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FOS Gene Rearrangement

MedGen UID:
1791571
•Concept ID:
C5555130
•
Cell or Molecular Dysfunction
Synonyms: c-Fos Gene Rearrangement; Fos Proto-Oncogene, AP-1 Transcription Factor Subunit Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the FOS gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFOS Gene Rearrangement

Professional guidelines

PubMed

miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease.
Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E, Botta C, Paolino FM, Del Giudice T, Iuliano E, Caraglia M, Ferrarini M, Giordano A, Tagliaferri P, Tassone P
J Cell Physiol 2013 Jul;228(7):1506-15. doi: 10.1002/jcp.24306. PMID: 23254643
Genotype markers and proto-oncogene analysis in the CD30-positive "malignant histiocytosis" DEL cell line with t(5;6)(q35;p21).
Gogusev J, Barbey S, Nezelof C
Int J Cancer 1990 Jul 15;46(1):106-12. doi: 10.1002/ijc.2910460120. PMID: 2163988

Recent clinical studies

Diagnosis

Epithelioid osteoblastoma with secondary aneurysmal bone cyst and FOS gene rearrangement.
Snow JT, Edgar MA, Halphen CR, Stanborough RO, Garner HW
Skeletal Radiol 2022 Mar;51(3):673-679. Epub 2021 Aug 26 doi: 10.1007/s00256-021-03895-5. PMID: 34448010
Benign Bone-Forming Tumors.
Amary F, Flanagan AM, O'Donnell P
Surg Pathol Clin 2021 Dec;14(4):549-565. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.002. PMID: 34742480
FOS Expression in Osteoid Osteoma and Osteoblastoma: A Valuable Ancillary Diagnostic Tool.
Amary F, Markert E, Berisha F, Ye H, Gerrand C, Cool P, Tirabosco R, Lindsay D, Pillay N, O'Donnell P, Baumhoer D, Flanagan AM
Am J Surg Pathol 2019 Dec;43(12):1661-1667. doi: 10.1097/PAS.0000000000001355. PMID: 31490237

Prognosis

FOS Expression in Osteoid Osteoma and Osteoblastoma: A Valuable Ancillary Diagnostic Tool.
Amary F, Markert E, Berisha F, Ye H, Gerrand C, Cool P, Tirabosco R, Lindsay D, Pillay N, O'Donnell P, Baumhoer D, Flanagan AM
Am J Surg Pathol 2019 Dec;43(12):1661-1667. doi: 10.1097/PAS.0000000000001355. PMID: 31490237

Clinical prediction guides

FOS Expression in Osteoid Osteoma and Osteoblastoma: A Valuable Ancillary Diagnostic Tool.
Amary F, Markert E, Berisha F, Ye H, Gerrand C, Cool P, Tirabosco R, Lindsay D, Pillay N, O'Donnell P, Baumhoer D, Flanagan AM
Am J Surg Pathol 2019 Dec;43(12):1661-1667. doi: 10.1097/PAS.0000000000001355. PMID: 31490237

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