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Deleterious ROS1 Gene Mutation

MedGen UID:
1793077
•Concept ID:
C5556636
•
Cell or Molecular Dysfunction
Synonyms: Deleterious c-ros-1 Gene Mutation; Deleterious MCF3 Gene Mutation; Deleterious ROS Gene Mutation; Deleterious ROS Proto-Oncogene 1, Receptor Tyrosine Kinase Gene Mutation; Deleterious ROS1 Mutation; ROS1 Driver Mutation

Definition

A change in the nucleotide sequence of the ROS1 gene that is associated with increased risk of disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeleterious ROS1 Gene Mutation

Recent clinical studies

Etiology

Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer.
Liang X, Vacher S, Boulai A, Bernard V, Baulande S, Bohec M, Bièche I, Lerebours F, Callens C
Breast Cancer Res 2018 Aug 7;20(1):88. doi: 10.1186/s13058-018-1007-x. PMID: 30086764Free PMC Article
Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma.
Preusser M, Berghoff AS, Koller R, Zielinski CC, Hainfellner JA, Liebmann-Reindl S, Popitsch N, Geier CB, Streubel B, Birner P
Eur J Cancer 2015 Sep;51(13):1803-11. Epub 2015 Jul 8 doi: 10.1016/j.ejca.2015.06.107. PMID: 26164066

Diagnosis

Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.
Johnson A, Severson E, Gay L, Vergilio JA, Elvin J, Suh J, Daniel S, Covert M, Frampton GM, Hsu S, Lesser GJ, Stogner-Underwood K, Mott RT, Rush SZ, Stanke JJ, Dahiya S, Sun J, Reddy P, Chalmers ZR, Erlich R, Chudnovsky Y, Fabrizio D, Schrock AB, Ali S, Miller V, Stephens PJ, Ross J, Crawford JR, Ramkissoon SH
Oncologist 2017 Dec;22(12):1478-1490. Epub 2017 Sep 14 doi: 10.1634/theoncologist.2017-0242. PMID: 28912153Free PMC Article
Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma.
Preusser M, Berghoff AS, Koller R, Zielinski CC, Hainfellner JA, Liebmann-Reindl S, Popitsch N, Geier CB, Streubel B, Birner P
Eur J Cancer 2015 Sep;51(13):1803-11. Epub 2015 Jul 8 doi: 10.1016/j.ejca.2015.06.107. PMID: 26164066

Therapy

Genetic determinants of lung cancer: Understanding the oncogenic potential of somatic missense mutations.
Dhakar R, Dakal TC, Sharma A
Genomics 2022 Jul;114(4):110401. Epub 2022 Jun 14 doi: 10.1016/j.ygeno.2022.110401. PMID: 35709927

Prognosis

Genetic determinants of lung cancer: Understanding the oncogenic potential of somatic missense mutations.
Dhakar R, Dakal TC, Sharma A
Genomics 2022 Jul;114(4):110401. Epub 2022 Jun 14 doi: 10.1016/j.ygeno.2022.110401. PMID: 35709927
Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer.
Liang X, Vacher S, Boulai A, Bernard V, Baulande S, Bohec M, Bièche I, Lerebours F, Callens C
Breast Cancer Res 2018 Aug 7;20(1):88. doi: 10.1186/s13058-018-1007-x. PMID: 30086764Free PMC Article
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.
Johnson A, Severson E, Gay L, Vergilio JA, Elvin J, Suh J, Daniel S, Covert M, Frampton GM, Hsu S, Lesser GJ, Stogner-Underwood K, Mott RT, Rush SZ, Stanke JJ, Dahiya S, Sun J, Reddy P, Chalmers ZR, Erlich R, Chudnovsky Y, Fabrizio D, Schrock AB, Ali S, Miller V, Stephens PJ, Ross J, Crawford JR, Ramkissoon SH
Oncologist 2017 Dec;22(12):1478-1490. Epub 2017 Sep 14 doi: 10.1634/theoncologist.2017-0242. PMID: 28912153Free PMC Article
Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma.
Preusser M, Berghoff AS, Koller R, Zielinski CC, Hainfellner JA, Liebmann-Reindl S, Popitsch N, Geier CB, Streubel B, Birner P
Eur J Cancer 2015 Sep;51(13):1803-11. Epub 2015 Jul 8 doi: 10.1016/j.ejca.2015.06.107. PMID: 26164066

Clinical prediction guides

Genetic determinants of lung cancer: Understanding the oncogenic potential of somatic missense mutations.
Dhakar R, Dakal TC, Sharma A
Genomics 2022 Jul;114(4):110401. Epub 2022 Jun 14 doi: 10.1016/j.ygeno.2022.110401. PMID: 35709927
Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer.
Liang X, Vacher S, Boulai A, Bernard V, Baulande S, Bohec M, Bièche I, Lerebours F, Callens C
Breast Cancer Res 2018 Aug 7;20(1):88. doi: 10.1186/s13058-018-1007-x. PMID: 30086764Free PMC Article
Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma.
Preusser M, Berghoff AS, Koller R, Zielinski CC, Hainfellner JA, Liebmann-Reindl S, Popitsch N, Geier CB, Streubel B, Birner P
Eur J Cancer 2015 Sep;51(13):1803-11. Epub 2015 Jul 8 doi: 10.1016/j.ejca.2015.06.107. PMID: 26164066

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