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Microsatellite Stable Colon Carcinoma

MedGen UID:
1791055
•Concept ID:
C5554614
•
Neoplastic Process

Definition

Colon carcinoma characterized by the absence of microsatellite instability. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrosatellite Stable Colon Carcinoma

Professional guidelines

PubMed

Comparative analyses of the prognosis, tumor immune microenvironment, and drug treatment response between left-sided and right-sided colon cancer by integrating scRNA-seq and bulk RNA-seq data.
Cao L, Zhang S, Yao D, Ba Y, Weng Q, Yang J, Zhang H, Ren Y
Aging (Albany NY) 2023 Jul 21;15(14):7098-7123. doi: 10.18632/aging.204894. PMID: 37480572Free PMC Article
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using image processing software analysis for Ki67 immunohistochemistry.
Fujimori Y, Fujimori T, Imura J, Sugai T, Yao T, Wada R, Ajioka Y, Ohkura Y
Diagn Pathol 2012 May 29;7:59. doi: 10.1186/1746-1596-7-59. PMID: 22642724Free PMC Article

Recent clinical studies

Etiology

The Current and Evolving Role of Immunotherapy in Metastatic Colorectal Cancer.
Silva VS, Riechelmann RP, Mello CA, Felismino T, Taboada R
Curr Cancer Drug Targets 2022 Aug 15;22(8):617-628. doi: 10.2174/1568009622666220224110912. PMID: 35209820
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R; Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW
Cancer Cell 2018 Apr 9;33(4):721-735.e8. Epub 2018 Apr 2 doi: 10.1016/j.ccell.2018.03.010. PMID: 29622466Free PMC Article
Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review.
Nejadtaghi M, Jafari H, Farrokhi E, Samani KG
Curr Probl Cancer 2017 Nov-Dec;41(6):388-397. Epub 2017 Oct 18 doi: 10.1016/j.currproblcancer.2017.10.002. PMID: 29096939
The serrated pathway to colorectal carcinoma: current concepts and challenges.
Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V
Histopathology 2013 Feb;62(3):367-86. doi: 10.1111/his.12055. PMID: 23339363

Diagnosis

Clinicopathological Characteristics and Outcome of Adolescent and Young Adult-Onset Microsatellite Stable Colorectal Cancer Patients.
Sukhokanjanachusak K, Pongpaibul A, Nimmannit A, Akewanlop C, Korphaisarn K
J Adolesc Young Adult Oncol 2021 Oct;10(5):573-580. Epub 2020 Oct 20 doi: 10.1089/jayao.2020.0144. PMID: 33085547
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Diagnostic and reporting issues of preneoplastic polyps of the large intestine with early carcinoma.
Snover DC
Ann Diagn Pathol 2019 Apr;39:1-14. Epub 2018 Dec 22 doi: 10.1016/j.anndiagpath.2018.11.001. PMID: 30597401
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers.
Wolff RK, Hoffman MD, Wolff EC, Herrick JS, Sakoda LC, Samowitz WS, Slattery ML
Genes Chromosomes Cancer 2018 Jul;57(7):366-376. Epub 2018 Apr 30 doi: 10.1002/gcc.22539. PMID: 29575536Free PMC Article
Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review.
Nejadtaghi M, Jafari H, Farrokhi E, Samani KG
Curr Probl Cancer 2017 Nov-Dec;41(6):388-397. Epub 2017 Oct 18 doi: 10.1016/j.currproblcancer.2017.10.002. PMID: 29096939

Therapy

Long-term response to sintilimab, bevacizumab and chemotherapy in heavily pretreated microsatellite stable colon cancer.
Cui Z, Wang Q, Deng M, Meng E, Liu S, Niu B, Han Q
Immunotherapy 2023 Feb;15(3):127-133. Epub 2023 Feb 1 doi: 10.2217/imt-2022-0058. PMID: 36722149
Overuse and Limited Benefit of Chemotherapy for Stage II Colon Cancer in Young Patients.
Birkett RT, Chamely E, Concors SJ, Bleier JI, Aarons CB, Shanmugan S, Saur NM, Paulson EC
Clin Colorectal Cancer 2019 Dec;18(4):292-300. Epub 2019 Apr 6 doi: 10.1016/j.clcc.2019.04.002. PMID: 31447135
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer.
Taieb J, Le Malicot K, Shi Q, Penault-Llorca F, Bouché O, Tabernero J, Mini E, Goldberg RM, Folprecht G, Luc Van Laethem J, Sargent DJ, Alberts SR, Emile JF, Laurent Puig P, Sinicrope FA
J Natl Cancer Inst 2017 May;109(5) Epub 2016 Dec 31 doi: 10.1093/jnci/djw272. PMID: 28040692Free PMC Article
Dietary factors and microsatellite instability in sporadic colon carcinomas.
Diergaarde B, Braam H, van Muijen GN, Ligtenberg MJ, Kok FJ, Kampman E
Cancer Epidemiol Biomarkers Prev 2003 Nov;12(11 Pt 1):1130-6. PMID: 14652271

