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Secondary Peripheral Chondrosarcoma, Grade 1

MedGen UID:
1791512
•Concept ID:
C5555071
•
Neoplastic Process
Synonym: Peripheral Chondrosarcoma, Grade 1

Definition

A locally aggressive, low-grade chondrosarcoma arising within the cartilaginous cap of a pre-existing osteochondroma in the axial skeleton. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Peripheral Chondrosarcoma, Grade 1

Professional guidelines

PubMed

Pelvic chondrosarcomas: surgical treatment options.
Deloin X, Dumaine V, Biau D, Karoubi M, Babinet A, Tomeno B, Anract P
Orthop Traumatol Surg Res 2009 Oct;95(6):393-401. Epub 2009 Oct 3 doi: 10.1016/j.otsr.2009.05.004. PMID: 19801212

Recent clinical studies

Etiology

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
Is the Width of a Surgical Margin Associated with the Outcome of Disease in Patients with Peripheral Chondrosarcoma of the Pelvis? A Multicenter Study.
Tsuda Y, Evans S, Stevenson JD, Parry M, Fujiwara T, Laitinen M, Outani H, Jeys L
Clin Orthop Relat Res 2019 Nov;477(11):2432-2440. doi: 10.1097/CORR.0000000000000926. PMID: 31453886Free PMC Article
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Goud AL, Wuyts W, Bessems J, Bramer J, van der Woude HJ, Ham J
J Bone Joint Surg Am 2015 Jan 7;97(1):24-31. doi: 10.2106/JBJS.N.00121. PMID: 25568391
Survival analysis of patients with chondrosarcomas of the pelvis.
Mavrogenis AF, Angelini A, Drago G, Merlino B, Ruggieri P
J Surg Oncol 2013 Jul;108(1):19-27. Epub 2013 May 16 doi: 10.1002/jso.23351. PMID: 23681650

Diagnosis

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Conventional chondrosarcoma of the rib cage and sternum: clinicopathological and molecular analysis of 27 patients treated at a single institution.
Abdulfatah E, Rottmann D, Morag Y, Pantanowitz L, Udager AM, Hao W, Lucas DR
Hum Pathol 2023 Jun;136:63-74. Epub 2023 Apr 3 doi: 10.1016/j.humpath.2023.03.011. PMID: 37019410
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Goud AL, Wuyts W, Bessems J, Bramer J, van der Woude HJ, Ham J
J Bone Joint Surg Am 2015 Jan 7;97(1):24-31. doi: 10.2106/JBJS.N.00121. PMID: 25568391
Survival analysis of patients with chondrosarcomas of the pelvis.
Mavrogenis AF, Angelini A, Drago G, Merlino B, Ruggieri P
J Surg Oncol 2013 Jul;108(1):19-27. Epub 2013 May 16 doi: 10.1002/jso.23351. PMID: 23681650

Therapy

Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma.
Dickson MA, Mahoney MR, Tap WD, D'Angelo SP, Keohan ML, Van Tine BA, Agulnik M, Horvath LE, Nair JS, Schwartz GK
Ann Oncol 2016 Oct;27(10):1855-60. Epub 2016 Aug 8 doi: 10.1093/annonc/mdw281. PMID: 27502708Free PMC Article

Prognosis

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series.
Gnoli M, Gambarotti M, Righi A, Staals EL, Evangelista A, Tremosini M, Brizola E, Mordenti M, Boarini M, Locatelli M, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2024 Feb 13;19(1):63. doi: 10.1186/s13023-023-03006-8. PMID: 38351015Free PMC Article
Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival.
Righi A, Pacheco M, Cocchi S, Asioli S, Gambarotti M, Donati DM, Evangelista A, Gnoli M, Locatelli M, Mordenti M, Boarini M, Brizola E, Pedrini E, Sangiorgi L
Orphanet J Rare Dis 2022 Feb 22;17(1):74. doi: 10.1186/s13023-022-02210-2. PMID: 35193636Free PMC Article
The diagnostic significance of pulmonary nodules on CT thorax in chondrosarcoma of bone.
McLoughlin E, Davies AM, Iqbal A, James SL, Botchu R
Clin Radiol 2020 May;75(5):395.e7-395.e16. Epub 2019 Dec 31 doi: 10.1016/j.crad.2019.11.017. PMID: 31898960
Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort.
Thorkildsen J, Taksdal I, Bjerkehagen B, Haugland HK, Børge Johannesen T, Viset T, Norum OJ, Bruland Ø, Zaikova O
Acta Oncol 2019 Mar;58(3):273-282. Epub 2019 Jan 11 doi: 10.1080/0284186X.2018.1554260. PMID: 30632866
Pelvic chondrosarcomas: surgical treatment options.
Deloin X, Dumaine V, Biau D, Karoubi M, Babinet A, Tomeno B, Anract P
Orthop Traumatol Surg Res 2009 Oct;95(6):393-401. Epub 2009 Oct 3 doi: 10.1016/j.otsr.2009.05.004. PMID: 19801212

Clinical prediction guides

The diagnostic significance of pulmonary nodules on CT thorax in chondrosarcoma of bone.
McLoughlin E, Davies AM, Iqbal A, James SL, Botchu R
Clin Radiol 2020 May;75(5):395.e7-395.e16. Epub 2019 Dec 31 doi: 10.1016/j.crad.2019.11.017. PMID: 31898960
Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort.
Thorkildsen J, Taksdal I, Bjerkehagen B, Haugland HK, Børge Johannesen T, Viset T, Norum OJ, Bruland Ø, Zaikova O
Acta Oncol 2019 Mar;58(3):273-282. Epub 2019 Jan 11 doi: 10.1080/0284186X.2018.1554260. PMID: 30632866
Survival analysis of patients with chondrosarcomas of the pelvis.
Mavrogenis AF, Angelini A, Drago G, Merlino B, Ruggieri P
J Surg Oncol 2013 Jul;108(1):19-27. Epub 2013 May 16 doi: 10.1002/jso.23351. PMID: 23681650
Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four cases.
Franchi A, Baroni G, Sardi I, Giunti L, Capanna R, Campanacci D
Virchows Arch 2012 Mar;460(3):335-42. Epub 2012 Feb 16 doi: 10.1007/s00428-012-1206-2. PMID: 22350005
Dedifferentiated peripheral chondrosarcomas: regulation of EXT-downstream molecules and differentiation-related genes.
Rozeman LB, de Bruijn IH, Bacchini P, Staals EL, Bertoni F, Bovée JV, Hogendoorn PC
Mod Pathol 2009 Nov;22(11):1489-98. Epub 2009 Sep 4 doi: 10.1038/modpathol.2009.120. PMID: 19734846

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