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Hybrid Salivary Gland Tumor

MedGen UID:
1793275
•Concept ID:
C5556834
•
Neoplastic Process
Synonym: Hybrid Salivary Gland Neoplasm

Definition

A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHybrid Salivary Gland Tumor

Professional guidelines

PubMed

Patterns of EBV-positive cervical lymph node involvement in head and neck cancer and implications for the management of nasopharyngeal carcinoma T0 classification.
Luo WJ, Feng YF, Guo R, Tang LL, Chen L, Zhou GQ, Li WF, Liu X, Sun Y, Lin AH, Ma J, Mao YP
Oral Oncol 2019 Apr;91:7-12. Epub 2019 Feb 16 doi: 10.1016/j.oraloncology.2019.01.012. PMID: 30926066
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics.
Luk PP, Selinger CI, Eviston TJ, Lum T, Yu B, O'Toole SA, Clark JR, Gupta R
Pathology 2015 Dec;47(7):659-66. doi: 10.1097/PAT.0000000000000322. PMID: 26517645

Recent clinical studies

Etiology

The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients.
Fukumura M, Ishibashi K, Nakaguro M, Nagao T, Saida K, Urano M, Tanigawa M, Hirai H, Yagyuu T, Kikuchi K, Yada N, Sugita Y, Miyabe M, Hasegawa S, Goto M, Yamamoto H, Ohuchi T, Kusafuka K, Ogawa I, Suzuki H, Notohara K, Shimoda M, Tada Y, Kirita T, Takata T, Morinaga S, Maeda H, Warnakulasuriya S, Miyabe S, Nagao T
J Oral Pathol Med 2022 Sep;51(8):710-720. Epub 2022 Aug 15 doi: 10.1111/jop.13336. PMID: 35880805
ALK alterations in salivary gland carcinomas.
Majewska H, Gorczyński A, Czapiewski P, Menon R, Mueller J, Lakis S, Heuckmann JM, Laco J, Gupta R, Andreasen S, Stodulski D, Iliszko M, Dziadziuszko R, Jassem J, Heukamp LC, Biernat W
Virchows Arch 2021 May;478(5):933-941. Epub 2020 Nov 25 doi: 10.1007/s00428-020-02971-w. PMID: 33237469Free PMC Article
Ancillary testing strategies in salivary gland aspiration cytology: A practical pattern-based approach.
Griffith CC, Siddiqui MT, Schmitt AC
Diagn Cytopathol 2017 Sep;45(9):808-819. Epub 2017 Apr 14 doi: 10.1002/dc.23715. PMID: 28411379
Histologic grading and prognostic biomarkers in salivary gland carcinomas.
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736

Diagnosis

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Salivary gland lesions: recent advances and evolving concepts.
Gupta R, Balasubramanian D, Clark JR
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jun;119(6):661-74. Epub 2015 Mar 2 doi: 10.1016/j.oooo.2015.02.481. PMID: 25840511

Therapy

Retrospective Study of Cisplatin/Carboplatin, 5-Fluorouracil Plus Cetuximab (EXTREME) for Advanced-stage Salivary Gland Cancer.
Nakano T, Yasumatsu R, Hashimoto K, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
In Vivo 2022 Mar-Apr;36(2):979-984. doi: 10.21873/invivo.12790. PMID: 35241559Free PMC Article
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Genomic landscape of salivary gland tumors.
Kato S, Elkin SK, Schwaederle M, Tomson BN, Helsten T, Carter JL, Kurzrock R
Oncotarget 2015 Sep 22;6(28):25631-45. doi: 10.18632/oncotarget.4554. PMID: 26247885Free PMC Article
Salivary duct carcinoma of the parotid gland: is adjuvant HER-2-targeted therapy required?
Lee JS, Kwon OJ, Park JJ, Seo JH
J Oral Maxillofac Surg 2014 May;72(5):1023-31. Epub 2013 Nov 22 doi: 10.1016/j.joms.2013.11.014. PMID: 24480767
Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study.
Locati LD, Bossi P, Perrone F, Potepan P, Crippa F, Mariani L, Casieri P, Orsenigo M, Losa M, Bergamini C, Liberatoscioli C, Quattrone P, Calderone RG, Rinaldi G, Pilotti S, Licitra L
Oral Oncol 2009 Jul;45(7):574-8. Epub 2008 Sep 18 doi: 10.1016/j.oraloncology.2008.07.010. PMID: 18804410

Prognosis

Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients.
Fukumura M, Ishibashi K, Nakaguro M, Nagao T, Saida K, Urano M, Tanigawa M, Hirai H, Yagyuu T, Kikuchi K, Yada N, Sugita Y, Miyabe M, Hasegawa S, Goto M, Yamamoto H, Ohuchi T, Kusafuka K, Ogawa I, Suzuki H, Notohara K, Shimoda M, Tada Y, Kirita T, Takata T, Morinaga S, Maeda H, Warnakulasuriya S, Miyabe S, Nagao T
J Oral Pathol Med 2022 Sep;51(8):710-720. Epub 2022 Aug 15 doi: 10.1111/jop.13336. PMID: 35880805
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Salivary gland lesions: recent advances and evolving concepts.
Gupta R, Balasubramanian D, Clark JR
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jun;119(6):661-74. Epub 2015 Mar 2 doi: 10.1016/j.oooo.2015.02.481. PMID: 25840511

Clinical prediction guides

The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
NR4A3 Expression Is Consistently Absent in Acinic Cell Carcinomas of the Breast: A Potential Nosologic Shift.
Richardson ET, Selenica P, Pareja F, Cin PD, Hanlon E, Weigelt B, Reis-Filho JS, Hornick JL, Jo VY, Schnitt SJ
Mod Pathol 2023 Jun;36(6):100144. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100144. PMID: 36828363Free PMC Article
Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Immunohistochemical and molecular profile of salivary gland cancer in children.
Locati LD, Collini P, Imbimbo M, Barisella M, Testi A, Licitra LF, Löning T, Tiemann K, Quattrone P, Bimbatti E, Chiaravalli S, Casanova M, Tamborini E, Carta R, Gasparini P, Guzzo M, Massimino M, Ferrari A
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Jan 31 doi: 10.1002/pbc.26468. PMID: 28139061
Histologic grading and prognostic biomarkers in salivary gland carcinomas.
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736

Recent systematic reviews

Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389

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