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Ovarian Leydig Cell Hyperplasia

MedGen UID:
1792204
Concept ID:
C5555763
Pathologic Function
Synonym: Hilar Cell Hyperplasia

Definition

An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Leydig Cell Hyperplasia

Professional guidelines

PubMed

Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Badawy SZ
Int J Fertil 1987 Sep-Oct;32(5):349-57. PMID: 2889680

Recent clinical studies

Etiology

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Reijnen C, Küsters-Vandevelde HVN, Abbink K, Zusterzeel PLM, van Herwaarden AE, van der Laak JAWM, Massuger LFAG, Snijders MPLM, Pijnenborg JMA, Bulten J
Hum Pathol 2019 Mar;85:119-127. Epub 2018 Nov 11 doi: 10.1016/j.humpath.2018.10.022. PMID: 30428390
Carrasco-Juan JL, Álvarez-Argüelles-Cabrera H, Martín-Corriente C, Gutiérrez-García R, Vega-Falcón A, Expósito-Afonso I, Méndez-Medina R, Díaz-Flores L
Arch Gynecol Obstet 2018 Sep;298(3):655-661. Epub 2018 Jul 3 doi: 10.1007/s00404-018-4846-x. PMID: 29971558
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Diagnosis

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B
Radiographics 1998 Nov-Dec;18(6):1523-46. doi: 10.1148/radiographics.18.6.9821198. PMID: 9821198

Therapy

Frick J, Bartsch G, Jakse G
Urol Res 1977;5(2):55-9. doi: 10.1007/BF00256842. PMID: 69351

Prognosis

Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Paudyal P, Gurung G, Baral J, Kharel N
JNMA J Nepal Med Assoc 2020 Nov 22;58(231):923-926. doi: 10.31729/jnma.5045. PMID: 34506429Free PMC Article
Hofland M, Cosyns S, De Sutter P, Bourgain C, Velkeniers B
Gynecol Endocrinol 2013 Mar;29(3):213-5. Epub 2012 Jul 26 doi: 10.3109/09513590.2012.705375. PMID: 22835278
Fleckenstein G, Sattler B, Hinney B, Wuttke W, Osmers R, Emons G
Onkologie 2001 Jun;24(3):286-91. doi: 10.1159/000055094. PMID: 11455224
Marcondes JA, Nery M, Mendonça BB, Hayashida SA, Halbe HW, Carvalho FM, Wajchenberg BL
J Endocrinol Invest 1997 Dec;20(11):685-9. doi: 10.1007/BF03348033. PMID: 9492110

Clinical prediction guides

McHenry A, Buza N
Int J Gynecol Pathol 2023 Mar 1;42(2):167-175. Epub 2022 Apr 12 doi: 10.1097/PGP.0000000000000887. PMID: 35512214
Reijnen C, Küsters-Vandevelde HVN, Abbink K, Zusterzeel PLM, van Herwaarden AE, van der Laak JAWM, Massuger LFAG, Snijders MPLM, Pijnenborg JMA, Bulten J
Hum Pathol 2019 Mar;85:119-127. Epub 2018 Nov 11 doi: 10.1016/j.humpath.2018.10.022. PMID: 30428390
Carrasco-Juan JL, Álvarez-Argüelles-Cabrera H, Martín-Corriente C, Gutiérrez-García R, Vega-Falcón A, Expósito-Afonso I, Méndez-Medina R, Díaz-Flores L
Arch Gynecol Obstet 2018 Sep;298(3):655-661. Epub 2018 Jul 3 doi: 10.1007/s00404-018-4846-x. PMID: 29971558
Carrasco-Juan JL, Álvarez-Argüelles Cabrera H, Martín Corriente MC, González-Gómez M, Valladares Parrilla R, Gutiérrez García R, Díaz-Flores L
Histol Histopathol 2017 Oct;32(10):1089-1097. Epub 2017 Jan 27 doi: 10.14670/HH-11-876. PMID: 28127725
Hofland M, Cosyns S, De Sutter P, Bourgain C, Velkeniers B
Gynecol Endocrinol 2013 Mar;29(3):213-5. Epub 2012 Jul 26 doi: 10.3109/09513590.2012.705375. PMID: 22835278

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