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Giant Cell-Rich Osteosarcoma

MedGen UID:
1792108
Concept ID:
C5555667
Neoplastic Process

Definition

An exceedingly rare, high-grade variant of conventional osteosarcoma characterized by the presence of numerous osteoclast-like giant cells and variable amount of tumor osteoid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell-Rich Osteosarcoma

Professional guidelines

Recent clinical studies

Etiology

Suzuki H, Ikeda H, Nishida N, Funaba M, Fujimoto K, Iwanaga R, Sakai T
Anticancer Res 2023 Oct;43(10):4739-4745. doi: 10.21873/anticanres.16671. PMID: 37772568
Karczewski D, Gonzalez MR, Bedi A, Ready JE, Anderson ME, Lozano-Calderon SA
J Surg Oncol 2023 Oct;128(5):877-890. Epub 2023 Jun 9 doi: 10.1002/jso.27368. PMID: 37292033
Palmerini E, Seeger LL, Gambarotti M, Righi A, Reichardt P, Bukata S, Blay JY, Dai T, Jandial D, Picci P
BMC Cancer 2021 Jan 22;21(1):89. doi: 10.1186/s12885-020-07739-8. PMID: 33482769Free PMC Article
Zhao R, Ni D, Tian Y, Ni B, Wang A
Eur J Med Res 2014 Feb 18;19(1):9. doi: 10.1186/2047-783X-19-9. PMID: 24548763Free PMC Article
Wang CS, Yin QH, Liao JS, Lou JH, Ding XY, Zhu YB
Radiol Med 2013 Dec;118(8):1324-34. Epub 2013 May 27 doi: 10.1007/s11547-013-0936-9. PMID: 23716292

Diagnosis

Miskad UA, Syamsul F, Dahlan H, Sungowati NK, Achmad D, Johan MP
Asian Pac J Cancer Prev 2023 May 1;24(5):1737-1741. doi: 10.31557/APJCP.2023.24.5.1737. PMID: 37247296Free PMC Article
Santana LADM, Felix FA, de Arruda JAA, da Silva LP, Brito ÉAC, Takeshita WM, Trento CL
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 May;131(5):e163-e169. Epub 2020 Oct 17 doi: 10.1016/j.oooo.2020.10.009. PMID: 33187945
Chow LT
Virchows Arch 2016 Jun;468(6):741-55. Epub 2016 Mar 22 doi: 10.1007/s00428-016-1926-9. PMID: 27003154
Wang CS, Yin QH, Liao JS, Lou JH, Ding XY, Zhu YB
Radiol Med 2013 Dec;118(8):1324-34. Epub 2013 May 27 doi: 10.1007/s11547-013-0936-9. PMID: 23716292
Fu HH, Zhuang QW, He J, Wang LZ, He Y
J Craniofac Surg 2011 May;22(3):1136-9. doi: 10.1097/SCS.0b013e3182108fbf. PMID: 21586969

Therapy

Palmerini E, Seeger LL, Gambarotti M, Righi A, Reichardt P, Bukata S, Blay JY, Dai T, Jandial D, Picci P
BMC Cancer 2021 Jan 22;21(1):89. doi: 10.1186/s12885-020-07739-8. PMID: 33482769Free PMC Article
Chow LT
Virchows Arch 2016 Jun;468(6):741-55. Epub 2016 Mar 22 doi: 10.1007/s00428-016-1926-9. PMID: 27003154
Bertoni F, Bacchini P, Staals EL, Davidovitz P
Cancer 2005 Jun 1;103(11):2373-82. doi: 10.1002/cncr.21039. PMID: 15852358
Sato K, Yamamura S, Iwata H, Sugiura H, Nakashima N, Nagasaka T
Nagoya J Med Sci 1996 Dec;59(3-4):151-7. PMID: 9212641

Prognosis

Suzuki H, Ikeda H, Nishida N, Funaba M, Fujimoto K, Iwanaga R, Sakai T
Anticancer Res 2023 Oct;43(10):4739-4745. doi: 10.21873/anticanres.16671. PMID: 37772568
Karczewski D, Gonzalez MR, Bedi A, Ready JE, Anderson ME, Lozano-Calderon SA
J Surg Oncol 2023 Oct;128(5):877-890. Epub 2023 Jun 9 doi: 10.1002/jso.27368. PMID: 37292033
Chow LT
Virchows Arch 2016 Jun;468(6):741-55. Epub 2016 Mar 22 doi: 10.1007/s00428-016-1926-9. PMID: 27003154
Zhao R, Ni D, Tian Y, Ni B, Wang A
Eur J Med Res 2014 Feb 18;19(1):9. doi: 10.1186/2047-783X-19-9. PMID: 24548763Free PMC Article
Wang CS, Yin QH, Liao JS, Lou JH, Ding XY, Zhu YB
Radiol Med 2013 Dec;118(8):1324-34. Epub 2013 May 27 doi: 10.1007/s11547-013-0936-9. PMID: 23716292

Clinical prediction guides

Karczewski D, Gonzalez MR, Bedi A, Ready JE, Anderson ME, Lozano-Calderon SA
J Surg Oncol 2023 Oct;128(5):877-890. Epub 2023 Jun 9 doi: 10.1002/jso.27368. PMID: 37292033
Miskad UA, Syamsul F, Dahlan H, Sungowati NK, Achmad D, Johan MP
Asian Pac J Cancer Prev 2023 May 1;24(5):1737-1741. doi: 10.31557/APJCP.2023.24.5.1737. PMID: 37247296Free PMC Article
Palmerini E, Seeger LL, Gambarotti M, Righi A, Reichardt P, Bukata S, Blay JY, Dai T, Jandial D, Picci P
BMC Cancer 2021 Jan 22;21(1):89. doi: 10.1186/s12885-020-07739-8. PMID: 33482769Free PMC Article
Santana LADM, Felix FA, de Arruda JAA, da Silva LP, Brito ÉAC, Takeshita WM, Trento CL
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 May;131(5):e163-e169. Epub 2020 Oct 17 doi: 10.1016/j.oooo.2020.10.009. PMID: 33187945
Shooshtarizadeh T, Rahimi M, Movahedinia S
Pathol Res Pract 2016 Oct;212(10):876-879. Epub 2016 Jul 14 doi: 10.1016/j.prp.2016.07.007. PMID: 27473669

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