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Ovarian Leydig Cell Hyperplasia

MedGen UID:: 1792204
•Concept ID:: C5555763
•: Pathologic Function

Synonym:

Hilar Cell Hyperplasia

Definition

An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOvarian Leydig Cell Hyperplasia

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Special Category
        Hyperplasia
        Ovarian Leydig Cell Hyperplasia

Professional guidelines

PubMed

From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.

Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.

Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Diagnosis and management of hirsute women.

Badawy SZ
Int J Fertil 1987 Sep-Oct;32(5):349-57. PMID: 2889680

See all (4)

Recent clinical studies

Etiology

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301 Free PMC Article

Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic?

Carrasco-Juan JL, Álvarez-Argüelles-Cabrera H, Martín-Corriente C, Gutiérrez-García R, Vega-Falcón A, Expósito-Afonso I, Méndez-Medina R, Díaz-Flores L
Arch Gynecol Obstet 2018 Sep;298(3):655-661. Epub 2018 Jul 3 doi: 10.1007/s00404-018-4846-x. PMID: 29971558

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557 Free PMC Article

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.

Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Sex cord-stromal and steroid cell tumors of the ovary.

Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B
Radiographics 1998 Nov-Dec;18(6):1523-46. doi: 10.1148/radiographics.18.6.9821198. PMID: 9821198

See all (17)

Diagnosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301 Free PMC Article

Sertoli Leydig Cell Tumour Initially Misdiagnosed as Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia: A Case Report.

Paudyal P, Gurung G, Baral J, Kharel N
JNMA J Nepal Med Assoc 2020 Nov 22;58(231):923-926. doi: 10.31729/jnma.5045. PMID: 34506429 Free PMC Article

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.

Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Sex cord-stromal and steroid cell tumors of the ovary.

Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B
Radiographics 1998 Nov-Dec;18(6):1523-46. doi: 10.1148/radiographics.18.6.9821198. PMID: 9821198

See all (43)

Therapy

Radioimmunoassays of ethinyl-norgestrienone (R-2323) and medroxyprogesterone acetate (MPA) and their clinical applicability.

Frick J, Bartsch G, Jakse G
Urol Res 1977;5(2):55-9. doi: 10.1007/BF00256842. PMID: 69351

Arrhenoblastoma associated with adrenal androgenic hyperfunction.

Cruikshank DP, Yannone ME, Chapler FK
Obstet Gynecol 1974 Apr;43(4):535-8. PMID: 4361441

Gynecologic endocrine disorders in childhood and adolescence.

Huffman JW
Clin Obstet Gynecol 1973 Dec;16(4):51-81. doi: 10.1097/00003081-197312000-00004. PMID: 4361634

Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism; report of a case with hormone studies.

EPSTEIN JA, LEVINSON CJ, KUPPERMAN HS
Am J Obstet Gynecol 1957 Nov;74(5):982-8. doi: 10.1016/0002-9378(57)90141-2. PMID: 13469882

See all (4)

Prognosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301 Free PMC Article

Sertoli Leydig Cell Tumour Initially Misdiagnosed as Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia: A Case Report.

Paudyal P, Gurung G, Baral J, Kharel N
JNMA J Nepal Med Assoc 2020 Nov 22;58(231):923-926. doi: 10.31729/jnma.5045. PMID: 34506429 Free PMC Article

Leydig cell hyperplasia and Leydig cell tumour in postmenopausal women: report of two cases.

Hofland M, Cosyns S, De Sutter P, Bourgain C, Velkeniers B
Gynecol Endocrinol 2013 Mar;29(3):213-5. Epub 2012 Jul 26 doi: 10.3109/09513590.2012.705375. PMID: 22835278

Androblastoma of the ovary: clinical, diagnostic and histopathologic features.

Fleckenstein G, Sattler B, Hinney B, Wuttke W, Osmers R, Emons G
Onkologie 2001 Jun;24(3):286-91. doi: 10.1159/000055094. PMID: 11455224

A virilizing Leydig cell tumor of the ovary associated with stromal hyperplasia under gonadotropin control.

Marcondes JA, Nery M, Mendonça BB, Hayashida SA, Halbe HW, Carvalho FM, Wajchenberg BL
J Endocrinol Invest 1997 Dec;20(11):685-9. doi: 10.1007/BF03348033. PMID: 9492110

See all (9)

Clinical prediction guides

Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases.

McHenry A, Buza N
Int J Gynecol Pathol 2023 Mar 1;42(2):167-175. Epub 2022 Apr 12 doi: 10.1097/PGP.0000000000000887. PMID: 35512214

Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma.

Reijnen C, Küsters-Vandevelde HVN, Abbink K, Zusterzeel PLM, van Herwaarden AE, van der Laak JAWM, Massuger LFAG, Snijders MPLM, Pijnenborg JMA, Bulten J
Hum Pathol 2019 Mar;85:119-127. Epub 2018 Nov 11 doi: 10.1016/j.humpath.2018.10.022. PMID: 30428390

Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic?

Ovarian Leydig cells (OLC): A histomorphological and immunohistochemical study.

Carrasco-Juan JL, Álvarez-Argüelles Cabrera H, Martín Corriente MC, González-Gómez M, Valladares Parrilla R, Gutiérrez García R, Díaz-Flores L
Histol Histopathol 2017 Oct;32(10):1089-1097. Epub 2017 Jan 27 doi: 10.14670/HH-11-876. PMID: 28127725

Leydig cell hyperplasia and Leydig cell tumour in postmenopausal women: report of two cases.

Hofland M, Cosyns S, De Sutter P, Bourgain C, Velkeniers B
Gynecol Endocrinol 2013 Mar;29(3):213-5. Epub 2012 Jul 26 doi: 10.3109/09513590.2012.705375. PMID: 22835278

See all (13)

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Ovarian Leydig Cell Hyperplasia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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