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Cancer-Associated Anorexia

MedGen UID:
1791963
•Concept ID:
C5555522
•
Disease or Syndrome

Definition

Loss of appetite associated with cancer or its treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCancer-Associated Anorexia

Professional guidelines

PubMed

An overview of anamorelin as a treatment option for cancer-associated anorexia and cachexia.
Fonseca GWPD, von Haehling S
Expert Opin Pharmacother 2021 May;22(7):889-895. Epub 2021 Jan 25 doi: 10.1080/14656566.2021.1873954. PMID: 33491505
The management strategies of cancer-associated anorexia: a critical appraisal of systematic reviews.
Zhang F, Shen A, Jin Y, Qiang W
BMC Complement Altern Med 2018 Aug 9;18(1):236. doi: 10.1186/s12906-018-2304-8. PMID: 30092794Free PMC Article
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article

Recent clinical studies

Etiology

Cancer-associated anorexia: Validity and performance overtime of different appetite tools among patients at their first cancer diagnosis.
Molfino A, de van der Schueren MAE, Sánchez-Lara K, Milke P, Amabile MI, Imbimbo G, Di Lazzaro L, Cavuto S, Ronzani G, Snegovoy A, Gioulbasanis I, Laviano A
Clin Nutr 2021 Jun;40(6):4037-4042. Epub 2021 Feb 23 doi: 10.1016/j.clnu.2021.02.016. PMID: 33676774
The management strategies of cancer-associated anorexia: a critical appraisal of systematic reviews.
Zhang F, Shen A, Jin Y, Qiang W
BMC Complement Altern Med 2018 Aug 9;18(1):236. doi: 10.1186/s12906-018-2304-8. PMID: 30092794Free PMC Article
Systematic review and meta-analysis of cannabinoids in palliative medicine.
Mücke M, Weier M, Carter C, Copeland J, Degenhardt L, Cuhls H, Radbruch L, Häuser W, Conrad R
J Cachexia Sarcopenia Muscle 2018 Apr;9(2):220-234. Epub 2018 Feb 5 doi: 10.1002/jcsm.12273. PMID: 29400010Free PMC Article
Energy imbalance and cancer: Cause or consequence?
Wang X, Liu W, Xie X
IUBMB Life 2017 Oct;69(10):776-784. Epub 2017 Aug 31 doi: 10.1002/iub.1674. PMID: 28858429
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article

Diagnosis

Cancer-associated anorexia: Validity and performance overtime of different appetite tools among patients at their first cancer diagnosis.
Molfino A, de van der Schueren MAE, Sánchez-Lara K, Milke P, Amabile MI, Imbimbo G, Di Lazzaro L, Cavuto S, Ronzani G, Snegovoy A, Gioulbasanis I, Laviano A
Clin Nutr 2021 Jun;40(6):4037-4042. Epub 2021 Feb 23 doi: 10.1016/j.clnu.2021.02.016. PMID: 33676774
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article
The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.
Jatoi A, Qi Y, Kendall G, Jiang R, McNallan S, Cunningham J, Mandrekar S, Yang P
Support Care Cancer 2010 Oct;18(10):1299-304. Epub 2009 Dec 15 doi: 10.1007/s00520-009-0748-6. PMID: 20012999Free PMC Article
Megestrol acetate for the treatment of anorexia-cachexia syndrome.
Berenstein EG, Ortiz Z
Cochrane Database Syst Rev 2005 Apr 18;(2):CD004310. doi: 10.1002/14651858.CD004310.pub2. PMID: 15846706
Appetite and cancer-associated anorexia: a review.
Davis MP, Dreicer R, Walsh D, Lagman R, LeGrand SB
J Clin Oncol 2004 Apr 15;22(8):1510-7. doi: 10.1200/JCO.2004.03.103. PMID: 15084624

Therapy

Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial.
Hunter CN, Abdel-Aal HH, Elsherief WA, Farag DE, Riad NM, Alsirafy SA
J Pain Symptom Manage 2021 Dec;62(6):1207-1215. Epub 2021 May 26 doi: 10.1016/j.jpainsymman.2021.05.017. PMID: 34051293
A hunger for hunger: a review of palliative therapies for cancer-associated anorexia.
Childs DS, Jatoi A
Ann Palliat Med 2019 Jan;8(1):50-58. Epub 2018 May 24 doi: 10.21037/apm.2018.05.08. PMID: 29860861Free PMC Article
Systematic review and meta-analysis of cannabinoids in palliative medicine.
Mücke M, Weier M, Carter C, Copeland J, Degenhardt L, Cuhls H, Radbruch L, Häuser W, Conrad R
J Cachexia Sarcopenia Muscle 2018 Apr;9(2):220-234. Epub 2018 Feb 5 doi: 10.1002/jcsm.12273. PMID: 29400010Free PMC Article
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article
Cancer-associated anorexia and cachexia. Implications for drug therapy.
Loprinzi CL, Goldberg RM, Burnham NL
Drugs 1992 Apr;43(4):499-506. doi: 10.2165/00003495-199243040-00006. PMID: 1377116

