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FN1 Gene Rearrangement

MedGen UID:
1791334
•Concept ID:
C5554893
•
Cell or Molecular Dysfunction
Synonyms: CIG Gene Rearrangement; Fibronectin 1 Gene Rearrangement; Fibronectin Gene Rearrangement; FINC Gene Rearrangement; FN Gene Rearrangement; FNZ Gene Rearrangement; LETS Gene Rearrangement; MSF Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the FN1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFN1 Gene Rearrangement

Recent clinical studies

Etiology

Klotho Overexpression Is Frequently Associated With Upstream Rearrangements in Fusion-Negative Phosphaturic Mesenchymal Tumors of Bone and Sinonasal Tract.
Lee JC, Hsieh TH, Kao YC, Tsai CF, Huang HY, Shih CY, Song HL, Oda Y, Chih-Hsueh Chen P, Pan CC, Sittampalam K, Petersson F, Konishi E, Chiu WY, Chen CF, Carpenter TO, Lu TP, Chang CD, Huang SC, Folpe AL
Mod Pathol 2023 Dec;36(12):100336. Epub 2023 Sep 22 doi: 10.1016/j.modpat.2023.100336. PMID: 37742927
Comparative genomic hybridization, BRAF, RAS, RET, and oligo-array analysis in aneuploid papillary thyroid carcinomas.
Rodrigues R, Roque L, Espadinha C, Pinto A, Domingues R, Dinis J, Catarino A, Pereira T, Leite V
Oncol Rep 2007 Oct;18(4):917-26. PMID: 17786355

Diagnosis

'I Can't Keep Up!': an update on advances in soft tissue pathology occurring after the publication of the 2020 World Health Organization classification of soft tissue and bone tumours.
Folpe AL
Histopathology 2022 Jan;80(1):54-75. doi: 10.1111/his.14460. PMID: 34958510
Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases.
Lopez-Nunez O, John I, Panasiti RN, Ranganathan S, Santoro L, Grélaud D, Wu T, Buccoliero AM, Casanova M, Alaggio R, Surrey LF
Mod Pathol 2020 Apr;33(4):576-590. Epub 2019 Nov 5 doi: 10.1038/s41379-019-0406-6. PMID: 31690781
A molecular study of synovial chondromatosis.
Agaram NP, Zhang L, Dickson BC, Swanson D, Sung YS, Panicek DM, Hameed M, Healey JH, Antonescu CR
Genes Chromosomes Cancer 2020 Mar;59(3):144-151. Epub 2019 Oct 18 doi: 10.1002/gcc.22812. PMID: 31589790Free PMC Article
Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.
Haimes JD, Stewart CJR, Kudlow BA, Culver BP, Meng B, Koay E, Whitehouse A, Cope N, Lee JC, Ng T, McCluggage WG, Lee CH
Am J Surg Pathol 2017 Jun;41(6):773-780. doi: 10.1097/PAS.0000000000000801. PMID: 28490045
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article

Therapy

Inflammatory Myofibroblastic Tumor of the Bladder With FN1-ALK Gene Fusion: Different Response to ALK Inhibition.
Reinhart S, Trachsel Y, Fritz C, Wagner U, Bode-Lesniewska B, John H, Pless M
Urology 2020 Dec;146:32-35. Epub 2020 Sep 30 doi: 10.1016/j.urology.2020.09.026. PMID: 33007314
Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases.
Lopez-Nunez O, John I, Panasiti RN, Ranganathan S, Santoro L, Grélaud D, Wu T, Buccoliero AM, Casanova M, Alaggio R, Surrey LF
Mod Pathol 2020 Apr;33(4):576-590. Epub 2019 Nov 5 doi: 10.1038/s41379-019-0406-6. PMID: 31690781
Comparative genomic hybridization, BRAF, RAS, RET, and oligo-array analysis in aneuploid papillary thyroid carcinomas.
Rodrigues R, Roque L, Espadinha C, Pinto A, Domingues R, Dinis J, Catarino A, Pereira T, Leite V
Oncol Rep 2007 Oct;18(4):917-26. PMID: 17786355

Prognosis

Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article
Proteomic analysis of human osteoblastic cells: relevant proteins and functional categories for differentiation.
Alves RD, Eijken M, Swagemakers S, Chiba H, Titulaer MK, Burgers PC, Luider TM, van Leeuwen JP
J Proteome Res 2010 Sep 3;9(9):4688-700. doi: 10.1021/pr100400d. PMID: 20690663
Comparative genomic hybridization, BRAF, RAS, RET, and oligo-array analysis in aneuploid papillary thyroid carcinomas.
Rodrigues R, Roque L, Espadinha C, Pinto A, Domingues R, Dinis J, Catarino A, Pereira T, Leite V
Oncol Rep 2007 Oct;18(4):917-26. PMID: 17786355

Clinical prediction guides

Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.
Amary F, Perez-Casanova L, Ye H, Cottone L, Strobl AC, Cool P, Miranda E, Berisha F, Aston W, Rocha M, O'Donnell P, Pillay N, Tirabosco R, Baumhoer D, Hookway ES, Flanagan AM
Mod Pathol 2019 Dec;32(12):1762-1771. Epub 2019 Jul 4 doi: 10.1038/s41379-019-0315-8. PMID: 31273315Free PMC Article
Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant.
Yamada Y, Kinoshita I, Kenichi K, Yamamoto H, Iwasaki T, Otsuka H, Yoshimoto M, Ishihara S, Toda Y, Kuma Y, Setsu N, Koga Y, Honda Y, Inoue T, Yanai H, Yamashita K, Ito I, Takahashi M, Ohga S, Furue M, Nakashima Y, Oda Y
Histopathology 2018 Feb;72(3):460-471. Epub 2017 Nov 16 doi: 10.1111/his.13377. PMID: 28858396
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article

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