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Ovarian Dedifferentiated Carcinoma

MedGen UID:
1792061
•Concept ID:
C5555620
•
Neoplastic Process

Definition

An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by the presence of an undifferentiated carcinomatous component and a second component of either endometrioid carcinoma or, rarely, serous carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Dedifferentiated Carcinoma

Professional guidelines

PubMed

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Etiology

Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.
Kang EY, Tessier-Cloutier B, Duggan MA, Stewart CJR, Lee CH, Köbel M
Histopathology 2021 Aug;79(2):160-167. Epub 2021 Jun 2 doi: 10.1111/his.14333. PMID: 33432679
Undifferentiated and dedifferentiated neoplasms of the female genital tract.
Bennett JA, Oliva E
Semin Diagn Pathol 2021 Nov;38(6):137-151. Epub 2020 Nov 27 doi: 10.1053/j.semdp.2020.11.002. PMID: 33323288
Role of epithelial-mesenchymal transition factors in the histogenesis of uterine carcinomas.
Franceschi T, Durieux E, Morel AP, de Saint Hilaire P, Ray-Coquard I, Puisieux A, Devouassoux-Shisheboran M
Virchows Arch 2019 Jul;475(1):85-94. Epub 2019 Feb 9 doi: 10.1007/s00428-019-02532-w. PMID: 30739164
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Diagnosis

Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.
Kang EY, Tessier-Cloutier B, Duggan MA, Stewart CJR, Lee CH, Köbel M
Histopathology 2021 Aug;79(2):160-167. Epub 2021 Jun 2 doi: 10.1111/his.14333. PMID: 33432679
Undifferentiated and dedifferentiated neoplasms of the female genital tract.
Bennett JA, Oliva E
Semin Diagn Pathol 2021 Nov;38(6):137-151. Epub 2020 Nov 27 doi: 10.1053/j.semdp.2020.11.002. PMID: 33323288
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Therapy

The epithelial-mesenchymal transition and the estrogen-signaling in ovarian cancer.
Gallo D, Ferlini C, Scambia G
Curr Drug Targets 2010 Apr;11(4):474-81. doi: 10.2174/138945010790980385. PMID: 20015012
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Hasenburg A, Fischer DC, Tong XW, Rojas-Martinez A, Nyberg-Hoffman C, Orlowska-Volk M, Kohlberger P, Kaufman RH, Ramzy I, Aguilar-Cordova E, Kieback DG
Int J Gynecol Cancer 2002 Jan-Feb;12(1):66-73. doi: 10.1046/j.1525-1438.2002.01068.x. PMID: 11860538
Performance characteristics of the Indiana University Medical Center endometrial sampler (Tao Brush) in an outpatient office setting, first year's outcomes: recognizing histological patterns in cytology preparations of endometrial brushings.
Maksem JA
Diagn Cytopathol 2000 Mar;22(3):186-95. doi: 10.1002/(sici)1097-0339(20000301)22:3<186::aid-dc11>3.0.co;2-p. PMID: 10680001
Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma.
Tsuruchi N, Kaku T, Kinoshita H, Amada S, Saito T, Kamura T, Tsukamoto N, Nakano H
Gynecol Oncol 1993 Aug;50(2):259-63. doi: 10.1006/gyno.1993.1204. PMID: 8375741

Prognosis

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
The role of RhoC in ovarian epithelial carcinoma: a marker for carcinogenesis, progression, prognosis, and target therapy.
Zhao Y, Zheng HC, Chen S, Gou WF, Xiao LJ, Niu ZF
Gynecol Oncol 2013 Sep;130(3):570-8. Epub 2013 Jun 10 doi: 10.1016/j.ygyno.2013.06.004. PMID: 23764197
Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma.
Deng B, Zhao Y, Gou W, Chen S, Mao X, Takano Y, Zheng H
Tumour Biol 2013 Oct;34(5):2617-24. Epub 2013 May 9 doi: 10.1007/s13277-013-0811-2. PMID: 23657964Free PMC Article
Pteridines in the assessment of neoplasia.
Hausen A, Wachter H
J Clin Chem Clin Biochem 1982 Sep;20(9):593-602. doi: 10.1515/cclm.1982.20.9.593. PMID: 6754854

Clinical prediction guides

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.
Kang EY, Tessier-Cloutier B, Duggan MA, Stewart CJR, Lee CH, Köbel M
Histopathology 2021 Aug;79(2):160-167. Epub 2021 Jun 2 doi: 10.1111/his.14333. PMID: 33432679
A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype.
Rohnalter V, Roth K, Finkernagel F, Adhikary T, Obert J, Dorzweiler K, Bensberg M, Müller-Brüsselbach S, Müller R
Oncotarget 2015 Nov 24;6(37):40005-25. doi: 10.18632/oncotarget.5552. PMID: 26503466Free PMC Article
Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability.
Aysal A, Karnezis A, Medhi I, Grenert JP, Zaloudek CJ, Rabban JT
Am J Surg Pathol 2012 Feb;36(2):163-72. doi: 10.1097/PAS.0b013e31823bc434. PMID: 22189970
The epithelial-mesenchymal transition and the estrogen-signaling in ovarian cancer.
Gallo D, Ferlini C, Scambia G
Curr Drug Targets 2010 Apr;11(4):474-81. doi: 10.2174/138945010790980385. PMID: 20015012

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