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Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

MedGen UID:
1793822
•Concept ID:
C5557381
•
Neoplastic Process
Synonym: Vaginal Smooth Muscle Neoplasm of Uncertain Malignant Potential

Definition

A smooth muscle neoplasm that arises from the vagina and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Smooth Muscle Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.
Swanson AA, Howitt BE, Schoolmeester JK
Hum Pathol 2020 Sep;103:83-94. Epub 2020 Jul 17 doi: 10.1016/j.humpath.2020.06.008. PMID: 32687944
Criteria for Risk Stratification of Vulvar and Vaginal Smooth Muscle Tumors: An Evaluation of 71 Cases Comparing Proposed Classification Systems.
Sayeed S, Xing D, Jenkins SM, Weisman PS, Buehler D, Warmke L, Uram-Tuculescu C, Bakkum-Gamez JN, Howitt BE, Cortese C, Park KJ, Schoolmeester JK
Am J Surg Pathol 2018 Jan;42(1):84-94. doi: 10.1097/PAS.0000000000000920. PMID: 28786880Free PMC Article
TFE3 translocation-associated perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: morphology, immunophenotype, differential diagnosis.
Schoolmeester JK, Dao LN, Sukov WR, Wang L, Park KJ, Murali R, Hameed MR, Soslow RA
Am J Surg Pathol 2015 Mar;39(3):394-404. doi: 10.1097/PAS.0000000000000349. PMID: 25517951Free PMC Article

Recent clinical studies

Etiology

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Update on Mesenchymal Lesions of the Lower Female Genital Tract.
Croce S, Perret R, Le Loarer F
Surg Pathol Clin 2022 Jun;15(2):341-367. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.009. PMID: 35715165
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Prevalence and occult rates of uterine leiomyosarcoma.
Wang L, Li S, Zhang Z, Jia J, Shan B
Medicine (Baltimore) 2020 Aug 14;99(33):e21766. doi: 10.1097/MD.0000000000021766. PMID: 32872073Free PMC Article
Safety of Manual Morcellation After Vaginal or Laparoscopic-assisted Vaginal Hysterectomy.
Balgobin S, Maldonado PA, Chin K, Schaffer JI, Hamid CA
J Minim Invasive Gynecol 2016 May-Jun;23(4):542-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.014. PMID: 26802908

Diagnosis

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Paraurethral leiomyoma.
Pastor Navarro H, Martínez Ruiz J, Martínez Sanchíz C, Perán Teruel M, Segura Martín M, Pastor Guzman JM, Virseda Rodríguez J
Arch Esp Urol 2013 Oct;66(8):820-3. PMID: 24136487

Therapy

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Hydrosalpinx in a premenarcheal 14-year-old girl with the proliferation of smooth muscle cells in the isthmus of the fallopian tube: A case report.
Kamo N, Takahashi T, Soeda S, Jimbo M, Yoshida-Komiya H, Fujimori K
J Obstet Gynaecol Res 2023 Feb;49(2):769-774. Epub 2022 Oct 28 doi: 10.1111/jog.15481. PMID: 36305392
GnRH analogue followed by surgery in treatment of vaginal leiomyoma-a case report.
Liu Y, Wang X, He Y
Medicine (Baltimore) 2021 Feb 26;100(8):e24911. doi: 10.1097/MD.0000000000024911. PMID: 33663124Free PMC Article
Safety of Manual Morcellation After Vaginal or Laparoscopic-assisted Vaginal Hysterectomy.
Balgobin S, Maldonado PA, Chin K, Schaffer JI, Hamid CA
J Minim Invasive Gynecol 2016 May-Jun;23(4):542-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.014. PMID: 26802908
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature.
Crowley HM, Mohamed A, Baker P, Jayanthi VR, Ranalli M, Aldrink JH
J Pediatr Surg 2013 May;48(5):1118-22. doi: 10.1016/j.jpedsurg.2013.03.046. PMID: 23701791

Prognosis

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156

Clinical prediction guides

An unusual coincidence of giant cervical leiomyoma and incidental ovarian granulosa cell tumor: A case report.
Kotowski K, Małyszczak P, Towarek M, Jagasyk A, Murawski M, Sozański R
Medicine (Baltimore) 2023 Jul 28;102(30):e34387. doi: 10.1097/MD.0000000000034387. PMID: 37505129Free PMC Article
Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.
Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.
Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713

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