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Non-Synonymous KRAS Gene Mutation

MedGen UID:
1793174
Concept ID:
C5556733
Cell or Molecular Dysfunction
Synonyms: KRAS Gene Missense Mutation; KRAS Missense Mutation; Non-Synonymous c-K-ras Gene Mutation; Non-Synonymous KRAS Mutation; Non-Synonymous KRAS-2 Gene Mutation; Non-Synonymous KRAS2 Gene Mutation; Non-Synonymous v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Gene Mutation

Definition

A point mutation in the KRAS gene that encodes an amino acid substitution in the GTPase KRas protein. [from NCI]

Recent clinical studies

Etiology

Przybyła W, Gjersvoll Paulsen KM, Mishra CK, Nygård S, Engebretsen S, Ruud E, Trøen G, Beiske K, Baumbusch LO
PLoS One 2022;17(8):e0273280. Epub 2022 Aug 29 doi: 10.1371/journal.pone.0273280. PMID: 36037157Free PMC Article
Chun YJ, Choi JW, Hong MH, Jung D, Son H, Cho EK, Min YJ, Kim SW, Park K, Lee SS, Kim S, Kim HR, Cho BC; Korean Lung Cancer Consortium (KLCC)
PLoS One 2019;14(11):e0224379. Epub 2019 Nov 25 doi: 10.1371/journal.pone.0224379. PMID: 31765373Free PMC Article
Barnoud T, Parris JLD, Murphy ME
J Mol Cell Biol 2019 Jul 19;11(7):578-585. doi: 10.1093/jmcb/mjz052. PMID: 31152665Free PMC Article
Iida Y, Salomon MP, Hata K, Tran K, Ohe S, Griffiths CF, Hsu SC, Nelson N, Hoon DSB
BMC Cancer 2018 Oct 30;18(1):1054. doi: 10.1186/s12885-018-4977-2. PMID: 30373548Free PMC Article
Myte R, Gylling B, Häggström J, Schneede J, Löfgren-Burström A, Huyghe JR, Hallmans G, Meyer K, Johansson I, Ueland PM, Palmqvist R, Van Guelpen B
PLoS One 2018;13(4):e0196233. Epub 2018 Apr 25 doi: 10.1371/journal.pone.0196233. PMID: 29694444Free PMC Article

Diagnosis

Han DJ, Kim S, Lee SY, Moon Y, Kang SJ, Yoo J, Jeong HY, Cho HJ, Jeon JY, Sim BC, Kim J, Lee S, Xi R, Kim TM
Genome Med 2024 Aug 19;16(1):103. doi: 10.1186/s13073-024-01376-7. PMID: 39160568Free PMC Article
Echejoh G, Liu Y, Chung-Faye G, Charlton J, Moorhead J, Clark B, Davidson P, Sarker D, Ross P, Ooft ML
J Clin Pathol 2021 Nov;74(11):718-723. Epub 2020 Oct 29 doi: 10.1136/jclinpath-2020-206998. PMID: 33122190
Lozada JR, Geyer FC, Selenica P, Brown D, Alemar B, Merghoub T, Berger MF, Busam KJ, Halpern AC, Weigelt B, Reis-Filho JS, Hollmann TJ
Histopathology 2019 Jul;75(1):29-38. Epub 2019 May 24 doi: 10.1111/his.13843. PMID: 30791119Free PMC Article
Meng Q, Valentini D, Rao M, Moro CF, Paraschoudi G, Jäger E, Dodoo E, Rangelova E, Del Chiaro M, Maeurer M
Br J Cancer 2019 Jan;120(1):97-108. Epub 2018 Oct 31 doi: 10.1038/s41416-018-0262-z. PMID: 30377343Free PMC Article
Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR
Nature 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727. PMID: 21390130Free PMC Article

