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Bladder Urothelial Carcinoma, High Grade

MedGen UID:
1792939
•Concept ID:
C5556498
•
Neoplastic Process
Synonyms: Bladder Urothelial Carcinoma, High-Grade; High Grade Bladder Urothelial Carcinoma; High-Grade Bladder Urothelial Carcinoma

Definition

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Treatment Strategy for Newly Diagnosed T1 High-grade Bladder Urothelial Carcinoma: New Insights and Updated Recommendations.
Klaassen Z, Kamat AM, Kassouf W, Gontero P, Villavicencio H, Bellmunt J, van Rhijn BWG, Hartmann A, Catto JWF, Kulkarni GS
Eur Urol 2018 Nov;74(5):597-608. Epub 2018 Jul 13 doi: 10.1016/j.eururo.2018.06.024. PMID: 30017405

Recent clinical studies

Etiology

Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma.
Coleman JA, Yip W, Wong NC, Sjoberg DD, Bochner BH, Dalbagni G, Donat SM, Herr HW, Cha EK, Donahue TF, Pietzak EJ, Hakimi AA, Kim K, Al-Ahmadie HA, Vargas HA, Alvim RG, Ghafoor S, Benfante NE, Meraney AM, Shichman SJ, Kamradt JM, Nair SG, Baccala AA Jr, Palyca P, Lash BW, Rizvi MA, Swanson SK, Muina AF, Apolo AB, Iyer G, Rosenberg JE, Teo MY, Bajorin DF
J Clin Oncol 2023 Mar 10;41(8):1618-1625. Epub 2023 Jan 5 doi: 10.1200/JCO.22.00763. PMID: 36603175Free PMC Article
Efficacy and toxicity of antibody-drug conjugates in the treatment of metastatic urothelial cancer: A scoping review.
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Management of High-grade T1 Urothelial Carcinoma.
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R, Colecchia M, Giannatempo P, Mortarini R, Bianchi M, Farè E, Monopoli F, Colombo R, Gallina A, Salonia A, Messina A, Ali SM, Madison R, Ross JS, Chung JH, Salvioni R, Mariani L, Montorsi F
J Clin Oncol 2018 Dec 1;36(34):3353-3360. Epub 2018 Oct 20 doi: 10.1200/JCO.18.01148. PMID: 30343614
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428

Diagnosis

pT1 high-grade bladder cancer: histologic criteria, pitfalls in the assessment of invasion, and substaging.
Raspollini MR, Montironi R, Mazzucchelli R, Cimadamore A, Cheng L, Lopez-Beltran A
Virchows Arch 2020 Jul;477(1):3-16. Epub 2020 Apr 15 doi: 10.1007/s00428-020-02808-6. PMID: 32296929
Urothelial Carcinoma In Situ (CIS): New Insights.
Akhtar M, Al-Bozom IA, Ben Gashir M, Taha NM, Rashid S, Al-Nabet ADMH
Adv Anat Pathol 2019 Sep;26(5):313-319. doi: 10.1097/PAP.0000000000000239. PMID: 31149909
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
Dysplasia and carcinoma in situ of the urinary bladder.
Lopez-Beltran A, Marques RC, Montironi R, Reymundo C, Fonseca J, Cheng L
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):29-38. PMID: 26072632
High-grade Ta urothelial carcinoma and carcinoma in situ of the bladder.
Sylvester RJ, van der Meijden A, Witjes JA, Jakse G, Nonomura N, Cheng C, Torres A, Watson R, Kurth KH
Urology 2005 Dec;66(6 Suppl 1):90-107. doi: 10.1016/j.urology.2005.06.135. PMID: 16399418

