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Yolk Sac Tumor with Somatic-Type Malignancy

MedGen UID:
1791547
•Concept ID:
C5555106
•
Neoplastic Process

Definition

A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYolk Sac Tumor with Somatic-Type Malignancy

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors.
Acosta AM, Al-Obaidy KI, Sholl LM, Dickson BC, Lindeman NI, Hirsch MS, Collins K, Fletcher CD, Idrees MT
Am J Surg Pathol 2022 May 1;46(5):701-712. doi: 10.1097/PAS.0000000000001865. PMID: 35034041
Fluorescent In Situ Hybridization Analysis for 12p Alterations in Sarcomatoid Yolk Sac Tumors.
Idrees MT, Ulbright TM, Epstein JI
Am J Surg Pathol 2019 Nov;43(11):1566-1573. doi: 10.1097/PAS.0000000000001354. PMID: 31478941
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330

Diagnosis

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Reprint of: somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2023 Mar;133:102-114. Epub 2023 Mar 6 doi: 10.1016/j.humpath.2023.02.008. PMID: 36890027
Somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2022 Sep;127:123-135. Epub 2022 Jul 5 doi: 10.1016/j.humpath.2022.06.024. PMID: 35803413
Somatic-Type Yolk Sac Tumor Arising as a Predominant Component of Bladder Urothelial Carcinoma.
Collins K, Alkashash AM, Hwang M, Kaimakliotis HZ, Cheng L, Idrees MT
Int J Surg Pathol 2022 Apr;30(2):207-213. Epub 2021 Jul 13 doi: 10.1177/10668969211030688. PMID: 34255554
Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features.
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275

Therapy

Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case.
Garg A, Nahal A, Turcotte R, Tabah R, Alcindor T
Tumori 2013 Jan-Feb;99(1):e24-7. doi: 10.1177/030089161309900128. PMID: 23549017

Prognosis

Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets.
Bremmer F, Pongratanakul P, Skowron M, Che Y, Richter A, Küffer S, Reuter-Jessen K, Bohnenberger H, Pauls S, Kresbach C, Schüller U, Stühler K, Ströbel P, Albers P, Nettersheim D
Br J Cancer 2023 Nov;129(10):1580-1589. Epub 2023 Sep 19 doi: 10.1038/s41416-023-02425-5. PMID: 37726478Free PMC Article
Reprint of: somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2023 Mar;133:102-114. Epub 2023 Mar 6 doi: 10.1016/j.humpath.2023.02.008. PMID: 36890027
Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
Somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2022 Sep;127:123-135. Epub 2022 Jul 5 doi: 10.1016/j.humpath.2022.06.024. PMID: 35803413
Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors.
Acosta AM, Al-Obaidy KI, Sholl LM, Dickson BC, Lindeman NI, Hirsch MS, Collins K, Fletcher CD, Idrees MT
Am J Surg Pathol 2022 May 1;46(5):701-712. doi: 10.1097/PAS.0000000000001865. PMID: 35034041

Clinical prediction guides

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report.
Lee YL, Lai CR, Yen MS
J Ovarian Res 2019 Jan 10;12(1):2. doi: 10.1186/s13048-018-0476-y. PMID: 30630520Free PMC Article
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
"Somatic-type" malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin.
Magers MJ, Kao CS, Cole CD, Rice KR, Foster RS, Einhorn LH, Ulbright TM
Am J Surg Pathol 2014 Oct;38(10):1396-409. doi: 10.1097/PAS.0000000000000262. PMID: 24921638

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