Therapy

Chun YJ, Choi JW, Hong MH, Jung D, Son H, Cho EK, Min YJ, Kim SW, Park K, Lee SS, Kim S, Kim HR, Cho BC; Korean Lung Cancer Consortium (KLCC)
PLoS One 2019;14(11):e0224379. Epub 2019 Nov 25 doi: 10.1371/journal.pone.0224379. PMID: 31765373Free PMC Article
Domingo E, Camps C, Kaisaki PJ, Parsons MJ, Mouradov D, Pentony MM, Makino S, Palmieri M, Ward RL, Hawkins NJ, Gibbs P, Askautrud H, Oukrif D, Wang H, Wood J, Tomlinson E, Bark Y, Kaur K, Johnstone EC, Palles C, Church DN, Novelli M, Danielsen HE, Sherlock J, Kerr D, Kerr R, Sieber O, Taylor JC, Tomlinson I
Lancet Gastroenterol Hepatol 2018 Sep;3(9):635-643. Epub 2018 Jul 2 doi: 10.1016/S2468-1253(18)30117-1. PMID: 30042065Free PMC Article
Schechter RB, Nagilla M, Joseph L, Reddy P, Khattri A, Watson S, Locati LD, Licitra L, Greco A, Pelosi G, Carcangiu ML, Lingen MW, Seiwert TY, Cohen EE
Cancer Lett 2015 Apr 10;359(2):269-74. Epub 2015 Jan 29 doi: 10.1016/j.canlet.2015.01.024. PMID: 25641339
Tranah GJ, Bugni J, Giovannucci E, Ma J, Fuchs C, Hines L, Samson L, Hunter DJ
Cancer Causes Control 2006 Jun;17(5):721-31. doi: 10.1007/s10552-006-0005-y. PMID: 16633920

Prognosis

Rao W, Yang L, Dai N, Zhang L, Liu J, Yang B, Li M, Shan J, Wang Q, Wang D
Clin Transl Oncol 2023 Jun;25(6):1767-1778. Epub 2023 Feb 5 doi: 10.1007/s12094-023-03074-z. PMID: 36739576
Przybyła W, Gjersvoll Paulsen KM, Mishra CK, Nygård S, Engebretsen S, Ruud E, Trøen G, Beiske K, Baumbusch LO
PLoS One 2022;17(8):e0273280. Epub 2022 Aug 29 doi: 10.1371/journal.pone.0273280. PMID: 36037157Free PMC Article
Meng Q, Valentini D, Rao M, Moro CF, Paraschoudi G, Jäger E, Dodoo E, Rangelova E, Del Chiaro M, Maeurer M
Br J Cancer 2019 Jan;120(1):97-108. Epub 2018 Oct 31 doi: 10.1038/s41416-018-0262-z. PMID: 30377343Free PMC Article
Iida Y, Salomon MP, Hata K, Tran K, Ohe S, Griffiths CF, Hsu SC, Nelson N, Hoon DSB
BMC Cancer 2018 Oct 30;18(1):1054. doi: 10.1186/s12885-018-4977-2. PMID: 30373548Free PMC Article
Domingo E, Camps C, Kaisaki PJ, Parsons MJ, Mouradov D, Pentony MM, Makino S, Palmieri M, Ward RL, Hawkins NJ, Gibbs P, Askautrud H, Oukrif D, Wang H, Wood J, Tomlinson E, Bark Y, Kaur K, Johnstone EC, Palles C, Church DN, Novelli M, Danielsen HE, Sherlock J, Kerr D, Kerr R, Sieber O, Taylor JC, Tomlinson I
Lancet Gastroenterol Hepatol 2018 Sep;3(9):635-643. Epub 2018 Jul 2 doi: 10.1016/S2468-1253(18)30117-1. PMID: 30042065Free PMC Article

Clinical prediction guides

Han DJ, Kim S, Lee SY, Moon Y, Kang SJ, Yoo J, Jeong HY, Cho HJ, Jeon JY, Sim BC, Kim J, Lee S, Xi R, Kim TM
Genome Med 2024 Aug 19;16(1):103. doi: 10.1186/s13073-024-01376-7. PMID: 39160568Free PMC Article
Rao W, Yang L, Dai N, Zhang L, Liu J, Yang B, Li M, Shan J, Wang Q, Wang D
Clin Transl Oncol 2023 Jun;25(6):1767-1778. Epub 2023 Feb 5 doi: 10.1007/s12094-023-03074-z. PMID: 36739576
Choi JY, Choi S, Lee M, Park YS, Sung JS, Chang WJ, Kim JW, Choi YJ, Kim J, Kim DS, Lee SH, Seok J, Park KH, Kim SH, Kim YH
Cancer Res Treat 2020 Jul;52(3):764-778. Epub 2020 Feb 16 doi: 10.4143/crt.2020.044. PMID: 32065847Free PMC Article
Chun YJ, Choi JW, Hong MH, Jung D, Son H, Cho EK, Min YJ, Kim SW, Park K, Lee SS, Kim S, Kim HR, Cho BC; Korean Lung Cancer Consortium (KLCC)
PLoS One 2019;14(11):e0224379. Epub 2019 Nov 25 doi: 10.1371/journal.pone.0224379. PMID: 31765373Free PMC Article
Tan H, Bao J, Zhou X
Sci Rep 2015 Jul 27;5:12566. doi: 10.1038/srep12566. PMID: 26212640Free PMC Article

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