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Pleomorphic Leiomyosarcoma

MedGen UID:
1790039
Concept ID:
C4761201
Neoplastic Process

Definition

A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Leiomyosarcoma

Professional guidelines

PubMed

Agaimy A, Gaumann A, Schroeder J, Dietmaier W, Hartmann A, Hofstaedter F, Wünsch PH, Mentzel T
Virchows Arch 2007 Nov;451(5):949-57. Epub 2007 Sep 14 doi: 10.1007/s00428-007-0495-3. PMID: 17874130

Recent clinical studies

Etiology

Kanthan R, Senger JL, Kanthan S
World J Surg Oncol 2012 Apr 27;10:64. doi: 10.1186/1477-7819-10-64. PMID: 22540324Free PMC Article
Kawai A, Kondo T, Suehara Y, Kikuta K, Hirohashi S
Clin Orthop Relat Res 2008 Sep;466(9):2099-106. Epub 2008 Jun 6 doi: 10.1007/s11999-008-0330-4. PMID: 18535868Free PMC Article
Thijssens KM, van Ginkel RJ, Suurmeijer AJ, Pras E, van der Graaf WT, Hollander M, Hoekstra HJ
Ann Surg Oncol 2005 Mar;12(3):237-45. Epub 2005 Mar 3 doi: 10.1245/ASO.2005.03.041. PMID: 15827816
Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M
Pathol Int 2002 Sep;52(9):595-606. doi: 10.1046/j.1440-1827.2002.01399.x. PMID: 12406189
Miyajima K, Oda Y, Oshiro Y, Tamiya S, Kinukawa N, Masuda K, Tsuneyoshi M
Histopathology 2002 Apr;40(4):353-9. doi: 10.1046/j.1365-2559.2002.01361.x. PMID: 11943020

Diagnosis

Oettel DJ, Bernard SA
Skeletal Radiol 2023 Mar;52(3):435-445. Epub 2022 Jul 22 doi: 10.1007/s00256-022-04127-0. PMID: 35867123
Smith CT, Grider DJ
Am J Dermatopathol 2021 Jun 1;43(6):446-449. doi: 10.1097/DAD.0000000000001896. PMID: 33464746
Zhang QY, Shen QY, Yan S, Zheng SS
J Int Med Res 2011;39(4):1555-62. doi: 10.1177/147323001103900447. PMID: 21986161
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
de Jong AS, van Kessel-van Vark M, Albus-Lutter CE
Hum Pathol 1987 Mar;18(3):298-303. doi: 10.1016/s0046-8177(87)80013-8. PMID: 3028931

Therapy

Sagara K, Takayoshi K, Kusumoto E, Uchino K, Matsumura T, Kusaba H, Momosaki S, Ikejiri K, Baba E
BMC Res Notes 2014 Jun 19;7:377. doi: 10.1186/1756-0500-7-377. PMID: 24947892Free PMC Article
Gupta S, Husain N, Kumar A, Sunder S
J Cancer Res Ther 2012 Jul-Sep;8(3):448-50. doi: 10.4103/0973-1482.103532. PMID: 23174734
Mohanty SK, Balani JP, Parwani AV
Urology 2007 Sep;70(3):591.e5-7. doi: 10.1016/j.urology.2007.07.029. PMID: 17905130

Prognosis

Laforga JB, Cortés VA
Rev Esp Patol 2020 Jan-Mar;53(1):61-65. Epub 2018 Jul 26 doi: 10.1016/j.patol.2018.06.002. PMID: 31932012
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Kanthan R, Senger JL, Kanthan S
World J Surg Oncol 2012 Apr 27;10:64. doi: 10.1186/1477-7819-10-64. PMID: 22540324Free PMC Article
Zhang QY, Shen QY, Yan S, Zheng SS
J Int Med Res 2011;39(4):1555-62. doi: 10.1177/147323001103900447. PMID: 21986161
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287

Clinical prediction guides

Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M
Pathol Int 2002 Sep;52(9):595-606. doi: 10.1046/j.1440-1827.2002.01399.x. PMID: 12406189
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
Oshiro Y, Shiratsuchi H, Oda Y, Toyoshima S, Tsuneyoshi M
Mod Pathol 2000 Nov;13(11):1211-8. doi: 10.1038/modpathol.3880225. PMID: 11106079

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