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Primary vesicoureteral reflux

MedGen UID:
1788979
•Concept ID:
C5539786
•
Disease or Syndrome
Synonyms: Primary Vesicoureteral Reflux; Reflux, Primary Vesicoureteral; Vesicoureteral Reflux, Primary
 
HPO: HP:0033738

Definition

Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary vesicoureteral reflux

Professional guidelines

PubMed

Current options in the management of primary vesicoureteral reflux in children.
Fonseca FF, Tanno FY, Nguyen HT
Pediatr Clin North Am 2012 Aug;59(4):819-34. Epub 2012 Jun 22 doi: 10.1016/j.pcl.2012.05.012. PMID: 22857830
Endoscopic treatment of primary vesicoureteral reflux.
Diamond DA, Mattoo TK
N Engl J Med 2012 Mar 29;366(13):1218-26. doi: 10.1056/NEJMct1108922. PMID: 22455416
Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children.
Peters CA, Skoog SJ, Arant BS Jr, Copp HL, Elder JS, Hudson RG, Khoury AE, Lorenzo AJ, Pohl HG, Shapiro E, Snodgrass WT, Diaz M
J Urol 2010 Sep;184(3):1134-44. Epub 2010 Jul 21 doi: 10.1016/j.juro.2010.05.065. PMID: 20650499

Recent clinical studies

Etiology

Primary Vesicoureteral Reflux and Renal Scarring.
Mattoo TK, Mohammad D
Pediatr Clin North Am 2022 Dec;69(6):1115-1129. Epub 2022 Oct 29 doi: 10.1016/j.pcl.2022.07.007. PMID: 36880925
Evaluation of Renal Function and Scars in Children With Primary Vesicoureteral Reflux.
Marcellino A, Bloise S, Fraternali R, Pirone C, Brandino G, Testa A, Filippi L, Lubrano R
Urology 2022 Oct;168:195-200. Epub 2022 Jun 30 doi: 10.1016/j.urology.2022.06.020. PMID: 35780944
Intrarenal reflux in primary vesicoureteral reflux.
Fukui S, Watanabe M, Yoshino K
Int J Urol 2013 Jun;20(6):631-6. Epub 2012 Nov 27 doi: 10.1111/iju.12015. PMID: 23186044
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
Primary ureteral reflux: emerging insights from molecular and genetic studies.
Mak RH, Kuo HJ
Curr Opin Pediatr 2003 Apr;15(2):181-5. doi: 10.1097/00008480-200304000-00007. PMID: 12640275

Diagnosis

Primary Vesicoureteral Reflux and Renal Scarring.
Mattoo TK, Mohammad D
Pediatr Clin North Am 2022 Dec;69(6):1115-1129. Epub 2022 Oct 29 doi: 10.1016/j.pcl.2022.07.007. PMID: 36880925
Primary Vesicoureteral reflux and chronic kidney disease in pediatric population. What we have learnt?
Andrioli V, Regacini R, Aguiar W
Int Braz J Urol 2020 Mar-Apr;46(2):262-268. doi: 10.1590/S1677-5538.IBJU.2020.02.02. PMID: 32022517Free PMC Article
Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?
Garin EH
Pediatr Nephrol 2019 Sep;34(9):1513-1519. Epub 2018 Aug 21 doi: 10.1007/s00467-018-4045-9. PMID: 30132079
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
Primary ureteral reflux: emerging insights from molecular and genetic studies.
Mak RH, Kuo HJ
Curr Opin Pediatr 2003 Apr;15(2):181-5. doi: 10.1097/00008480-200304000-00007. PMID: 12640275

