: 33289066

Recent clinical studies

Etiology

Bone cement implantation syndrome in hip arthroplasty: Frequency, severity and prevention.
Bonfait H, Delaunay C, De Thomasson E, Tracol P, Werther JR; Orthorisq
Orthop Traumatol Surg Res 2022 Apr;108(2):103139. Epub 2021 Nov 8 doi: 10.1016/j.otsr.2021.103139. PMID: 34763075
Bone cement implantation syndrome in cemented hip hemiarthroplasty-a persistent risk.
Weingärtner K, Störmann P, Schramm D, Wutzler S, Zacharowski K, Marzi I, Lustenberger T
Eur J Trauma Emerg Surg 2022 Apr;48(2):721-729. Epub 2021 Jan 26 doi: 10.1007/s00068-020-01587-8. PMID: 33495852Free PMC Article
Guideline for the management of hip fractures 2020: Guideline by the Association of Anaesthetists.
Griffiths R, Babu S, Dixon P, Freeman N, Hurford D, Kelleher E, Moppett I, Ray D, Sahota O, Shields M, White S
Anaesthesia 2021 Feb;76(2):225-237. Epub 2020 Dec 2 doi: 10.1111/anae.15291. PMID: 33289066
Understanding Bone Cement Implantation Syndrome.
Hines CB
AANA J 2018 Dec;86(6):433-441. PMID: 31584416
Bone cement implantation syndrome.
Donaldson AJ, Thomson HE, Harper NJ, Kenny NW
Br J Anaesth 2009 Jan;102(1):12-22. doi: 10.1093/bja/aen328. PMID: 19059919

Diagnosis

Regional or Neuraxial Anesthesia May Help Mitigate the Effects of Bone Cement Implantation Syndrome in Patients Undergoing Cemented Hip and Knee Arthroplasty for Oncologic Indications.
Rao SS, Suresh KV, Margalit A, Morris CD, Levin AS
J Am Acad Orthop Surg 2022 Feb 1;30(3):e375-e383. doi: 10.5435/JAAOS-D-21-00553. PMID: 34844261
Diagnosis of bone cement implantation syndrome using point of care ultrasound examination.
Huang WC, Lee P, Ling Wong TG, Tiong Tan JK, Hwang NC
Ann Card Anaesth 2021 Jul-Sep;24(3):372-374. doi: 10.4103/aca.ACA_202_19. PMID: 34269272Free PMC Article
What Are the Frequency, Related Mortality, and Factors Associated with Bone Cement Implantation Syndrome in Arthroplasty Surgery?
Rassir R, Schuiling M, Sierevelt IN, van der Hoeven CWP, Nolte PA
Clin Orthop Relat Res 2021 Apr 1;479(4):755-763. doi: 10.1097/CORR.0000000000001541. PMID: 33165048Free PMC Article
Bone cement implantation syndrome: a delayed postoperative presentation.
Singh V, Bhakta P, Zietak E, Hussain A
J Clin Anesth 2016 Jun;31:274-7. Epub 2016 Apr 18 doi: 10.1016/j.jclinane.2016.01.041. PMID: 27185726
Diagnosis and management of bone cement implantation syndrome: case report and brief review.
Kalra A, Sharma A, Palaniswamy C, El-Oshar S, Desai P, Yazbeck M, Zanotti-Cavazzoni SL
Am J Ther 2013 Jan;20(1):121-5. doi: 10.1097/MJT.0b013e31820b3de3. PMID: 21317615

Therapy

Bone cement implantation syndrome in hip arthroplasty: Frequency, severity and prevention.
Bonfait H, Delaunay C, De Thomasson E, Tracol P, Werther JR; Orthorisq
Orthop Traumatol Surg Res 2022 Apr;108(2):103139. Epub 2021 Nov 8 doi: 10.1016/j.otsr.2021.103139. PMID: 34763075
Bone cement implantation syndrome in cemented hip hemiarthroplasty-a persistent risk.
Weingärtner K, Störmann P, Schramm D, Wutzler S, Zacharowski K, Marzi I, Lustenberger T
Eur J Trauma Emerg Surg 2022 Apr;48(2):721-729. Epub 2021 Jan 26 doi: 10.1007/s00068-020-01587-8. PMID: 33495852Free PMC Article
Understanding Bone Cement Implantation Syndrome.
Hines CB
AANA J 2018 Dec;86(6):433-441. PMID: 31584416
Bone cement implantation syndrome.
Razuin R, Effat O, Shahidan MN, Shama DV, Miswan MF
Malays J Pathol 2013 Jun;35(1):87-90. PMID: 23817399
Bone cement implantation syndrome.
Donaldson AJ, Thomson HE, Harper NJ, Kenny NW
Br J Anaesth 2009 Jan;102(1):12-22. doi: 10.1093/bja/aen328. PMID: 19059919