Therapy

Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma.
Coleman JA, Yip W, Wong NC, Sjoberg DD, Bochner BH, Dalbagni G, Donat SM, Herr HW, Cha EK, Donahue TF, Pietzak EJ, Hakimi AA, Kim K, Al-Ahmadie HA, Vargas HA, Alvim RG, Ghafoor S, Benfante NE, Meraney AM, Shichman SJ, Kamradt JM, Nair SG, Baccala AA Jr, Palyca P, Lash BW, Rizvi MA, Swanson SK, Muina AF, Apolo AB, Iyer G, Rosenberg JE, Teo MY, Bajorin DF
J Clin Oncol 2023 Mar 10;41(8):1618-1625. Epub 2023 Jan 5 doi: 10.1200/JCO.22.00763. PMID: 36603175Free PMC Article
Efficacy and toxicity of antibody-drug conjugates in the treatment of metastatic urothelial cancer: A scoping review.
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R, Colecchia M, Giannatempo P, Mortarini R, Bianchi M, Farè E, Monopoli F, Colombo R, Gallina A, Salonia A, Messina A, Ali SM, Madison R, Ross JS, Chung JH, Salvioni R, Mariani L, Montorsi F
J Clin Oncol 2018 Dec 1;36(34):3353-3360. Epub 2018 Oct 20 doi: 10.1200/JCO.18.01148. PMID: 30343614
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428

Prognosis

Mutational landscape of non-muscle-invasive bladder cancer.
Hurst CD, Knowles MA
Urol Oncol 2022 Jul;40(7):295-303. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.10.015. PMID: 30446444
pT1 high-grade bladder cancer: histologic criteria, pitfalls in the assessment of invasion, and substaging.
Raspollini MR, Montironi R, Mazzucchelli R, Cimadamore A, Cheng L, Lopez-Beltran A
Virchows Arch 2020 Jul;477(1):3-16. Epub 2020 Apr 15 doi: 10.1007/s00428-020-02808-6. PMID: 32296929
Management of High-grade T1 Urothelial Carcinoma.
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
High-grade Ta urothelial carcinoma and carcinoma in situ of the bladder.
Sylvester RJ, van der Meijden A, Witjes JA, Jakse G, Nonomura N, Cheng C, Torres A, Watson R, Kurth KH
Urology 2005 Dec;66(6 Suppl 1):90-107. doi: 10.1016/j.urology.2005.06.135. PMID: 16399418

Clinical prediction guides

Efficacy and toxicity of antibody-drug conjugates in the treatment of metastatic urothelial cancer: A scoping review.
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
T1 bladder carcinoma with variant histology: pathological features and clinical significance.
Lopez-Beltran A, Blanca A, Cimadamore A, Montironi R, Luque RJ, Volavšek M, Cheng L
Virchows Arch 2022 May;480(5):989-998. Epub 2022 Feb 4 doi: 10.1007/s00428-021-03264-6. PMID: 35122124Free PMC Article
Management of High-grade T1 Urothelial Carcinoma.
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R, Colecchia M, Giannatempo P, Mortarini R, Bianchi M, Farè E, Monopoli F, Colombo R, Gallina A, Salonia A, Messina A, Ali SM, Madison R, Ross JS, Chung JH, Salvioni R, Mariani L, Montorsi F
J Clin Oncol 2018 Dec 1;36(34):3353-3360. Epub 2018 Oct 20 doi: 10.1200/JCO.18.01148. PMID: 30343614
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Diagnostic Accuracy of Novel Urinary Biomarker Tests in Non-muscle-invasive Bladder Cancer: A Systematic Review and Network Meta-analysis.
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702
Radical cystectomy and orthotopic bladder substitution: surgical tricks and management of complications.
Izquierdo L, Bolton DM, Lawrentschuk N
Minerva Urol Nefrol 2013 Dec;65(4):225-34. PMID: 24091476
ICUD-EAU International Consultation on Bladder Cancer 2012: Urothelial carcinoma of the prostate.
Palou J, Wood D, Bochner BH, van der Poel H, Al-Ahmadie HA, Yossepowitch O, Soloway MS, Jenkins LC; International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Eur Urol 2013 Jan;63(1):81-7. Epub 2012 Aug 14 doi: 10.1016/j.eururo.2012.08.011. PMID: 22938869
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder.
Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A, Palou-Redorta J; European Association of Urology (EAU)
Eur Urol 2008 Aug;54(2):303-14. Epub 2008 Apr 30 doi: 10.1016/j.eururo.2008.04.051. PMID: 18468779

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