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Male Reproductive System Carcinoma

MedGen UID:: 1793338
•Concept ID:: C5556897
•: Neoplastic Process

Definition

A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMale Reproductive System Carcinoma

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Carcinoma
        Genitourinary System Carcinoma
        Male Reproductive System Carcinoma
        Epididymal adenocarcinoma
        Penile carcinoma
        Adult Penile Carcinoma
        Metastatic Penile Carcinoma
        Advanced Penile Carcinoma
        Locally Advanced Penile Carcinoma
        Paget disease of the penis
        Penile Cancer by AJCC v6 Stage
        Stage 0 Penile Cancer AJCC v6
        Stage I Penile Cancer AJCC v6
        Stage II Penile Cancer AJCC v6
        Stage III Penile Cancer AJCC v6
        Stage IV Penile Cancer AJCC v6
        Penile Cancer by AJCC v7 Stage
        Stage 0 Penile Cancer AJCC v7
        Stage IV Penile Cancer AJCC v7
        Penile Cancer by AJCC v8 Stage
        Stage 0 Penile Cancer AJCC v8
        Stage I Penile Cancer AJCC v8
        Stage II Penile Cancer AJCC v8
        Stage III Penile Cancer AJCC v8
        Stage IV Penile Cancer AJCC v8
        Penis basal cell carcinoma
        Recurrent Penile Carcinoma
        Refractory Penile Carcinoma
        Squamous cell carcinoma of penis
        Human papillomavirus-related penile squamous cell carcinoma
        Papillary carcinoma of the penis
        Penis carcinoma in situ
        Prostate carcinoma
        Hereditary Prostate Carcinoma
        Hormone-resistant prostate carcinoma
        Invasive Prostate Carcinoma
        Adenosquamous prostate carcinoma
        Prostate adenocarcinoma
        Prostate adenoid cystic carcinoma
        Prostate Basal Cell Carcinoma
        Prostate Neuroendocrine Carcinoma
        Prostate squamous cell carcinoma
        Prostate Undifferentiated Carcinoma
        Localized Prostate Carcinoma
        Metastatic prostate carcinoma
        Advanced Prostate Carcinoma
        Castration-Naive Prostate Carcinoma
        Castration-resistant prostate carcinoma
        Castration-Sensitive Prostate Carcinoma
        Locally Advanced Prostate Carcinoma
        Metastatic Prostate Adenocarcinoma
        Metastatic Prostate Neuroendocrine Carcinoma
        Oligometastatic Prostate Carcinoma
        Prostate Carcinoma Metastatic in the Bone
        Prostate Carcinoma Metastatic in the Lung
        Prostate Carcinoma Metastatic in the Lymph Nodes
        Prostate Carcinoma Metastatic in the Pelvic Cavity
        Prostate Carcinoma Metastatic in the Soft Tissue
        Primary prostate urothelial carcinoma
        Prostatic Duct Urothelial Carcinoma
        Prostatic urethra urothelial carcinoma
        Prostate Cancer by AJCC v6 Stage
        Prostate Cancer by AJCC v7 Stage
        Prostate Adenocarcinoma by AJCC v7 Stage
        Stage I Prostate Cancer AJCC v7
        Stage II Prostate Cancer AJCC v7
        Stage III Prostate Cancer AJCC v7
        Stage IV Prostate Cancer AJCC v7
        Prostate Cancer by AJCC v8 Stage
        Stage I Prostate Cancer AJCC v8
        Stage II Prostate Cancer AJCC v8
        Stage III Prostate Cancer AJCC v8
        Stage IV Prostate Cancer AJCC v8
        Prostate Cancer by Whitmore-Jewett Stage
        Stage A Prostate Cancer
        Stage B Prostate Cancer
        Stage C Prostate Cancer
        Stage D Prostate Cancer
        Prostate Carcinoma by Gene Expression Profile
        Basal-Like Prostate Carcinoma
        Luminal A Prostate Carcinoma
        Luminal B Prostate Carcinoma
        Prostate Intraductal Carcinoma
        Recurrent Prostate Carcinoma
        Biochemically Recurrent Prostate Carcinoma
        Recurrent Prostate Adenocarcinoma
        Refractory Prostate Carcinoma
        Refractory Prostate Adenocarcinoma
        Unresectable Prostate Carcinoma
        Locally Advanced Unresectable Prostate Carcinoma
        Unresectable Castration-Resistant Prostate Carcinoma
        Recurrent Male Reproductive System Carcinoma
        Refractory Male Reproductive System Carcinoma
        Rete testis adenocarcinoma
        Seminal vesicle adenocarcinoma

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026 Free PMC Article

Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.

Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681

Clinical and molecular features of treatment-related neuroendocrine prostate cancer.

Akamatsu S, Inoue T, Ogawa O, Gleave ME
Int J Urol 2018 Apr;25(4):345-351. Epub 2018 Feb 3 doi: 10.1111/iju.13526. PMID: 29396873

See all (299)

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.

Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.

Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783

High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate.

Zhou M
Mod Pathol 2018 Jan;31(S1):S71-79. doi: 10.1038/modpathol.2017.138. PMID: 29297491

Carcinoma of the urethra.

Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100 Free PMC Article

See all (2584)

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026 Free PMC Article

Penoscrotal Paget's disease.

Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789

Urologic Dermatology: a Review.

Stamm AW, Kobashi KC, Stefanovic KB
Curr Urol Rep 2017 Aug;18(8):62. doi: 10.1007/s11934-017-0712-9. PMID: 28667573

Scrotal tumors.

Armas-Alvarez AL, Salinas-Sánchez AS, Atienzar-Tobarra M, Virseda-Rodríguez JA
Arch Esp Urol 2016 Mar;69(2):86-9. PMID: 26959967

See all (3253)

Therapy

The cytoreductive prostatectomy in metastatic prostate cancer: what the individual trials are hoping to answer.

Ranasinghe W, Chapin BF, Kim IY, Sooriakumaran P, Lawrentschuk N
BJU Int 2020 Jun;125(6):792-800. Epub 2020 Apr 7 doi: 10.1111/bju.15055. PMID: 32176456

Complications associated with intimate body piercings.

Lee B, Vangipuram R, Petersen E, Tyring SK
Dermatol Online J 2018 Jul 15;24(7) PMID: 30261561

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.

Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870 Free PMC Article

The dysfunctional foreskin.

Porter WM, Bunker CB
Int J STD AIDS 2001 Apr;12(4):216-20. doi: 10.1258/0956462011922922. PMID: 11319970

Immunotherapy of bladder cancer.

Nseyo UO, Lamm DL
Semin Surg Oncol 1997 Sep-Oct;13(5):342-9. doi: 10.1002/(sici)1098-2388(199709/10)13:5<342::aid-ssu8>3.0.co;2-d. PMID: 9259090

See all (1364)

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.

Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.

Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026 Free PMC Article

Imaging spectrum of NUT carcinomas.

Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821

Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.

Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

See all (2291)

Clinical prediction guides

Intraductal carcinoma of the prostate: What we know and what we do not know.

Chen X, Ding B, Zhang P, Geng S, Xu J, Han B
Pathol Res Pract 2018 May;214(5):612-618. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.003. PMID: 29628124

High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate.

Zhou M
Mod Pathol 2018 Jan;31(S1):S71-79. doi: 10.1038/modpathol.2017.138. PMID: 29297491

Carcinoma of the urethra.

Intraductal carcinoma of the prostate: a comprehensive and updated review.

Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604

Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline.

van Casteren NJ, Looijenga LH, Dohle GR
Int J Androl 2009 Aug;32(4):279-87. Epub 2008 Dec 22 doi: 10.1111/j.1365-2605.2008.00937.x. PMID: 19207616

See all (2401)

Recent systematic reviews

Urothelial Carcinoma and Prostate-specific Membrane Antigen: Cellular, Imaging, and Prognostic Implications.

Tariq A, McCart Reed AE, Morton A, Porten S, Vela I, Williams ED, Yaxley JW, Black PC, Roberts MJ
Eur Urol Focus 2022 Sep;8(5):1256-1269. Epub 2021 Aug 21 doi: 10.1016/j.euf.2021.07.016. PMID: 34429271

Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.

Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681

Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review.

Siepe G, Buwenge M, Nguyen NP, Macchia G, Deodato F, Cilla S, Mattiucci GC, Capocaccia I, Cammelli S, Guido A, Arcelli A, Ntreta M, Guerri S, Morganti AG
Anticancer Res 2018 Mar;38(3):1221-1230. doi: 10.21873/anticanres.12343. PMID: 29491044

Urethral recurrence after radical cystectomy for urothelial carcinoma: A systematic review and meta-analysis.

Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Kübler H, Stenzl A, Gakis G
Urol Oncol 2018 Feb;36(2):54-59. Epub 2017 Nov 28 doi: 10.1016/j.urolonc.2017.11.007. PMID: 29196179

Urologic complications of genitourinary schistosomiasis.

Khalaf I, Shokeir A, Shalaby M
World J Urol 2012 Feb;30(1):31-8. Epub 2011 Sep 10 doi: 10.1007/s00345-011-0751-7. PMID: 21909645

See all (28)

MedGen

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Send to:

Male Reproductive System Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity