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Serous Tubal Intraepithelial Lesion

MedGen UID:
1790640
•Concept ID:
C5552772
•
Neoplastic Process

Definition

A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerous Tubal Intraepithelial Lesion

Professional guidelines

PubMed

Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study.
Bogaerts JMA, van Bommel MHD, Hermens RPMG, Steenbeek MP, de Hullu JA, van der Laak JAWM; STIC consortium, Simons M
Histopathology 2023 Jul;83(1):67-79. Epub 2023 Mar 20 doi: 10.1111/his.14902. PMID: 36939551
Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Recent clinical studies

Etiology

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Sectioning and extensively examining the fimbriated end (SEE-FIM) of the fallopian tube in routine practices, is it worth the effort?
Laokulrath N, Warnnissorn M, Chuangsuwanich T, Hanamornroongruang S
J Obstet Gynaecol Res 2019 Mar;45(3):665-670. Epub 2018 Dec 2 doi: 10.1111/jog.13845. PMID: 30506766
Incidence of serous tubal intraepithelial carcinoma (STIC) by algorithm classification in serous ovarian tumor associated with PAX8 expression in tubal epithelia: a study of single institution in Japan.
Munakata S, Yamamoto T
Int J Gynecol Pathol 2015 Jan;34(1):9-18. doi: 10.1097/PGP.0000000000000108. PMID: 25473747Free PMC Article
Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery.
Rabban JT, Garg K, Crawford B, Chen LM, Zaloudek CJ
Am J Surg Pathol 2014 Jun;38(6):729-42. doi: 10.1097/PAS.0000000000000199. PMID: 24820399
Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma.
Vang R, Visvanathan K, Gross A, Maambo E, Gupta M, Kuhn E, Li RF, Ronnett BM, Seidman JD, Yemelyanova A, Shih IeM, Shaw PA, Soslow RA, Kurman RJ
Int J Gynecol Pathol 2012 May;31(3):243-53. doi: 10.1097/PGP.0b013e31823b8831. PMID: 22498942Free PMC Article

Diagnosis

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions.
Wu RC, Wang P, Lin SF, Zhang M, Song Q, Chu T, Wang BG, Kurman RJ, Vang R, Kinzler K, Tomasetti C, Jiao Y, Shih IM, Wang TL
J Pathol 2019 May;248(1):41-50. Epub 2019 Feb 15 doi: 10.1002/path.5219. PMID: 30560554Free PMC Article
Incidence of serous tubal intraepithelial carcinoma (STIC) by algorithm classification in serous ovarian tumor associated with PAX8 expression in tubal epithelia: a study of single institution in Japan.
Munakata S, Yamamoto T
Int J Gynecol Pathol 2015 Jan;34(1):9-18. doi: 10.1097/PGP.0000000000000108. PMID: 25473747Free PMC Article
Serous tubal in situ carcinoma (STIC) in primary peritoneal serous carcinomas.
Horn LC, Kafkova S, Leonhardt K, Kellner C, Einenkel J
Int J Gynecol Pathol 2013 Jul;32(4):339-44. doi: 10.1097/PGP.0b013e31826a629b. PMID: 23722505
Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma.
Vang R, Visvanathan K, Gross A, Maambo E, Gupta M, Kuhn E, Li RF, Ronnett BM, Seidman JD, Yemelyanova A, Shih IeM, Shaw PA, Soslow RA, Kurman RJ
Int J Gynecol Pathol 2012 May;31(3):243-53. doi: 10.1097/PGP.0b013e31823b8831. PMID: 22498942Free PMC Article

Therapy

Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery.
Rabban JT, Garg K, Crawford B, Chen LM, Zaloudek CJ
Am J Surg Pathol 2014 Jun;38(6):729-42. doi: 10.1097/PAS.0000000000000199. PMID: 24820399

Prognosis

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Pathological findings and long-term prognosis in Korean BRCA1/2 mutation carriers undergoing risk-reducing salpingo-oophorectomy.
Kang OJ, Lee SW, Kim JH, Park JY, Suh DS, Kim DY, Kim JH, Kim YM, Kim YT
Int J Gynecol Cancer 2023 Nov 6;33(11):1743-1749. doi: 10.1136/ijgc-2023-004618. PMID: 37541685
Incidence of serous tubal intraepithelial carcinoma (STIC) by algorithm classification in serous ovarian tumor associated with PAX8 expression in tubal epithelia: a study of single institution in Japan.
Munakata S, Yamamoto T
Int J Gynecol Pathol 2015 Jan;34(1):9-18. doi: 10.1097/PGP.0000000000000108. PMID: 25473747Free PMC Article
Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery.
Rabban JT, Garg K, Crawford B, Chen LM, Zaloudek CJ
Am J Surg Pathol 2014 Jun;38(6):729-42. doi: 10.1097/PAS.0000000000000199. PMID: 24820399
Use of cervical mucus to screen for gynecological malignancies: a pilot study.
Lamzabi I, Buckingham L, Gebrekiristos M, Jain R, Gattuso P, Reddy V, Guirguis A, Dewdney S, Rotmensch J, Bitterman P
Mod Pathol 2013 Nov;26(11):1508-13. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.92. PMID: 23765243

Clinical prediction guides

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions.
Wu RC, Wang P, Lin SF, Zhang M, Song Q, Chu T, Wang BG, Kurman RJ, Vang R, Kinzler K, Tomasetti C, Jiao Y, Shih IM, Wang TL
J Pathol 2019 May;248(1):41-50. Epub 2019 Feb 15 doi: 10.1002/path.5219. PMID: 30560554Free PMC Article
Incidence of serous tubal intraepithelial carcinoma (STIC) by algorithm classification in serous ovarian tumor associated with PAX8 expression in tubal epithelia: a study of single institution in Japan.
Munakata S, Yamamoto T
Int J Gynecol Pathol 2015 Jan;34(1):9-18. doi: 10.1097/PGP.0000000000000108. PMID: 25473747Free PMC Article
Serous tubal in situ carcinoma (STIC) in primary peritoneal serous carcinomas.
Horn LC, Kafkova S, Leonhardt K, Kellner C, Einenkel J
Int J Gynecol Pathol 2013 Jul;32(4):339-44. doi: 10.1097/PGP.0b013e31826a629b. PMID: 23722505
Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma.
Vang R, Visvanathan K, Gross A, Maambo E, Gupta M, Kuhn E, Li RF, Ronnett BM, Seidman JD, Yemelyanova A, Shih IeM, Shaw PA, Soslow RA, Kurman RJ
Int J Gynecol Pathol 2012 May;31(3):243-53. doi: 10.1097/PGP.0b013e31823b8831. PMID: 22498942Free PMC Article

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