Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.

Impairment of bile flow due to obstruction in the small bile ducts within the liver.

The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.

The presence of fibrosis affecting the interlobular stroma of liver.

Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4).

Abnormally high level of conjugated bilirubin in the blood.

Abnormally increased serum levels of alkaline phosphatase activity.

Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.

Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.

An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.