Prognosis

A randomized, double-blind, placebo-controlled clinical trial of megestrol acetate as an appetite stimulant in children with weight loss due to cancer and/or cancer therapy.
Cuvelier GD, Baker TJ, Peddie EF, Casey LM, Lambert PJ, Distefano DS, Wardle MG, Mychajlunow BA, Romanick MA, Dix DB, Wilson BA
Pediatr Blood Cancer 2014 Apr;61(4):672-9. Epub 2013 Oct 26 doi: 10.1002/pbc.24828. PMID: 24167059
The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.
Jatoi A, Qi Y, Kendall G, Jiang R, McNallan S, Cunningham J, Mandrekar S, Yang P
Support Care Cancer 2010 Oct;18(10):1299-304. Epub 2009 Dec 15 doi: 10.1007/s00520-009-0748-6. PMID: 20012999Free PMC Article
Assessment of gastrointestinal function and response to megesterol acetate in subjects with gastrointestinal cancers and weight loss.
Deutsch J, Kolhouse JF
Support Care Cancer 2004 Jul;12(7):503-10. Epub 2004 Apr 3 doi: 10.1007/s00520-004-0615-4. PMID: 15064933
Current management of cancer-associated anorexia and weight loss.
Jatoi A Jr, Loprinzi CL
Oncology (Williston Park) 2001 Apr;15(4):497-502, 508; discussion 508-10. PMID: 11346935
Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia.
Loprinzi CL, Ellison NM, Schaid DJ, Krook JE, Athmann LM, Dose AM, Mailliard JA, Johnson PS, Ebbert LP, Geeraerts LH
J Natl Cancer Inst 1990 Jul 4;82(13):1127-32. doi: 10.1093/jnci/82.13.1127. PMID: 2193166

Clinical prediction guides

Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial.
Hunter CN, Abdel-Aal HH, Elsherief WA, Farag DE, Riad NM, Alsirafy SA
J Pain Symptom Manage 2021 Dec;62(6):1207-1215. Epub 2021 May 26 doi: 10.1016/j.jpainsymman.2021.05.017. PMID: 34051293
Cancer-associated anorexia: Validity and performance overtime of different appetite tools among patients at their first cancer diagnosis.
Molfino A, de van der Schueren MAE, Sánchez-Lara K, Milke P, Amabile MI, Imbimbo G, Di Lazzaro L, Cavuto S, Ronzani G, Snegovoy A, Gioulbasanis I, Laviano A
Clin Nutr 2021 Jun;40(6):4037-4042. Epub 2021 Feb 23 doi: 10.1016/j.clnu.2021.02.016. PMID: 33676774
An overview of anamorelin as a treatment option for cancer-associated anorexia and cachexia.
Fonseca GWPD, von Haehling S
Expert Opin Pharmacother 2021 May;22(7):889-895. Epub 2021 Jan 25 doi: 10.1080/14656566.2021.1873954. PMID: 33491505
The management strategies of cancer-associated anorexia: a critical appraisal of systematic reviews.
Zhang F, Shen A, Jin Y, Qiang W
BMC Complement Altern Med 2018 Aug 9;18(1):236. doi: 10.1186/s12906-018-2304-8. PMID: 30092794Free PMC Article
Current management of cancer-associated anorexia and weight loss.
Jatoi A Jr, Loprinzi CL
Oncology (Williston Park) 2001 Apr;15(4):497-502, 508; discussion 508-10. PMID: 11346935

Recent systematic reviews

Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/consensus guidance on the use of cannabinoids for gastrointestinal symptoms in patients with cancer.
Alderman B, Hui D, Mukhopadhyay S, Bouleuc C, Case AA, Amano K, Crawford GB, de Feo G, Sbrana A, Tanco K, To J, Garsed J, Davis M
Support Care Cancer 2022 Dec 16;31(1):39. doi: 10.1007/s00520-022-07480-x. PMID: 36525085
The management strategies of cancer-associated anorexia: a critical appraisal of systematic reviews.
Zhang F, Shen A, Jin Y, Qiang W
BMC Complement Altern Med 2018 Aug 9;18(1):236. doi: 10.1186/s12906-018-2304-8. PMID: 30092794Free PMC Article
Systematic review and meta-analysis of cannabinoids in palliative medicine.
Mücke M, Weier M, Carter C, Copeland J, Degenhardt L, Cuhls H, Radbruch L, Häuser W, Conrad R
J Cachexia Sarcopenia Muscle 2018 Apr;9(2):220-234. Epub 2018 Feb 5 doi: 10.1002/jcsm.12273. PMID: 29400010Free PMC Article
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article
Systematic review of the treatment of cancer-associated anorexia and weight loss.
Yavuzsen T, Davis MP, Walsh D, LeGrand S, Lagman R
J Clin Oncol 2005 Nov 20;23(33):8500-11. doi: 10.1200/JCO.2005.01.8010. PMID: 16293879

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