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Genetic Predisposition to Leukemia

MedGen UID:
1791434
•Concept ID:
C5554993
•
Finding

Definition

The predisposition of an individual to develop leukemia based on their heredity. [from NCI]

Professional guidelines

PubMed

Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Śliwa-Tytko P, Kaczmarska A, Lejman M, Zawitkowska J
Int J Mol Sci 2022 May 15;23(10) doi: 10.3390/ijms23105515. PMID: 35628334Free PMC Article
Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management.
Rausch CR, Jabbour EJ, Kantarjian HM, Kadia TM
Cancer 2020 Mar 15;126(6):1152-1160. Epub 2019 Dec 3 doi: 10.1002/cncr.32606. PMID: 31794095
Leukemia: an overview for primary care.
Davis AS, Viera AJ, Mead MD
Am Fam Physician 2014 May 1;89(9):731-8. PMID: 24784336

Recent clinical studies

Therapy

Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
Myelodysplastic Syndromes.
Cazzola M
N Engl J Med 2020 Oct 1;383(14):1358-1374. doi: 10.1056/NEJMra1904794. PMID: 32997910
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Leukemia: an overview for primary care.
Davis AS, Viera AJ, Mead MD
Am Fam Physician 2014 May 1;89(9):731-8. PMID: 24784336
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Prognosis

NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA
Cold Spring Harb Perspect Med 2017 Feb 1;7(2) doi: 10.1101/cshperspect.a030320. PMID: 28003281Free PMC Article
Leukemia.
Juliusson G, Hough R
Prog Tumor Res 2016;43:87-100. Epub 2016 Sep 5 doi: 10.1159/000447076. PMID: 27595359
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Clinical prediction guides

Updates on targeted therapies for acute myeloid leukaemia.
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article

Recent systematic reviews

Relationship between non-syndromic oral clefts and cancer: A systematic review and meta-analysis.
Machado RA, Popoff DAV, Martelli-Júnior H
Oral Dis 2022 Jul;28(5):1369-1386. Epub 2022 Mar 22 doi: 10.1111/odi.14179. PMID: 35258156
IKZF1 Rs4132601 Polymorphism and Susceptibility to Acute Lymphocytic Leukemia in Children: A Meta-analysis.
Wu X, Liu M, Wang Q
J Pediatr Hematol Oncol 2022 Jan 1;44(1):e101-e108. doi: 10.1097/MPH.0000000000002130. PMID: 33661176
Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis.
Zining J, Lu X, Caiyun H, Yuan Y
Oncotarget 2016 Aug 30;7(35):57464-57480. doi: 10.18632/oncotarget.10805. PMID: 27462867Free PMC Article
The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.
Jiang D, Hong Q, Shen Y, Xu Y, Zhu H, Li Y, Xu C, Ouyang G, Duan S
PLoS One 2014;9(5):e96822. Epub 2014 May 8 doi: 10.1371/journal.pone.0096822. PMID: 24810788Free PMC Article
Spectrum and risk of neoplasia in Werner syndrome: a systematic review.
Lauper JM, Krause A, Vaughan TL, Monnat RJ Jr
PLoS One 2013;8(4):e59709. Epub 2013 Apr 1 doi: 10.1371/journal.pone.0059709. PMID: 23573208Free PMC Article

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