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Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

MedGen UID:
1793103
•Concept ID:
C5556662
•
Neoplastic Process
Synonym: HPV-Independent Cervical Squamous Cell Carcinoma

Definition

A cervical squamous cell carcinoma not associated with human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman Papillomavirus-Independent Cervical Squamous Cell Carcinoma

Recent clinical studies

Etiology

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216
The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas.
Quabius ES, Möller P, Haag J, Pfannenschmidt S, Hedderich J, Görögh T, Röcken C, Hoffmann M
Int J Cancer 2014 Mar 15;134(6):1323-34. Epub 2013 Sep 23 doi: 10.1002/ijc.28462. PMID: 23996702

Diagnosis

Invasive Squamous Cell Carcinoma of the Cervix: A Review of Morphological Appearances Encountered in Human Papillomavirus-associated and Papillomavirus-independent Tumors and Precursor Lesions.
Stolnicu S, Allison D, Patrichi A, Flynn J, Iasonos A, Soslow RA
Adv Anat Pathol 2024 Jan 1;31(1):1-14. Epub 2023 Aug 28 doi: 10.1097/PAP.0000000000000411. PMID: 37638549
Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216

Therapy

The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas.
Quabius ES, Möller P, Haag J, Pfannenschmidt S, Hedderich J, Görögh T, Röcken C, Hoffmann M
Int J Cancer 2014 Mar 15;134(6):1323-34. Epub 2013 Sep 23 doi: 10.1002/ijc.28462. PMID: 23996702

Prognosis

Invasive Squamous Cell Carcinoma of the Cervix: A Review of Morphological Appearances Encountered in Human Papillomavirus-associated and Papillomavirus-independent Tumors and Precursor Lesions.
Stolnicu S, Allison D, Patrichi A, Flynn J, Iasonos A, Soslow RA
Adv Anat Pathol 2024 Jan 1;31(1):1-14. Epub 2023 Aug 28 doi: 10.1097/PAP.0000000000000411. PMID: 37638549
Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216
The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas.
Quabius ES, Möller P, Haag J, Pfannenschmidt S, Hedderich J, Görögh T, Röcken C, Hoffmann M
Int J Cancer 2014 Mar 15;134(6):1323-34. Epub 2013 Sep 23 doi: 10.1002/ijc.28462. PMID: 23996702

Clinical prediction guides

Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases.
Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216

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