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Fetal Retinoid Syndrome

MedGen UID:
1790199
•Concept ID:
C5550990
•
Disease or Syndrome
Synonym: Retinoic Acid Embryopathy

Definition

A teratogenic disorder observed in a newborn or child of a mother who was exposed to retinoids during pregnancy. Manifestations include growth delay, skull, facial, heart, and central nervous system malformations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal Retinoid Syndrome

Professional guidelines

PubMed

Treatment of acute promyelocytic leukemia during pregnancy.
Yang D, Hladnik L
Pharmacotherapy 2009 Jun;29(6):709-24. doi: 10.1592/phco.29.6.709. PMID: 19476422
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome.
Yoon KC, Im SK, Park YG, Jung YD, Yang SY, Choi J
Cornea 2006 Apr;25(3):268-72. doi: 10.1097/01.ico.0000183484.85636.b6. PMID: 16633024

Recent clinical studies

Etiology

Communication development of a young child with foetal retinoid syndrome: a seven-year follow-up study.
Kritzinger A, Steenkamp L
S Afr J Commun Disord 2006;53:39-48. PMID: 20218489
Congenital oculomotor nerve synkinesis associated with fetal retinoid syndrome.
Morrison DG, Elsas FJ, Descartes M
J AAPOS 2005 Apr;9(2):166-8. doi: 10.1016/j.jaapos.2004.12.017. PMID: 15838445

Diagnosis

Antenatal Diagnosis of Fetal Retinoid Syndrome at 20 Weeks of Gestation: A Case Report.
Erenel H, Ozel A, Oztunc F, Kizilkilic O, Comunoglu N, Uludag S, Madazli R
Fetal Pediatr Pathol 2018 Aug;37(4):282-286. Epub 2018 May 29 doi: 10.1080/15513815.2018.1472354. PMID: 29843537
Congenital oculomotor nerve synkinesis associated with fetal retinoid syndrome.
Morrison DG, Elsas FJ, Descartes M
J AAPOS 2005 Apr;9(2):166-8. doi: 10.1016/j.jaapos.2004.12.017. PMID: 15838445

Therapy

Antenatal Diagnosis of Fetal Retinoid Syndrome at 20 Weeks of Gestation: A Case Report.
Erenel H, Ozel A, Oztunc F, Kizilkilic O, Comunoglu N, Uludag S, Madazli R
Fetal Pediatr Pathol 2018 Aug;37(4):282-286. Epub 2018 May 29 doi: 10.1080/15513815.2018.1472354. PMID: 29843537
Communication development of a young child with foetal retinoid syndrome: a seven-year follow-up study.
Kritzinger A, Steenkamp L
S Afr J Commun Disord 2006;53:39-48. PMID: 20218489
Congenital oculomotor nerve synkinesis associated with fetal retinoid syndrome.
Morrison DG, Elsas FJ, Descartes M
J AAPOS 2005 Apr;9(2):166-8. doi: 10.1016/j.jaapos.2004.12.017. PMID: 15838445

Prognosis

Communication development of a young child with foetal retinoid syndrome: a seven-year follow-up study.
Kritzinger A, Steenkamp L
S Afr J Commun Disord 2006;53:39-48. PMID: 20218489
Congenital oculomotor nerve synkinesis associated with fetal retinoid syndrome.
Morrison DG, Elsas FJ, Descartes M
J AAPOS 2005 Apr;9(2):166-8. doi: 10.1016/j.jaapos.2004.12.017. PMID: 15838445

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