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Gelatinous Bone Marrow Transformation

MedGen UID:: 1788850
•Concept ID:: C4285866
•: Disease or Syndrome

Synonym:

Serous Fat Atrophy

Definition

A rare condition characterized by bone marrow fat cell atrophy, loss of hematopoietic cells, and bone marrow deposition of extracellular gelatinous substances containing mucopolysaccharides rich in hyaluronic acid. The pathogenesis is unknown. It presents with weight loss and anemia. It has been associated with infections, alcoholism, anorexia nervosa, cachexia, end stage renal disease, and cancers. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGelatinous Bone Marrow Transformation

Pathological process
- Disease
  - Disorder by Site
    - Hematopoietic and Lymphatic System Disorder
      - Hematologic disorder
        Bone marrow disorder
        Gelatinous Bone Marrow Transformation

Professional guidelines

PubMed

Local changes in bone marrow at MRI after treatment of extremity soft tissue sarcoma.

Hwang S, Lefkowitz R, Landa J, Akin O, Schwartz LH, Cassie C, Healey JH, Alektiar KM, Panicek DM
Skeletal Radiol 2009 Jan;38(1):11-9. Epub 2008 Aug 13 doi: 10.1007/s00256-008-0560-2. PMID: 18704399

See all (1)

Recent clinical studies

Etiology

Severe neutropenia in an anorexic adolescent girl: a stigma of underfeeding syndrome?

Ibrahim N, Barruchet A, Moro MR, Blanchet C
Eat Weight Disord 2021 May;26(4):1271-1275. Epub 2020 Sep 25 doi: 10.1007/s40519-020-01016-0. PMID: 32978756

See all (1)

Diagnosis

Gelatinous transformation of bone marrow associated with ring sideroblasts: A diagnostic pitfall.

Hussain M, Rawas F, Gosnell J, Medeiros LJ, Lyapichev KA
Ann Diagn Pathol 2024 Dec;73:152385. Epub 2024 Oct 17 doi: 10.1016/j.anndiagpath.2024.152385. PMID: 39427374

Gelatinous bone marrow transformation due to extensive weight loss in median arcuate ligament syndrome.

Miguelañez Matute L, van Noord D, Rayman N, Guillen SS
BMJ Case Rep 2022 Jan 17;15(1) doi: 10.1136/bcr-2021-246916. PMID: 35039369 Free PMC Article

Resolution of gelatinous bone marrow transformation following hormone replacement therapy in a patient with primary insufficiency of the adrenal and thyroid glands.

Obata Y, Tamba S, Yamada Y, Kyo M, Takahi Y, Saisho K, Yamato A, Hattori K, Ujiie H, Fujita S, Yamamoto K, Matsuzawa Y
Intern Med 2013;52(17):1931-6. doi: 10.2169/internalmedicine.52.0081. PMID: 23994986

Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature.

Nakanishi R, Ishida M, Hodohara K, Yoshida T, Yoshii M, Okuno H, Horinouchi A, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2013;6(8):1677-82. Epub 2013 Jul 15 PMID: 23923088 Free PMC Article

Gelatinous bone marrow transformation secondary to unusual eating habits and drastic weight loss.

Rafiullah, Islam R, Mahmood R, Sitwala KV
BMJ Case Rep 2013 Jul 16;2013 doi: 10.1136/bcr-2013-200243. PMID: 23861277 Free PMC Article

See all (7)

Therapy

Gelatinous bone marrow transformation and emergence of clonal Philadelphia-negative cytogenetic abnormalities with excess blasts in a patient with chronic myeloid leukemia treated with dasatinib.

Hermel DJ, Nael A, Lu YT, Kim J, Brynes RK, Vergara-Lluri M, Akhtari M
Anticancer Drugs 2019 Apr;30(4):416-421. doi: 10.1097/CAD.0000000000000763. PMID: 30875349

Gelatinous bone marrow transformation complicated by self-induced malnutrition.

Nonaka D, Tanaka M, Takaki K, Umeno M, Okamura T, Taketa H
Acta Haematol 1998;100(2):88-90. doi: 10.1159/000040872. PMID: 9792939

See all (2)

Prognosis

Extremely severe anorexia nervosa: Hospital course of 354 adult patients in a clinical nutrition-eating disorders-unit.

Guinhut M, Melchior JC, Godart N, Hanachi M
Clin Nutr 2021 Apr;40(4):1954-1965. Epub 2020 Sep 17 doi: 10.1016/j.clnu.2020.09.011. PMID: 33023762

Severe neutropenia in an anorexic adolescent girl: a stigma of underfeeding syndrome?

Ibrahim N, Barruchet A, Moro MR, Blanchet C
Eat Weight Disord 2021 May;26(4):1271-1275. Epub 2020 Sep 25 doi: 10.1007/s40519-020-01016-0. PMID: 32978756

Gelatinous bone marrow transformation and emergence of clonal Philadelphia-negative cytogenetic abnormalities with excess blasts in a patient with chronic myeloid leukemia treated with dasatinib.

Hermel DJ, Nael A, Lu YT, Kim J, Brynes RK, Vergara-Lluri M, Akhtari M
Anticancer Drugs 2019 Apr;30(4):416-421. doi: 10.1097/CAD.0000000000000763. PMID: 30875349

The hematology of anorexia nervosa.

Hütter G, Ganepola S, Hofmann WK
Int J Eat Disord 2009 May;42(4):293-300. doi: 10.1002/eat.20610. PMID: 19040272

Gelatinous bone marrow transformation in a case of idiopathic myelofibrosis: a morphological paradox.

Böhm J, Schmitt-Gräff A
Pathol Res Pract 2000;196(11):775-9. doi: 10.1016/S0344-0338(00)80111-9. PMID: 11186174

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Clinical prediction guides

Severe neutropenia in an anorexic adolescent girl: a stigma of underfeeding syndrome?

Ibrahim N, Barruchet A, Moro MR, Blanchet C
Eat Weight Disord 2021 May;26(4):1271-1275. Epub 2020 Sep 25 doi: 10.1007/s40519-020-01016-0. PMID: 32978756

Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature.

Gelatinous bone marrow transformation secondary to unusual eating habits and drastic weight loss.

Rafiullah, Islam R, Mahmood R, Sitwala KV
BMJ Case Rep 2013 Jul 16;2013 doi: 10.1136/bcr-2013-200243. PMID: 23861277 Free PMC Article

The hematology of anorexia nervosa.

Hütter G, Ganepola S, Hofmann WK
Int J Eat Disord 2009 May;42(4):293-300. doi: 10.1002/eat.20610. PMID: 19040272

See all (4)