Prognosis

Correlation between shape-closed femoral stem design and bone cement implantation syndrome in osteoporotic elderly femoral neck fracture undergoing cemented hip arthroplasty: A retrospective case-control study in 128 patients.
Chulsomlee K, Prukviwat S, Tuntiyatorn P, Vasaruchapong S, Kulachote N, Sirisreetreerux N, Tanphiriyakun T, Chanplakorn P, Sa-Ngasoongsong P
Orthop Traumatol Surg Res 2023 Feb;109(1):103450. Epub 2022 Oct 20 doi: 10.1016/j.otsr.2022.103450. PMID: 36273503
Bone Cement Implantation Syndrome in Bone Tumor Surgeries: Incidence, Risk Factors, and Clinical Experience.
Yang TH, Yang RS, Lin CP, Tseng TH
Orthop Surg 2021 Feb;13(1):109-115. Epub 2020 Dec 3 doi: 10.1111/os.12842. PMID: 33274603Free PMC Article
Occurrence, risk factors, and outcomes of bone cement implantation syndrome after hemi and total hip arthroplasty in cancer patients.
Schwarzkopf E, Sachdev R, Flynn J, Boddapati V, Padilla RE, Prince DE
J Surg Oncol 2019 Nov;120(6):1008-1015. Epub 2019 Aug 21 doi: 10.1002/jso.25675. PMID: 31432531Free PMC Article
Bone cement implantation syndrome in cemented hemiarthroplasty for femoral neck fracture: incidence, risk factors, and effect on outcome.
Olsen F, Kotyra M, Houltz E, Ricksten SE
Br J Anaesth 2014 Nov;113(5):800-6. Epub 2014 Jul 16 doi: 10.1093/bja/aeu226. PMID: 25031262
Bone cement implantation syndrome.
Razuin R, Effat O, Shahidan MN, Shama DV, Miswan MF
Malays J Pathol 2013 Jun;35(1):87-90. PMID: 23817399

Clinical prediction guides

Percutaneous Cementoplasty for the Pelvis in Bone Metastasis: 12-Year Experience.
Park JW, Lim HJ, Kang HG, Kim JH, Kim HS
Ann Surg Oncol 2022 Feb;29(2):1413-1422. Epub 2021 Aug 26 doi: 10.1245/s10434-021-10640-8. PMID: 34448054Free PMC Article
Bone cement implantation syndrome in cemented hip hemiarthroplasty-a persistent risk.
Weingärtner K, Störmann P, Schramm D, Wutzler S, Zacharowski K, Marzi I, Lustenberger T
Eur J Trauma Emerg Surg 2022 Apr;48(2):721-729. Epub 2021 Jan 26 doi: 10.1007/s00068-020-01587-8. PMID: 33495852Free PMC Article
Bone Cement Implantation Syndrome in Bone Tumor Surgeries: Incidence, Risk Factors, and Clinical Experience.
Yang TH, Yang RS, Lin CP, Tseng TH
Orthop Surg 2021 Feb;13(1):109-115. Epub 2020 Dec 3 doi: 10.1111/os.12842. PMID: 33274603Free PMC Article
The role of bone cement for the development of intraoperative hypotension and hypoxia and its impact on mortality in hemiarthroplasty for femoral neck fractures.
Olsen F, Hård Af Segerstad M, Nellgård B, Houltz E, Ricksten SE
Acta Orthop 2020 Jun;91(3):293-298. Epub 2020 Apr 2 doi: 10.1080/17453674.2020.1745510. PMID: 32237931Free PMC Article
Resuscitation in hip fractures: a systematic review.
Rocos B, Whitehouse MR, Kelly MB
BMJ Open 2017 May 4;7(4):e015906. doi: 10.1136/bmjopen-2017-015906. PMID: 28473523Free PMC Article

Recent systematic reviews

Perioperative Mortality After Cemented or Uncemented Hemiarthroplasty for Displaced Femoral Neck Fractures-A Systematic Review and Meta-analysis.
Fenelon C, Murphy EP, Pomeroy E, Murphy RP, Curtin W, Murphy CG
J Arthroplasty 2021 Feb;36(2):777-787.e1. Epub 2020 Aug 27 doi: 10.1016/j.arth.2020.08.042. PMID: 32943317
Resuscitation in hip fractures: a systematic review.
Rocos B, Whitehouse MR, Kelly MB
BMJ Open 2017 May 4;7(4):e015906. doi: 10.1136/bmjopen-2017-015906. PMID: 28473523Free PMC Article

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