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Possible increased risk of EBV-associated malignancies

MedGen UID:
1795385
•Concept ID:
C5563175
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPossible increased risk of EBV-associated malignancies

Recent clinical studies

Etiology

Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage.
Uehara K, Tanabe Y, Hirota S, Higa S, Toyoda Z, Kurima K, Kina S, Nakasone T, Arasaki A, Kinjo T
BMC Cancer 2021 Jun 10;21(1):688. doi: 10.1186/s12885-021-08397-0. PMID: 34112111Free PMC Article
The Epstein-Barr Virus (EBV) in T Cell and NK Cell Lymphomas: Time for a Reassessment.
Gru AA, Haverkos BH, Freud AG, Hastings J, Nowacki NB, Barrionuevo C, Vigil CE, Rochford R, Natkunam Y, Baiocchi RA, Porcu P
Curr Hematol Malig Rep 2015 Dec;10(4):456-67. doi: 10.1007/s11899-015-0292-z. PMID: 26449716Free PMC Article
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, Khalil M, Wu MF, Huls MH, Chang CC, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE
Blood 2007 Oct 15;110(8):2838-45. Epub 2007 Jul 3 doi: 10.1182/blood-2007-05-091280. PMID: 17609424Free PMC Article
Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls.
de Sanjosé S, Bosch R, Schouten T, Verkuijlen S, Nieters A, Foretova L, Maynadié M, Cocco PL, Staines A, Becker N, Brennan P, Benavente Y, Boffetta P, Meijer CJ, Middeldorp JM
Int J Cancer 2007 Oct 15;121(8):1806-12. doi: 10.1002/ijc.22857. PMID: 17557295
Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer.
Hirunsatit R, Kongruttanachok N, Shotelersuk K, Supiyaphun P, Voravud N, Sakuntabhai A, Mutirangura A
BMC Genet 2003 Jan 21;4:3. doi: 10.1186/1471-2156-4-3. PMID: 12546713Free PMC Article

Diagnosis

Diagnosis and treatment of transplant-related lymphoma.
Swinnen LJ
Ann Oncol 2000;11 Suppl 1:45-8. PMID: 10707778

Therapy

A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation.
Uhlin M, Okas M, Gertow J, Uzunel M, Brismar TB, Mattsson J
Cancer Immunol Immunother 2010 Mar;59(3):473-7. Epub 2009 Nov 12 doi: 10.1007/s00262-009-0789-1. PMID: 19908041
Improved outcome with immunosuppressive monotherapy after renal transplantation in Schimke-immuno-osseous dysplasia.
Lücke T, Kanzelmeyer N, Baradaran-Heravi A, Boerkoel CF, Burg M, Ehrich JH, Pape L
Pediatr Transplant 2009 Jun;13(4):482-9. Epub 2008 Sep 10 doi: 10.1111/j.1399-3046.2008.01013.x. PMID: 18785907
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, Khalil M, Wu MF, Huls MH, Chang CC, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE
Blood 2007 Oct 15;110(8):2838-45. Epub 2007 Jul 3 doi: 10.1182/blood-2007-05-091280. PMID: 17609424Free PMC Article
Diagnosis and treatment of transplant-related lymphoma.
Swinnen LJ
Ann Oncol 2000;11 Suppl 1:45-8. PMID: 10707778

Prognosis

The Epstein-Barr Virus (EBV) in T Cell and NK Cell Lymphomas: Time for a Reassessment.
Gru AA, Haverkos BH, Freud AG, Hastings J, Nowacki NB, Barrionuevo C, Vigil CE, Rochford R, Natkunam Y, Baiocchi RA, Porcu P
Curr Hematol Malig Rep 2015 Dec;10(4):456-67. doi: 10.1007/s11899-015-0292-z. PMID: 26449716Free PMC Article
Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls.
de Sanjosé S, Bosch R, Schouten T, Verkuijlen S, Nieters A, Foretova L, Maynadié M, Cocco PL, Staines A, Becker N, Brennan P, Benavente Y, Boffetta P, Meijer CJ, Middeldorp JM
Int J Cancer 2007 Oct 15;121(8):1806-12. doi: 10.1002/ijc.22857. PMID: 17557295
Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan.
Pickard A, Chen CJ, Diehl SR, Liu MY, Cheng YJ, Hsu WL, Sun B, Hsu MM, Chen IH, Chen JY, Yang CS, Mittl BL, Chou SP, Ruggles DD, Goldstein AM, Hildesheim A
Int J Cancer 2004 Aug 10;111(1):117-23. doi: 10.1002/ijc.20222. PMID: 15185352
Diagnosis and treatment of transplant-related lymphoma.
Swinnen LJ
Ann Oncol 2000;11 Suppl 1:45-8. PMID: 10707778

Clinical prediction guides

Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls.
de Sanjosé S, Bosch R, Schouten T, Verkuijlen S, Nieters A, Foretova L, Maynadié M, Cocco PL, Staines A, Becker N, Brennan P, Benavente Y, Boffetta P, Meijer CJ, Middeldorp JM
Int J Cancer 2007 Oct 15;121(8):1806-12. doi: 10.1002/ijc.22857. PMID: 17557295
Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma.
Butsch Kovacic M, Martin M, Gao X, Fuksenko T, Chen CJ, Cheng YJ, Chen JY, Apple R, Hildesheim A, Carrington M
Cancer Epidemiol Biomarkers Prev 2005 Nov;14(11 Pt 1):2673-7. doi: 10.1158/1055-9965.EPI-05-0229. PMID: 16284396
Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan.
Pickard A, Chen CJ, Diehl SR, Liu MY, Cheng YJ, Hsu WL, Sun B, Hsu MM, Chen IH, Chen JY, Yang CS, Mittl BL, Chou SP, Ruggles DD, Goldstein AM, Hildesheim A
Int J Cancer 2004 Aug 10;111(1):117-23. doi: 10.1002/ijc.20222. PMID: 15185352
Diagnosis and treatment of transplant-related lymphoma.
Swinnen LJ
Ann Oncol 2000;11 Suppl 1:45-8. PMID: 10707778

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