TFCP2 Gene Rearrangement

MedGen UID:: 1791330
•Concept ID:: C5554889
•: Cell or Molecular Dysfunction

Synonyms:

LSF Gene Rearrangement; SEF Gene Rearrangement; Transcription Factor CP2 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the TFCP2 gene. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTFCP2 Gene Rearrangement

Molecular Abnormality
- Cytogenetic Abnormality
  - Chromosome 12 Abnormality
    - TFCP2 Gene Rearrangement

Recent clinical studies

Etiology

Intraosseous Spindle Cell/Epithelioid Rhabdomyosarcoma with TFCP2 Rearrangement: A Recent Recognized Subtype with Partial Response to Alectinib.

Valério E, Furtado Costa JL, Perez Fraile NM, Credidio CH, Taveira Garcia MR, Neto CS, Costa FD
Int J Surg Pathol 2023 Aug;31(5):861-865. Epub 2022 Dec 6 doi: 10.1177/10668969221140397. PMID: 36474403

Expanding the Spectrum of Intraosseous Rhabdomyosarcoma: Correlation Between 2 Distinct Gene Fusions and Phenotype.

Agaram NP, Zhang L, Sung YS, Cavalcanti MS, Torrence D, Wexler L, Francis G, Sommerville S, Swanson D, Dickson BC, Suurmeijer AJH, Williamson R, Antonescu CR
Am J Surg Pathol 2019 May;43(5):695-702. doi: 10.1097/PAS.0000000000001227. PMID: 30720533 Free PMC Article

See all (2)

Diagnosis

Intraosseous Spindle Cell/Epithelioid Rhabdomyosarcoma with TFCP2 Rearrangement: A Recent Recognized Subtype with Partial Response to Alectinib.

Rhabdomyosarcoma With FUS::TFCP2 Fusion in the Scalp: A Rare Case Report Depicting Round and Spindle cell Morphology.

Ishiyama T, Kato I, Ito J, Matsumura M, Saito K, Kawabata Y, Kato S, Takeyama M, Fujii S
Int J Surg Pathol 2023 Aug;31(5):805-812. Epub 2022 Nov 27 doi: 10.1177/10668969221137517. PMID: 36437645

Clinicopathological features of rhabdomyosarcoma with novel FET::TFCP2 and TIMP3::ALK fusion: report of two cases and literature review.

Duan FL, Yang H, Gong X, Zuo Z, Qin S, Ji J, Zhou C, Dai J, Guo P, Liu Y
Histopathology 2023 Feb;82(3):478-484. Epub 2022 Nov 21 doi: 10.1111/his.14833. PMID: 36350070

Epithelioid and Spindle Cell Rhabdomyosarcoma of the Oral Mucosa with FUS Rearrangement.

Ochsner AR, Foss RD
Head Neck Pathol 2022 Sep;16(3):823-827. Epub 2022 Mar 30 doi: 10.1007/s12105-022-01424-x. PMID: 35353344 Free PMC Article

Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall.

Kerr DA, Thompson LDR, Tafe LJ, Jo VY, Neyaz A, Divakar P, Paydarfar JA, Pastel DA, Shirai K, John I, Seethala RR, Salgado CM, Deshpande V, Bridge JA, Kashofer K, Brčić I, Linos K
Am J Surg Pathol 2021 Dec 1;45(12):1707-1719. doi: 10.1097/PAS.0000000000001735. PMID: 34001695

See all (5)

Prognosis

Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis.

Li Y, Li D, Wang J, Tang J
Diagn Pathol 2023 Mar 30;18(1):41. doi: 10.1186/s13000-023-01330-y. PMID: 36998041 Free PMC Article

Clinicopathological features of rhabdomyosarcoma with novel FET::TFCP2 and TIMP3::ALK fusion: report of two cases and literature review.

Duan FL, Yang H, Gong X, Zuo Z, Qin S, Ji J, Zhou C, Dai J, Guo P, Liu Y
Histopathology 2023 Feb;82(3):478-484. Epub 2022 Nov 21 doi: 10.1111/his.14833. PMID: 36350070

Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall.

See all (3)

Clinical prediction guides

Clinicopathological features of rhabdomyosarcoma with novel FET::TFCP2 and TIMP3::ALK fusion: report of two cases and literature review.

Duan FL, Yang H, Gong X, Zuo Z, Qin S, Ji J, Zhou C, Dai J, Guo P, Liu Y
Histopathology 2023 Feb;82(3):478-484. Epub 2022 Nov 21 doi: 10.1111/his.14833. PMID: 36350070

Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall.

See all (2)