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MYB Gene Rearrangement

MedGen UID:
1793172
•Concept ID:
C5556731
•
Cell or Molecular Dysfunction
Synonyms: Avian Myeloblastosis Viral Oncogene Homolog Rearrangement; c-MYB Rearrangement; Cmyb Rearrangement; efg Rearrangement; MYB Proto-Oncogene, Transcription Factor Rearrangement; MYB Rearrangement; V-Myb Avian Myeloblastosis Viral Oncogene Homolog Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the MYB gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMYB Gene Rearrangement

Professional guidelines

PubMed

Clinical utility of myb rearrangement detection and p63/p40 immunophenotyping in the diagnosis of adenoid cystic carcinoma of minor salivary glands: a pilot study.
Argyris PP, Wetzel SL, Greipp P, Wehrs RN, Knutson DL, Kloft-Nelson SM, García JJ, Koutlas IG
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar;121(3):282-9. Epub 2015 Oct 19 doi: 10.1016/j.oooo.2015.10.016. PMID: 26711711
Genotype markers and proto-oncogene analysis in the CD30-positive "malignant histiocytosis" DEL cell line with t(5;6)(q35;p21).
Gogusev J, Barbey S, Nezelof C
Int J Cancer 1990 Jul 15;46(1):106-12. doi: 10.1002/ijc.2910460120. PMID: 2163988

Recent clinical studies

Etiology

Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast.
Ji J, Zhang F, Duan F, Yang H, Hou J, Liu Y, Dai J, Liao Q, Chen X, Liu Q
Sci Rep 2022 May 19;12(1):8504. doi: 10.1038/s41598-022-12583-w. PMID: 35590093Free PMC Article
MYB rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma.
Baraban E, Zhang PJ, Jaffer S, Lubin D, Feldman M, Bleiweiss IJ, Nayak A
Histopathology 2018 Dec;73(6):897-903. Epub 2018 Oct 22 doi: 10.1111/his.13708. PMID: 30003572
Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.
Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH
Am J Surg Pathol 2013 Jun;37(6):836-44. doi: 10.1097/PAS.0b013e31827b1cd6. PMID: 23598962Free PMC Article

Diagnosis

MYB RNA In Situ Hybridization Is a Useful Diagnostic Tool to Distinguish Breast Adenoid Cystic Carcinoma From Other Triple-negative Breast Carcinomas.
Butcher MR, White MJ, Rooper LM, Argani P, Cimino-Mathews A
Am J Surg Pathol 2022 Jul 1;46(7):878-888. Epub 2022 May 9 doi: 10.1097/PAS.0000000000001913. PMID: 35522890
MYB rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma.
Baraban E, Zhang PJ, Jaffer S, Lubin D, Feldman M, Bleiweiss IJ, Nayak A
Histopathology 2018 Dec;73(6):897-903. Epub 2018 Oct 22 doi: 10.1111/his.13708. PMID: 30003572

Therapy

A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma.
Ho AL, Dunn L, Sherman EJ, Fury MG, Baxi SS, Chandramohan R, Dogan S, Morris LG, Cullen GD, Haque S, Sima CS, Ni A, Antonescu CR, Katabi N, Pfister DG
Ann Oncol 2016 Oct;27(10):1902-8. Epub 2016 Aug 26 doi: 10.1093/annonc/mdw287. PMID: 27566443Free PMC Article

Prognosis

Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast.
Ji J, Zhang F, Duan F, Yang H, Hou J, Liu Y, Dai J, Liao Q, Chen X, Liu Q
Sci Rep 2022 May 19;12(1):8504. doi: 10.1038/s41598-022-12583-w. PMID: 35590093Free PMC Article
MYB RNA In Situ Hybridization Is a Useful Diagnostic Tool to Distinguish Breast Adenoid Cystic Carcinoma From Other Triple-negative Breast Carcinomas.
Butcher MR, White MJ, Rooper LM, Argani P, Cimino-Mathews A
Am J Surg Pathol 2022 Jul 1;46(7):878-888. Epub 2022 May 9 doi: 10.1097/PAS.0000000000001913. PMID: 35522890

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