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Bladder Urothelial Carcinoma, High Grade

MedGen UID:
1792939
Concept ID:
C5556498
Neoplastic Process
Synonyms: Bladder Urothelial Carcinoma, High-Grade; High Grade Bladder Urothelial Carcinoma; High-Grade Bladder Urothelial Carcinoma

Definition

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Klaassen Z, Kamat AM, Kassouf W, Gontero P, Villavicencio H, Bellmunt J, van Rhijn BWG, Hartmann A, Catto JWF, Kulkarni GS
Eur Urol 2018 Nov;74(5):597-608. Epub 2018 Jul 13 doi: 10.1016/j.eururo.2018.06.024. PMID: 30017405

Recent clinical studies

Etiology

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Yip W, Ashrafi A, Daneshmand S
Curr Urol Rep 2019 Nov 28;20(12):79. doi: 10.1007/s11934-019-0945-x. PMID: 31781979
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268

Diagnosis

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Dum D, Menz A, Völkel C, De Wispelaere N, Hinsch A, Gorbokon N, Lennartz M, Luebke AM, Hube-Magg C, Kluth M, Fraune C, Möller K, Bernreuther C, Lebok P, Clauditz TS, Jacobsen F, Sauter G, Uhlig R, Wilczak W, Steurer S, Minner S, Marx AH, Simon R, Burandt E, Krech T
Exp Mol Pathol 2022 Jun;126:104762. Epub 2022 Apr 4 doi: 10.1016/j.yexmp.2022.104762. PMID: 35390310
Porten SP
Curr Urol Rep 2018 Oct 24;19(12):102. doi: 10.1007/s11934-018-0861-5. PMID: 30357502

Therapy

Coleman JA, Yip W, Wong NC, Sjoberg DD, Bochner BH, Dalbagni G, Donat SM, Herr HW, Cha EK, Donahue TF, Pietzak EJ, Hakimi AA, Kim K, Al-Ahmadie HA, Vargas HA, Alvim RG, Ghafoor S, Benfante NE, Meraney AM, Shichman SJ, Kamradt JM, Nair SG, Baccala AA Jr, Palyca P, Lash BW, Rizvi MA, Swanson SK, Muina AF, Apolo AB, Iyer G, Rosenberg JE, Teo MY, Bajorin DF
J Clin Oncol 2023 Mar 10;41(8):1618-1625. Epub 2023 Jan 5 doi: 10.1200/JCO.22.00763. PMID: 36603175Free PMC Article
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Sternberg CN, Skoneczna I, Kerst JM, Albers P, Fossa SD, Agerbaek M, Dumez H, de Santis M, Théodore C, Leahy MG, Chester JD, Verbaeys A, Daugaard G, Wood L, Witjes JA, de Wit R, Geoffrois L, Sengelov L, Thalmann G, Charpentier D, Rolland F, Mignot L, Sundar S, Symonds P, Graham J, Joly F, Marreaud S, Collette L, Sylvester R; European Organisation for Research and Treatment of Cancer Genito-Urinary Cancers Group; Groupe d'Etude des Tumeurs Urogénitales; National Cancer Research Institute Bladder Cancer Study Group; National Cancer Institute of Canada Clinical Trials Group; German Association of Urologic Oncology
Lancet Oncol 2015 Jan;16(1):76-86. Epub 2014 Dec 11 doi: 10.1016/S1470-2045(14)71160-X. PMID: 25498218

Prognosis

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Hurst CD, Knowles MA
Urol Oncol 2022 Jul;40(7):295-303. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.10.015. PMID: 30446444
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268

Clinical prediction guides

Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Lopez-Beltran A, Blanca A, Cimadamore A, Montironi R, Luque RJ, Volavšek M, Cheng L
Virchows Arch 2022 May;480(5):989-998. Epub 2022 Feb 4 doi: 10.1007/s00428-021-03264-6. PMID: 35122124Free PMC Article
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Solomon JP, Hansel DE
Surg Pathol Clin 2016 Sep;9(3):391-404. doi: 10.1016/j.path.2016.04.004. PMID: 27523968

Recent systematic reviews

Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702
Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, Lotan Y
Eur Urol 2014 Aug;66(2):253-62. Epub 2014 Jan 21 doi: 10.1016/j.eururo.2014.01.006. PMID: 24472711
Izquierdo L, Bolton DM, Lawrentschuk N
Minerva Urol Nefrol 2013 Dec;65(4):225-34. PMID: 24091476
Palou J, Wood D, Bochner BH, van der Poel H, Al-Ahmadie HA, Yossepowitch O, Soloway MS, Jenkins LC; International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Eur Urol 2013 Jan;63(1):81-7. Epub 2012 Aug 14 doi: 10.1016/j.eururo.2012.08.011. PMID: 22938869

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