Prognosis

Presence of Tim3(+) and PD-1(+) CD8(+) T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features.
Klapholz M, Drage MG, Srivastava A, Anderson AC
J Pathol 2022 Jun;257(2):186-197. Epub 2022 Apr 9 doi: 10.1002/path.5877. PMID: 35119692
Is Microsatellite Status Associated With Prognosis in Stage II Colon Cancer With High-Risk Features?
Cavallaro PM, Stafford C, Cauley CE, Berger DL, Bordeianou L, Kunitake H, Francone T, Ricciardi R
Dis Colon Rectum 2021 May;64(5):545-554. doi: 10.1097/DCR.0000000000001914. PMID: 33939386Free PMC Article
Clinicopathological Characteristics and Outcome of Adolescent and Young Adult-Onset Microsatellite Stable Colorectal Cancer Patients.
Sukhokanjanachusak K, Pongpaibul A, Nimmannit A, Akewanlop C, Korphaisarn K
J Adolesc Young Adult Oncol 2021 Oct;10(5):573-580. Epub 2020 Oct 20 doi: 10.1089/jayao.2020.0144. PMID: 33085547
Colorectal tumor molecular phenotype and miRNA: expression profiles and prognosis.
Slattery ML, Herrick JS, Mullany LE, Wolff E, Hoffman MD, Pellatt DF, Stevens JR, Wolff RK
Mod Pathol 2016 Aug;29(8):915-27. Epub 2016 May 20 doi: 10.1038/modpathol.2016.73. PMID: 27198570Free PMC Article
The serrated pathway to colorectal carcinoma: current concepts and challenges.
Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V
Histopathology 2013 Feb;62(3):367-86. doi: 10.1111/his.12055. PMID: 23339363

Clinical prediction guides

Microsatellite instability in colon cancer: A single center experience from North India.
Arora S, Adhikari N, Rathi AK, Singh K, Sakhuja P
J Cancer Res Ther 2022 Apr-Jun;18(3):656-660. doi: 10.4103/jcrt.jcrt_423_21. PMID: 35900537
Presence of Tim3(+) and PD-1(+) CD8(+) T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features.
Klapholz M, Drage MG, Srivastava A, Anderson AC
J Pathol 2022 Jun;257(2):186-197. Epub 2022 Apr 9 doi: 10.1002/path.5877. PMID: 35119692
Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger.
de Voer RM, Diets IJ, van der Post RS, Weren RDA, Kamping EJ, de Bitter TJJ, Elze L, Verhoeven RHA, Vink-Börger E, Eijkelenboom A, Mensenkamp A, Nagtegaal ID, Jongmans MCJ, Ligtenberg MJL
Clin Gastroenterol Hepatol 2021 Aug;19(8):1642-1651.e8. Epub 2020 Jun 22 doi: 10.1016/j.cgh.2020.06.034. PMID: 32585361
Gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC): An immunohistochemistry study of 13 microsatellite stable cases.
Gurzu S, Fetyko A, Bara T, Banias L, Butiurca VO, Bara T Jr, Tudorache V, Jung I
Pathol Res Pract 2019 Dec;215(12):152697. Epub 2019 Oct 23 doi: 10.1016/j.prp.2019.152697. PMID: 31704155
Transcriptional profiles underpin microsatellite status and associated features in colon cancer.
Hogan J, DeJulius K, Liu X, Coffey JC, Kalady MF
Gene 2015 Oct 1;570(1):36-43. Epub 2015 Feb 20 doi: 10.1016/j.gene.2015.02.057. PMID: 25704535

Recent systematic reviews

Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review.
Nejadtaghi M, Jafari H, Farrokhi E, Samani KG
Curr Probl Cancer 2017 Nov-Dec;41(6):388-397. Epub 2017 Oct 18 doi: 10.1016/j.currproblcancer.2017.10.002. PMID: 29096939

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