Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Infantile Myofibroma

MedGen UID:: 1790678
•Concept ID:: C5552811
•: Neoplastic Process

Definition

A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVInfantile Myofibroma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign connective and soft tissue neoplasm
      - Benign perivascular tumor
        Myofibroma
        Infantile Myofibroma

Professional guidelines

PubMed

Clinical utility of vinblastine therapeutic drug monitoring for the treatment of infantile myofibroma patients: A case series.

Carruthers V, Barnett S, Rees R, Arif T, Slater O, Ramanujachar R, Johnson K, Brown S, Graham C, Burke GAA, Veal GJ
Pediatr Blood Cancer 2022 Jul;69(7):e29722. Epub 2022 Apr 20 doi: 10.1002/pbc.29722. PMID: 35441483

See all (1)

Recent clinical studies

Etiology

Nonepithelial Tumors and Tumor-like Lesions of the Skin and Subcutis in Children.

Dehner LP, Gru AA
Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207. doi: 10.1177/1093526617751529. PMID: 29607758

Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas.

Agaimy A, Bieg M, Michal M, Geddert H, Märkl B, Seitz J, Moskalev EA, Schlesner M, Metzler M, Hartmann A, Wiemann S, Michal M, Mentzel T, Haller F
Am J Surg Pathol 2017 Feb;41(2):195-203. doi: 10.1097/PAS.0000000000000752. PMID: 27776010

Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesions.

Merrell SC, Rahbar R, Alomari AI, Padua HM, Vargas SO, Neufeld EJ, Dearden JL, Mulliken JB, Greene AK
J Craniofac Surg 2010 Mar;21(2):422-6. doi: 10.1097/SCS.0b013e3181cfa777. PMID: 20186073

Primary skull lesions in the pediatric population: a 25-year experience.

Gibson SE, Prayson RA
Arch Pathol Lab Med 2007 May;131(5):761-6. doi: 10.5858/2007-131-761-PSLITP. PMID: 17488162

Infantile myofibromatosis of orbital bone. A case report with computed tomography, magnetic resonance imaging, and histologic findings.

Duffy MT, Harris M, Hornblass A
Ophthalmology 1997 Sep;104(9):1471-4. doi: 10.1016/s0161-6420(97)30114-6. PMID: 9307643

See all (7)

Diagnosis

Periorbital Myofibroma in a Child: A Case Report and Review of the Literature.

Sim B, Gal A, Tumuluri K
Ophthalmic Plast Reconstr Surg 2020 Sep/Oct;36(5):e127-e128. doi: 10.1097/IOP.0000000000001632. PMID: 32251175

Nonepithelial Tumors and Tumor-like Lesions of the Skin and Subcutis in Children.

Dehner LP, Gru AA
Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207. doi: 10.1177/1093526617751529. PMID: 29607758

Congenital Vascular Tumors.

Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070

Ruptured Infantile Myofibroma of the Head Presenting in a Neonate: Case Report and Review of the Literature.

Koch PF, Fierst T, Heuer AJ, Santi M, Heuer GG
World Neurosurg 2017 Feb;98:884.e13-884.e18. Epub 2015 Oct 13 doi: 10.1016/j.wneu.2015.09.106. PMID: 26459706

Fetal neck myofibroma.

Wataganara T, Ngerncham S, Kitsommart R, Fuangtharnthip P
J Med Assoc Thai 2007 Feb;90(2):376-80. PMID: 17375646

See all (39)

Therapy

Solitary infantile myofibroma compromising the airway.

Eze N, Pitkin L, Crowley S, Wilson P, Daya H
Int J Pediatr Otorhinolaryngol 2004 Dec;68(12):1533-7. doi: 10.1016/j.ijporl.2004.04.035. PMID: 15533567

See all (1)

Prognosis

Pediatric Subcutaneous Scalp Mass: A Case Report and Review.

Debbaneh PM, Zou Y, Zim S
Perm J 2022 Jun 29;26(2):149-152. Epub 2022 Jun 15 doi: 10.7812/TPP/21.184. PMID: 35933658 Free PMC Article

Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series.

Lopes RN, Alves Fde A, Rocha AC, Suassuna TM, Kowalski LP, de Castro JF, Perez DE
Acta Histochem 2015 May-Jun;117(4-5):431-6. Epub 2015 Mar 3 doi: 10.1016/j.acthis.2015.02.001. PMID: 25744090

Orbital infantile myofibroma: a case report and clinicopathologic review of 24 cases from the literature.

Mynatt CJ, Feldman KA, Thompson LD
Head Neck Pathol 2011 Sep;5(3):205-15. Epub 2011 Apr 22 doi: 10.1007/s12105-011-0260-4. PMID: 21512784 Free PMC Article

Congenital cranio-orbital myofibroma.

Yazici B, Bilge AD, Yazici Z, Yalçinkaya U
Ophthalmic Plast Reconstr Surg 2011 Jul-Aug;27(4):e108-11. doi: 10.1097/IOP.0b013e3181fc05f8. PMID: 21088629

Infantile myofibroma: a case report and review of the literature.

Schurr P, Moulsdale W
Adv Neonatal Care 2008 Feb;8(1):13-20. doi: 10.1097/01.ANC.0000311012.63887.fb. PMID: 18300734

See all (19)

Clinical prediction guides

Isolated infantile myofibroma of the calvarium: Report of a case with a literature review.

Demir MK, Yapicier O, Celik O, Ertem O, Kilic D
Childs Nerv Syst 2024 Apr;40(4):1277-1284. Epub 2024 Jan 15 doi: 10.1007/s00381-024-06289-9. PMID: 38224363

Clinical utility of vinblastine therapeutic drug monitoring for the treatment of infantile myofibroma patients: A case series.

Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series.

Lopes RN, Alves Fde A, Rocha AC, Suassuna TM, Kowalski LP, de Castro JF, Perez DE
Acta Histochem 2015 May-Jun;117(4-5):431-6. Epub 2015 Mar 3 doi: 10.1016/j.acthis.2015.02.001. PMID: 25744090

Myofibroma of the conjunctiva invading the cornea in infancy.

Lascaratos G, Gupta M, Bridges L, MacRae M
J Pediatr Ophthalmol Strabismus 2010 May 21;47 Online:e1-3. doi: 10.3928/01913913-20100510-05. PMID: 21214145

See all (4)

MedGen

National Center for Biotechnology Information