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Mucosal Melanoma of the Female Genital Tract

MedGen UID:
1791473
•Concept ID:
C5555032
•
Neoplastic Process

Definition

A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucosal Melanoma of the Female Genital Tract

Professional guidelines

PubMed

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Management and treatment of mucosal melanoma of the genital tract.
Vaccari S, Barisani A, Dika E, Fanti PA, DE Iaco P, Gurioli C, Tosti G
G Ital Dermatol Venereol 2017 Jun;152(3):270-273. Epub 2017 Jan 24 doi: 10.23736/S0392-0488.17.05573-0. PMID: 28121085
Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205

Recent clinical studies

Etiology

Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Predictors of mucosal melanoma survival in a population-based setting.
Altieri L, Eguchi M, Peng DH, Cockburn M
J Am Acad Dermatol 2019 Jul;81(1):136-142.e2. Epub 2018 Oct 5 doi: 10.1016/j.jaad.2018.09.054. PMID: 30296542Free PMC Article
Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.
Yélamos O, Merkel EA, Sholl LM, Zhang B, Amin SM, Lee CY, Guitart GE, Yang J, Wenzel AT, Bunick CG, Yazdan P, Choi J, Gerami P
J Invest Dermatol 2016 Sep;136(9):1858-1865. Epub 2016 May 21 doi: 10.1016/j.jid.2016.05.094. PMID: 27220476Free PMC Article
Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Diagnosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Management and treatment of mucosal melanoma of the genital tract.
Vaccari S, Barisani A, Dika E, Fanti PA, DE Iaco P, Gurioli C, Tosti G
G Ital Dermatol Venereol 2017 Jun;152(3):270-273. Epub 2017 Jan 24 doi: 10.23736/S0392-0488.17.05573-0. PMID: 28121085
Management of primary melanoma of the female urogenital tract.
Piura B
Lancet Oncol 2008 Oct;9(10):973-81. doi: 10.1016/S1470-2045(08)70254-7. PMID: 19071254
Primary mucosal melanoma.
Patrick RJ, Fenske NA, Messina JL
J Am Acad Dermatol 2007 May;56(5):828-34. Epub 2007 Mar 8 doi: 10.1016/j.jaad.2006.06.017. PMID: 17349716
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Therapy

Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma.
Heppt MV, Roesch A, Weide B, Gutzmer R, Meier F, Loquai C, Kähler KC, Gesierich A, Meissner M, von Bubnoff D, Göppner D, Schlaak M, Pföhler C, Utikal J, Heinzerling L, Cosgarea I, Engel J, Eckel R, Martens A, Mirlach L, Satzger I, Schubert-Fritschle G, Tietze JK, Berking C
Eur J Cancer 2017 Aug;81:36-44. Epub 2017 Jun 7 doi: 10.1016/j.ejca.2017.05.014. PMID: 28600969
Clinics, prognosis and new therapeutic options in patients with mucosal melanoma: A retrospective analysis of 75 patients.
Schaefer T, Satzger I, Gutzmer R
Medicine (Baltimore) 2017 Jan;96(1):e5753. doi: 10.1097/MD.0000000000005753. PMID: 28072717Free PMC Article
Primary malignant melanoma of the female genital tract.
Gungor T, Altinkaya SO, Ozat M, Bayramoglu H, Mollamahmutoglu L
Taiwan J Obstet Gynecol 2009 Jun;48(2):169-75. doi: 10.1016/S1028-4559(09)60281-3. PMID: 19574182
Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy.
McGuire SE, Frank SJ, Eifel PJ
Brachytherapy 2008 Oct-Dec;7(4):359-63. Epub 2008 Sep 7 doi: 10.1016/j.brachy.2008.04.005. PMID: 18778972

Prognosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205
Mucosal melanoma: a clinically and biologically unique disease entity.
Carvajal RD, Spencer SA, Lydiatt W
J Natl Compr Canc Netw 2012 Mar;10(3):345-56. doi: 10.6004/jnccn.2012.0034. PMID: 22393195
Primary mucosal melanoma.
Patrick RJ, Fenske NA, Messina JL
J Am Acad Dermatol 2007 May;56(5):828-34. Epub 2007 Mar 8 doi: 10.1016/j.jaad.2006.06.017. PMID: 17349716
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Clinical prediction guides

Management of Clitoral Melanoma Presenting as an Exophytic Clitoral Mass: A Case Report and Review of the Literature.
Szlachta-McGinn A, Chmielowski B, Kang Y, Raman S, Memarzadeh S
Curr Oncol 2021 Oct 21;28(6):4264-4272. doi: 10.3390/curroncol28060362. PMID: 34898540Free PMC Article
Predictors of mucosal melanoma survival in a population-based setting.
Altieri L, Eguchi M, Peng DH, Cockburn M
J Am Acad Dermatol 2019 Jul;81(1):136-142.e2. Epub 2018 Oct 5 doi: 10.1016/j.jaad.2018.09.054. PMID: 30296542Free PMC Article
Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma.
Heppt MV, Roesch A, Weide B, Gutzmer R, Meier F, Loquai C, Kähler KC, Gesierich A, Meissner M, von Bubnoff D, Göppner D, Schlaak M, Pföhler C, Utikal J, Heinzerling L, Cosgarea I, Engel J, Eckel R, Martens A, Mirlach L, Satzger I, Schubert-Fritschle G, Tietze JK, Berking C
Eur J Cancer 2017 Aug;81:36-44. Epub 2017 Jun 7 doi: 10.1016/j.ejca.2017.05.014. PMID: 28600969
KIT pathway alterations in mucosal melanomas of the vulva and other sites.
Omholt K, Grafström E, Kanter-Lewensohn L, Hansson J, Ragnarsson-Olding BK
Clin Cancer Res 2011 Jun 15;17(12):3933-42. doi: 10.1158/1078-0432.CCR-10-2917. PMID: 21680547
Vulvar melanoma: a report of 10 cases and review of the literature.
De Simone P, Silipo V, Buccini P, Mariani G, Marenda S, Eibenschutz L, Ferrari A, Catricalà C
Melanoma Res 2008 Apr;18(2):127-33. doi: 10.1097/CMR.0b013e3282f94636. PMID: 18337649

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