Therapy

Can distal ureteral diameter measurement predict primary vesicoureteral reflux clinical outcome and success of endoscopic injection?
Payza AD, Hoşgör M, Serdaroğlu E, Sencan A
J Pediatr Urol 2019 Oct;15(5):515.e1-515.e8. Epub 2019 Jul 13 doi: 10.1016/j.jpurol.2019.07.005. PMID: 31420285
Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?
Garin EH
Pediatr Nephrol 2019 Sep;34(9):1513-1519. Epub 2018 Aug 21 doi: 10.1007/s00467-018-4045-9. PMID: 30132079
EAU guidelines on vesicoureteral reflux in children.
Tekgül S, Riedmiller H, Hoebeke P, Kočvara R, Nijman RJ, Radmayr C, Stein R, Dogan HS; European Association of Urology
Eur Urol 2012 Sep;62(3):534-42. Epub 2012 Jun 5 doi: 10.1016/j.eururo.2012.05.059. PMID: 22698573
Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children.
Peters CA, Skoog SJ, Arant BS Jr, Copp HL, Elder JS, Hudson RG, Khoury AE, Lorenzo AJ, Pohl HG, Shapiro E, Snodgrass WT, Diaz M
J Urol 2010 Sep;184(3):1134-44. Epub 2010 Jul 21 doi: 10.1016/j.juro.2010.05.065. PMID: 20650499
Primary vesicoureteral reflux: review of current concepts.
Garin EH, Campos A, Homsy Y
Pediatr Nephrol 1998 Apr;12(3):249-56. doi: 10.1007/s004670050448. PMID: 9630048

Prognosis

Vesicoureteral Reflux Index: Predicting Primary Vesicoureteral Reflux Resolution in Children Diagnosed after Age 24 Months.
Garcia-Roig M, Ridley DE, McCracken C, Arlen AM, Cooper CS, Kirsch AJ
J Urol 2017 Apr;197(4):1150-1157. Epub 2016 Dec 9 doi: 10.1016/j.juro.2016.12.008. PMID: 27939835
Primary vesicoureteral reflux: A 26-year experience in a single centre.
Vachvanichsanong P, Dissaneewate P, McNeil E
Nephrology (Carlton) 2016 Apr;21(4):335-40. doi: 10.1111/nep.12615. PMID: 26370584
Vesicoureteral Reflux Index: 2-Institution Analysis and Validation.
Arlen AM, Garcia-Roig M, Weiss AD, Leong T, Cooper CS, Kirsch AJ
J Urol 2016 Apr;195(4 Pt 2):1294-9. Epub 2015 Mar 23 doi: 10.1016/j.juro.2015.03.094. PMID: 25813448
Clinical Course and Effective Factors of Primary Vesicoureteral Reflux.
Nickavar A, Hajizadeh N, Lahouti Harahdashti A
Acta Med Iran 2015;53(6):376-9. PMID: 26069177
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article

Clinical prediction guides

Armamentarium to treat primary vesicoureteral reflux in children.
Arlen AM, Kirsch AJ
Semin Pediatr Surg 2021 Aug;30(4):151086. Epub 2021 Jul 15 doi: 10.1016/j.sempedsurg.2021.151086. PMID: 34412883
Vesicoureteral Reflux Index: 2-Institution Analysis and Validation.
Arlen AM, Garcia-Roig M, Weiss AD, Leong T, Cooper CS, Kirsch AJ
J Urol 2016 Apr;195(4 Pt 2):1294-9. Epub 2015 Mar 23 doi: 10.1016/j.juro.2015.03.094. PMID: 25813448
Clinical Course and Effective Factors of Primary Vesicoureteral Reflux.
Nickavar A, Hajizadeh N, Lahouti Harahdashti A
Acta Med Iran 2015;53(6):376-9. PMID: 26069177
Intrarenal reflux in primary vesicoureteral reflux.
Fukui S, Watanabe M, Yoshino K
Int J Urol 2013 Jun;20(6):631-6. Epub 2012 Nov 27 doi: 10.1111/iju.12015. PMID: 23186044
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article

Recent systematic reviews

Effectiveness and risks of endoscopic management compared to vesicoureteral reimplantation in patients with high-grade vesicoureteral reflux: systematic review and network meta-analysis.
Mina-Riascos SH, Fernández N, García-Perdomo HA
Eur J Pediatr 2021 May;180(5):1383-1391. Epub 2021 Jan 20 doi: 10.1007/s00431-021-03948-w. PMID: 33474581

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